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Singh, Kuldip
- Impact on Some Antioxidant Enzymes and Vitamins in Obese Adolescents of North West Indians
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Authors
Kuldip Singh
1,
Sukhjit Kaur
2
Affiliations
1 Department of Biochemistry, Government Medical College, Patiala-147001, Punjab, IN
2 Department of Biochemistry, Government Medical College, Amritsar-143001, Punjab, IN
1 Department of Biochemistry, Government Medical College, Patiala-147001, Punjab, IN
2 Department of Biochemistry, Government Medical College, Amritsar-143001, Punjab, IN
Source
Toxicology International (Formerly Indian Journal of Toxicology), Vol 22, No 2 (2015), Pagination: 97-102Abstract
Obesity is one of the most common health problems in developed and developing nations such as India. In India, prevalence of obesity among adolescents is 6-24 %. In addition, obesity is considered as one of the risk factors for the initiation of many chronic diseases. Oxidative Stress (OS) is a well-established hallmark of diseases such as diabetes mellitus, cancer, and cardiovascular diseases. The aim of the study was to evaluate OS markers in obese subjects with respect to normal healthy subjects. The present case-control study was carried out on 25 male obese adolescent children with body mass index (BMI) ≥25 kg/m2 and on equal number of male normal healthy children with BMI<15 kg/m2 in the age range of 10-19 years. These subjects were recruited from rural and urban areas of Amritsar District, Punjab, India. The levels of malondialdehyde (MDA), antioxidant enzymes/molecules such as superoxide dismutase (SOD), reduced glutathione (GSH), Glutathione Reductase (GR), Glutathione Peroxidase (GPx), antioxidant Vitamin E and Vitamin C, and β-carotene along with total antioxidant activity (TAA) were evaluated. Significant increase in the concentration of MDA by 114.81% was observed in obese adolescents in comparison to normal healthy adolescents while a significant fall was observed in SOD (47.153%), GSH (60.79%), GR (43.39%), GPx (29.92%), TAA (54.08%), Vitamin E (45.45%), Vitamin C (56.14%), and β-carotene (32.88%) levels in obese adolescents as compared to normal healthy control adolescents. Aforementioned observations suggested that OS induced in the obese adolescents even in the absence of any chronic diseases. Therefore, obesity should be treated at the early stages to prevent further complications.Keywords
Antioxidants, Cardiovascular Disease, Malondialdehyde, Obesity, Oxidative Stress, Reduced Glutathione Superoxide Dismutase, Vitamin E, Vitamin C.
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