The purpose of this research is to know concentration of content of Cadmium and lead in water and fish along the Tello River in Makassar. This research is descriptive research that is to know the content of Cadmium and Lead in the waters of the Tello River arrived at the Paotere Port of Makassar City. The design of this research is explanatory research to get clarity about the condition of cadmium and lead metals in water, fish organisms and sediments. The research was conducted in May to July 2018. Sampling is done by looking at and guessing the range of locations for cadmium and lead metal contamination, namely upstream and river estuary, settlement areas, river estuaries and industrial locations and areas with a lot of household waste. Data that has been collected and processed is then analyzed by descriptive analysis.The results showed that cadmium content in fish at the research site showed cadmium is highest at station 1 which is the location near the rice plant which is 0.0244 mg / kg, the highest cadmium content in water at station 5 which is the location around the Makassar Paotere Port is 0.01915 ppm. The concentration of cadmium in water is dangerous according to the Republic of Indonesia Ministry of Health and WHO of 0.01 ppm. Furthermore, the cadmium content in sediments in the five stations shows a number <0.10 mg / kg which can be indicated that sediment in the study site has not been contaminated with cadmium at dangerous limits. The lead content in fish, water and sediment at the research location is highest at station 5, which is the location around the Port of Paotere. For water quality shows the average value of water pH during the research while other stations are below 7, the value of dissolved oxygen is only station 2 with an average value above 5 ppm while the other stations have oxygen values below 5 ppm. Furthermore, the water temperature is still within the desired range of aquatic organisms
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