Toxicology International (Formerly Indian Journal of Toxicology)

Pronobesh Chattopadhyay , Aadesh Upadhyay , Amit Agnihotri , Sanjeev Karmakar , Danswerang Ghoyary , Vijay Veer

Abstract

Mycotoxins are fungal toxin and contaminated to human through food‑stuffs. Hematological abnormality, mainly thrombocytopenia and leukopenia are induced after consumption of mycotoxin. Experiments were conducted to evaluate the hematotoxicity of trichothecenes mycotoxins in Sprague‑Dawley rats. Hematological parameters viz. Hemoglobin, hematocrit, erythrocyte count (RBC), white blood cell count (WBC), lymphocytes, monocytes, neutrophils, eosinophils, basophils, mean corpuscular volume, mean corpuscular hemoglobin, mean corpuscular hemoglobin concentration, red blood cell distribution width, mean platelet volume, plateletcrit and platelet distribution width were determined at 0, 6, 12 and 24 h after injection of 0.5 ml of T‑2, Deoxynivalenol (DON), nivalenol, zearalenone, neosolaniol, ochratoxin‑B mycotoxin equivalent to 1 × 10−3 μg/μl to Sprague‑Dawley rats. Experiments showed that trichothecenes toxin produces severe hematological alternation. The reductions of RBC and WBC were observed in all Fusarium mycotoxins treated group. T‑2 toxin group shows severe toxicity as compared to other mycotoxin treated group. DON is the least hematotoxicity and T‑2 the most.

Keywords

Hematotoxicity, mycotoxins, Sprague-Dawley rats

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