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Evaluation of N – Butanol Fraction of Albizia Procera (Roxb.) Benth Against Diabetes Mellitus with Rats


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1 Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai 3., India
     

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The antidiabetic activity of n–butanol fraction of Albizia Procera was evaluated in Streptozotocin induced diabetic rats. The n–butanol fraction of Albizia Procera (200 and 400 mg/kg) were administered to Streptozotocin induced diabetic rats for 14 days and blood glucose levels (BGLs) of the diabetic rats were monitored at intervals of hours and days throughout the duration of the treatment. The n-butanol fraction of Albizia procera was found to be non-toxic up to the dose of 2000mg/kg and did not cause any death of the tested animals. STZ induced rats significantly increase the blood glucose level as compared to other groups. N- butanol fraction produces dose dependent effect as the high dose (400mg/kg) shows more significant antidiabetic action compared to 200mg/kg (P< 0.01).These results suggest that the N – Butanol fraction of Albizia Procera possess antidiabetic effect on Streptozotocin -induced diabetic rats and this justifies its use in ethno medicine and can be exploited in the management of diabetes.

Keywords

Antidiabetic, Albizia Procera, Streptozotocin, n – butanol, Blood glucose.
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  • Stefanis L, Burke RE, Greene LA. Apoptosis in neurodegenerative disorders. Curr Opin Neurol. 1997;10:299–305

  • ICFRE: Albizia procera (Safed Siris). Extension Series. Dehra Dun, India: Indian Council of Forestry Research and Education (ICFRE) 1995; 12.

  • Parotta JA and Roshetko JM: Albizia procera - white siris for reforestation and agroforestry. Winrock International press, Arkansas, USA 1997.

  • OECD Guidelines for the Testing of Chemicals (2001). OECD 423. Acute Oral Toxicity—Acute Toxic Class Method. Organisation for Economic Cooperation and Development, Paris

  • Asmita Samadder, Anisur Rahman and Khuda-Bukhsh. Nanotechnological approaches in diabetes treatment, A new horizon, World J Transl Med, 2014; 3(2): 84-95.

  • Augustyns P. Van der Veken, K, Haemers A. The Therapeutic Potential of Inhibitors of Dipeptidyl Peptidase IV (DPP IV) and Related Proline Specific Dipeptidyl Aminopeptidases, Current Medicinal Chemistry, 2015; 12: 971-998.

  • Aurelio O, Hector H, Guadalupe M, Leticia, Q, Sylvain, B. Asymmetric synthesis of 3-methylthio alcohols by intramolecular Michael addition reactions. Tetrahedron letters, 2005; 46(13):2243-2246.

  • Monago Comfort C., Nwodo O. Fred C.Antidiabetic Effects of Crude Flavanoid and Alkaloid of Abrus precatorius Linn Seed in Alloxan Diabetic Rabbits. Research Journal of Pharmacognosy and Phytochemistry. 2010; 2(4): 331-335.

  • Ena Gupta, Abubakar Mohammed, Shalini Purwar, Syed Ibrahim Rizvi, Shanthy Sundaram Diminution of oxidative stress in alloxan-induced diabetic rats by Stevia rebaudiana. Res. J. Pharmacognosy and Phytochem. 2017; 9(3): 158-166.

  • D. Jeeva Anandhi, G. Sriram Prasath, S. Subramanian Evaluation of Antidiabetic Potential of Hibiscus rosasinensis leaves extract in alloxan- induced diabetic rats. Research J. Pharmacognosy and Phytochemistry 2013; 5(6): 306-314

  • Baranowski, M, Agnieszka, BZ, Piotr, Z. Pioglitazone induces lipid accumulation in the rat heart despite concomitant reduction in plasma free fatty acid availability. Arch Biochem Biophy,2008; 477(1):86-91.

  • Blumenthal. MD, Hyoju C Russell. T, Gregory LB. The impact of obesity on cardiovascular disease risk factors and subclinical vascular disease. Arch intern Med, 2008; 168(9):928-935.

  • Preeti Tiwari. Evaluation of Antihyperlipidemic Potential of Amritarishta Prepared by Traditional and Modern Methods in Hyperlipidemic Rats. Research J. Pharmacognosy and Phytochemistry 2013; 5(6): 315-319.

