Journal of Pharmaceutical Research

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The present investigation is an attempt to isolate various fungal sources producing mycotoxins from air and soil. Mycotoxins produced by various fungal strains are aflatoxin, gliotoxin, Penicillin, Patulin, Terrecyclic acid, Deoxynivalenol, Malformin, Fumonisin and Trichorzin. The antibacterial potential of the mycotoxins was tested against various test organisms and it was found that the aflatoxin is effective against Micrococcus luteus (MTCC No. 1538) and Pseudomonas sp. (MTCC No. 7021), in case of Gliotoxin it was observed that it has a very good antibacterial property against E. coli (MTCC No. 40), penicillin was found equally good for Micrococcus luteus (MTCC No. 1538) E. coli (MTCC No. 40). Antimicrobial activity of Patulin was observed highest against Micrococcus luteus (MTCC No. 1538), Proteus sp. (MTCC No. 426) was found to be more sensitive to Terrecyclic acid, Micrococcus sp. (MTCC No. 7527) was found most sensitive against Deoxynivalenol generating zone of inhibition 32.66 mm in case of crude and 47.66 mm in case of purified extract and Malformin was found highly effective against Proteus sp. (MTCC No. 426). The Fumonisin and Trichorzin were found as a candidate mycotoxin against Bacillus megaterium (MTCC No. 2412), Micrococcus sp. (MTCC No. 7527), Pseudomonas aeruginosa (MTCC No. 424) respectively.

Keywords

Mycotoxins, Zone of Inhibition, Antibacterial Activity.
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