Journal of Pharmaceutical Research

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A validated reverse phase high performance liquid chromatographic method (RP-HPLC) has been developed for the estimation of moprolol in the pharmaceutical preparation using RPC18 column. The mobile phase (Acetonitrile:Methanol:Water) was pumped at a flow rate of 1ml/min in the ratio of 15:50:35 and the eluents were monitored at 274nm at 30°C. The intra and interday precision was found to be less than 2% showing high precision of the assay method. The % recovery of the method was more than 99% and RSD did not exceed 2% indicating high degree of accuracy of the proposed HPLC method. The %RSD for the robustness testing was also less than 2%.The proposed HPLC method can be used for the estimation of moprolol in tablet dosage forms.

Keywords

Moprolol, RP-HPLC, Validation, Recovery, Tablet Dosage.
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