Research Journal of Pharmacy and Technology

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Drug Release and Mucoadhesive behavior of Hydrogel in Chemo-Radiotherapy induced Oral Mucositis


Affiliations
1 Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jaipur-302017, India
2 Vedica College of Pharmacy, Bhopal 462033, India
     

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In vitro drug release investigations are obligatory tool in the drug product development. Mucoadhesion time and viscosity are vitals in adherence with comprehensive period of time. Oral mucositis is a frequent and potentially severe obstacles caused by chemo-radiotherapy. L-Glutamine reported to reduce the length and severity of chemo-radiotherapy induced oral mucositis. Hydrogel is biocompatible, resilient, and mucoadhesive in local delivery of active ingredient in buccal cavity. The aim of the present study was to evaluate in vitro drug release, mucoadhesion of L-Glutamine hydrogels. Hydrogels of L-Glutamine containing natural and synthetic bioadhesive polymers (w/w %): Carbopol 934P (0.25-1), Guar gum (0.05-1), Gum acacia (0.15-1) and Sodium Alginate (0.1-1) were prepared along with other adjutants. These hydrogel were evaluated for different physicochemical attributes (pH, viscosity, drug release, mucoadhesion). The prepared hydrogel were homogenous and opaque with suitable pH (6 –7). The formulation containing 0.5% Carbopol 934P (CG2) showed the highest release rate (>85%), order of release rate was Guar gum > Gum acacia > Sodium alginate. Mucoadhesion (>6 hours, CG3<CG2<CA4), shown against copious salivary flow, due to viscosity and bioadhesion bond with mucin and interpenetration of polymer. Types and concentrations of polymers used somewhat affected and considerably diverge in formulation design and their physicochemical, release distinctiveness and adhesiveness. The prepared hydrogel may well bearable, supple, with optimum drug release, and justifiable mucoadhesion in oral mucositis induced by chemotherapy radiotherapy. The present study is limited but other aspects of different formulations should be investigated further.

Keywords

Buccal Drug Delivery, Chemo-Radiotherapy, Oral Mucositis, Hydrogel, L-Glutamine, Mucoadhesion.
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  • Drug Release and Mucoadhesive behavior of Hydrogel in Chemo-Radiotherapy induced Oral Mucositis

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Authors

Praveen Kumar Jain
Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jaipur-302017, India
Ritu Gilhotra
Gyan Vihar School of Pharmacy, Suresh Gyan Vihar University, Jaipur-302017, India
Mohan Lal Kori
Vedica College of Pharmacy, Bhopal 462033, India

Abstract


In vitro drug release investigations are obligatory tool in the drug product development. Mucoadhesion time and viscosity are vitals in adherence with comprehensive period of time. Oral mucositis is a frequent and potentially severe obstacles caused by chemo-radiotherapy. L-Glutamine reported to reduce the length and severity of chemo-radiotherapy induced oral mucositis. Hydrogel is biocompatible, resilient, and mucoadhesive in local delivery of active ingredient in buccal cavity. The aim of the present study was to evaluate in vitro drug release, mucoadhesion of L-Glutamine hydrogels. Hydrogels of L-Glutamine containing natural and synthetic bioadhesive polymers (w/w %): Carbopol 934P (0.25-1), Guar gum (0.05-1), Gum acacia (0.15-1) and Sodium Alginate (0.1-1) were prepared along with other adjutants. These hydrogel were evaluated for different physicochemical attributes (pH, viscosity, drug release, mucoadhesion). The prepared hydrogel were homogenous and opaque with suitable pH (6 –7). The formulation containing 0.5% Carbopol 934P (CG2) showed the highest release rate (>85%), order of release rate was Guar gum > Gum acacia > Sodium alginate. Mucoadhesion (>6 hours, CG3<CG2<CA4), shown against copious salivary flow, due to viscosity and bioadhesion bond with mucin and interpenetration of polymer. Types and concentrations of polymers used somewhat affected and considerably diverge in formulation design and their physicochemical, release distinctiveness and adhesiveness. The prepared hydrogel may well bearable, supple, with optimum drug release, and justifiable mucoadhesion in oral mucositis induced by chemotherapy radiotherapy. The present study is limited but other aspects of different formulations should be investigated further.

Keywords


Buccal Drug Delivery, Chemo-Radiotherapy, Oral Mucositis, Hydrogel, L-Glutamine, Mucoadhesion.

References