Journal of Pharmaceutical Research

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The purpose of this study was to formulate diclofenac sodium into various types of gel formulations, namely isopropyl alcohol gel, micro-emulsion gel, hydrogel and hydroalcoholic gel using different ingredients. The ensuing goal was to evaluate these gels in terms of in vitro drug release.A modified form of Franz cell was used for diffusion studies. Six different formulations of diclofenac sodium were prepared. Duplicate runs were performed to know the difference in their release extent extending upto 6 hours and the reasons of these differences. The order of release of the drug from various gel formulations was as follows: Hydroalcoholic gel > hydrogel > microemulsion gel > isopropyl alcohol gel.

Keywords

Diclofenac Sodium, Membrane Diffusion, Modified Franz Cell, Formulation Dependent Release.
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