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Do Nutritional and Inflammatory Biomarkers Have Prognostic Significance in the Early Post Operative Period in Head and Neck Cancer?-A Pilot Study


Affiliations
1 Department of Head and Neck Surgery, HCG Hospitals, HCG Towers, Room 110, Tower 4, No. 8, Kalinga Rao Road, Bangalore-560027, India
2 Centre for Academic Research, Otolaryngology Skills and Expertise, HCG Hospitals, HCG Towers, Room 110, Tower 4, No. 8, Kalinga Rao Road, Bangalore-560027, India
3 Head and Neck Surgery, HCG Hospitals, HCG Towers, Room 110, Tower 4, No. 8, Kalinga Rao Road, Bangalore-560027, India
4 Department of Nutrition, Center for Academic Research, HCG Hospitals, HCG Towers, Room 110, Tower 4, No. 8, Kalinga Rao Road, Bangalore-560027
5 Department of Nutrition, Center for Academic Research, HCG Hospitals, HCG Towers, Room 110, Tower 4, No. 8, Kalinga Rao Road, Bangalore-560027, India
     

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This pilot study evaluated prognostic significance of patient/tumor factors and nutritional/inflammatory parameters with respect to the early post operative complications such as Wound Infection (WI) rates and Length of Hospital Stay (LOS) in 26 Head and Neck Cancer (HNC) surgical patients. The prognostic indices were calculated using patient and tumor related variables including age, sex, co-morbidity, tobacco usage, pathological diagnosis, hemoglobin (Hb) and albumin. The WI rate in the present study was found to be 30% and significantly correlated with both tobacco usage (p=0.021) and nutritional indices such as Albumin/Globulin ratio (A/G) (p=0.034) and Nutritional Risk Index (NRI) (p=0.043). LOS (9.32±2.719) was significantly correlated to Albumin levels (p=0.002), A/G ratio (p=0.02) and Prognostic Nutritional Index (PNI) (p=0.006) and NRI (p=0.002). This pilot study suggested that a positive history of tobacco usage and immune nutritional factors may influence early post-operative outcomes in head and neck surgery.

Keywords

Prognostic Significance, Inflammatory Parameters, Wound Infection (WI) Rates, Pathological Diagnosis, Nutritional Risk Index (NRI).
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  • Do Nutritional and Inflammatory Biomarkers Have Prognostic Significance in the Early Post Operative Period in Head and Neck Cancer?-A Pilot Study

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Authors

Nikhila Sham Sunder Bharadwaj
Department of Head and Neck Surgery, HCG Hospitals, HCG Towers, Room 110, Tower 4, No. 8, Kalinga Rao Road, Bangalore-560027, India
Ravi Nayar
Centre for Academic Research, Otolaryngology Skills and Expertise, HCG Hospitals, HCG Towers, Room 110, Tower 4, No. 8, Kalinga Rao Road, Bangalore-560027, India
Vishal Rao
Head and Neck Surgery, HCG Hospitals, HCG Towers, Room 110, Tower 4, No. 8, Kalinga Rao Road, Bangalore-560027, India
Mehnanaz Fathima
Department of Nutrition, Center for Academic Research, HCG Hospitals, HCG Towers, Room 110, Tower 4, No. 8, Kalinga Rao Road, Bangalore-560027
Afrose Parveen
Department of Nutrition, Center for Academic Research, HCG Hospitals, HCG Towers, Room 110, Tower 4, No. 8, Kalinga Rao Road, Bangalore-560027, India

Abstract


This pilot study evaluated prognostic significance of patient/tumor factors and nutritional/inflammatory parameters with respect to the early post operative complications such as Wound Infection (WI) rates and Length of Hospital Stay (LOS) in 26 Head and Neck Cancer (HNC) surgical patients. The prognostic indices were calculated using patient and tumor related variables including age, sex, co-morbidity, tobacco usage, pathological diagnosis, hemoglobin (Hb) and albumin. The WI rate in the present study was found to be 30% and significantly correlated with both tobacco usage (p=0.021) and nutritional indices such as Albumin/Globulin ratio (A/G) (p=0.034) and Nutritional Risk Index (NRI) (p=0.043). LOS (9.32±2.719) was significantly correlated to Albumin levels (p=0.002), A/G ratio (p=0.02) and Prognostic Nutritional Index (PNI) (p=0.006) and NRI (p=0.002). This pilot study suggested that a positive history of tobacco usage and immune nutritional factors may influence early post-operative outcomes in head and neck surgery.

Keywords


Prognostic Significance, Inflammatory Parameters, Wound Infection (WI) Rates, Pathological Diagnosis, Nutritional Risk Index (NRI).

References