  • Kavitha S, Ravi D, Vijayabharathi V, Parthasarathy R, Rajeshwari S. Blood Glucose Lowering Potential of Chinese Violet (Asystasia gangetica (L.) T. Anderson) in Normal and Streptozotocin Induced Diabetic Rats. Res. J. Pharmacognosy and Phytochem. 2014; 6(4):170-175.

  • P. M. Udia, O. J. Ogbonna, A. B. Antai, I. F. Mbatutung, S. E. Eyo. Oral Glucose Tolerance Test and Some Haematological Effects of Aqueous Leaf Extract of Rothmannia hispida (K. Schunn) Fargel on Normoglycaemic albino rats. Research J. Pharmacognosy and Phytochemistry 2013; 5(6): 300-305.

  • S. Mohan Raj, Shahid Mohammed, Vinoth Kumar S, Santhosh Kumar C, Subal Debnath. Antidiabetic Effect of Luffa acutangula Fruits and Histology of Organs in Streptozotocin Induced Diabetic in Rats. Research J. Pharmacognosy and Phytochemistry 2012; 4(2): 64-69.

  • Benito Johnson, Roja rani. A, P. Ajay Kumar, Nehru Sai Suresh Chalichem, Ashokkumar Javvadi. Antidiabetic Potential of Erythrina indica in STZ Induced Rats. Research J. Pharmacognosy and Phytochemistry 2012; 4(2): 70-74.

  • Dongare SS, Maske AP, Patil SM, Umbare RP, Mate GS. Antidiabetic Activity of Marsilea quadrifolia linn in Alloxan-Diabetic Rats. Research J. Pharmacognosy and Phytochemistry 2009; 1(1):15-17.

  • Borges ML, Espinoza C Daly, and Beckers, A. Gross total resection or debulking of pituitary adenomas improves hormonal control of acromegaly by somatostatin analogs. Eur J Endocrinol, 2005;152:61-66.

  • Borghi Thomas, Rosei, Enrico Agabiti, Claudio Bardin, Dawson, Jessef Dominiczak, Anna Kielstein, Jan T Manolis, Athanasios J, Perez-Ruiz Fernando Mancia, Giuseppe. Serum uric acid and the risk of cardiovascular and renal disease journal of hypertension, 2015; 33(9):1729- 1741.

  • Brahm Kumar Tiwari, Kanti Bhooshan Pandey, B. Abidi, and Syed Ibrahim Rizvi Markers of Oxidative Stress during Diabetes Mellitus, Journal of Biomarkers, 2013; 8 -16.

  • Brian Irons. New Pharmacotherapies for Type 2 Diabetes, Cardiology/Endocrinology 2013; 3 (1): 1-25.


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  • Evaluation of N – Butanol Fraction of Albizia Procera (Roxb.) Benth Against Diabetes Mellitus with Rats

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Authors

D. Anand
Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai 3., India
M. Sathish
Department of Pharmaceutical Chemistry, College of Pharmacy, Madras Medical College, Chennai 3., India

Abstract


The antidiabetic activity of n–butanol fraction of Albizia Procera was evaluated in Streptozotocin induced diabetic rats. The n–butanol fraction of Albizia Procera (200 and 400 mg/kg) were administered to Streptozotocin induced diabetic rats for 14 days and blood glucose levels (BGLs) of the diabetic rats were monitored at intervals of hours and days throughout the duration of the treatment. The n-butanol fraction of Albizia procera was found to be non-toxic up to the dose of 2000mg/kg and did not cause any death of the tested animals. STZ induced rats significantly increase the blood glucose level as compared to other groups. N- butanol fraction produces dose dependent effect as the high dose (400mg/kg) shows more significant antidiabetic action compared to 200mg/kg (P< 0.01).These results suggest that the N – Butanol fraction of Albizia Procera possess antidiabetic effect on Streptozotocin -induced diabetic rats and this justifies its use in ethno medicine and can be exploited in the management of diabetes.

Keywords


Antidiabetic, Albizia Procera, Streptozotocin, n – butanol, Blood glucose.

References