Journal of Pharmaceutical Research

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The objective of the present study was to carryout cardioprotective effect of Phyllanthus reticulatus leaves extract (PRLE) against isoprenaline (ISP) induced myocardial dysfunction in rats. Rats were administered low (100 mg/kg) and high (500 mg/kg) doses of PRLE orally for three weeks, while propranolol (PRO) was given for one week. At the end of treatment, isoprenaline (150 mg/kg, s.c) was administered for two consecutive days. LDH and CK-MB were estimated in serum as well as in heart tissue homogenate (HTH) apart from SOD, Catalase and TBARS determinations in HTH. Both high and low doses of PRLE as well as PRO were found to decrease the LDH and CK-MB activities in serum and increase in HTH. SOD and Catalase activities were also found to rise significantly in all treated groups. The estimation of TBARS demonstrates an inclination in free radical formation in ISO group that was ameliorated by prophylactic treatment of both high and low dose of PRLE and PRO. The best results were found in group subjected to high dose of PRLE. The results of the study revealed efficacies of both high and low doses of PRLE and PRO on isoprenaline induced myocardial damage in rats.

Keywords

Phyllanthus reticulatus, Antioxidants, Cardioprotection, Isoprenaline.
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