Research Journal of Pharmacy and Technology

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Formulation and Evaluation of Maltodextrin Based Doxorubicin HCl Proniosomes


Affiliations
1 JNTU Hyderabad and V. L. College of Pharmacy, Raichur, India
2 Department of Pharmaceutics, V. L. College of Pharmacy, Raichur, India
3 Department of Pharmaceutics, Oxford College of Pharmacy, Bengaluru, India
     

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Aim of the present research work is to prepare and evaluate maltodextrin based proniosomes loaded with doxorubicin HCl. Proniosomes were prepared by slurry method using molar ratios of nonionic surfactant with cholesterol and keeping drug, maltodextrin and DCP constant. The niosomes were prepared by simple hydration and further evaluated for entrapment efficiency, particle size and shape analysis by optical microscopy, in vitro drug release study, kinetic data analysis and model fitting. Stability study by ICH guides lines. The study revels more stable when stored at 4°C. The formulation FD3, which showed entrapment efficiency of 84.88 ± 0.14 and in vitro release over the period of 36h 95.19± 0.20, was found to be best formulation is span 60. The niosomes shows the Korsemayer Peppas exponential n<0.84 indicate the release mechanism was non Ficknian (anomalous transport) i.e. drug released by erosion followed by diffusion mechanism.

Keywords

Doxorubicin HCl, Proniosomes, Niosomes, Surfactants, Cholesterol.
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  • Formulation and Evaluation of Maltodextrin Based Doxorubicin HCl Proniosomes

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Authors

Srikanth
JNTU Hyderabad and V. L. College of Pharmacy, Raichur, India
Y. Anand Kumar
Department of Pharmaceutics, V. L. College of Pharmacy, Raichur, India
C. Mallikarjuna Setty
Department of Pharmaceutics, Oxford College of Pharmacy, Bengaluru, India

Abstract


Aim of the present research work is to prepare and evaluate maltodextrin based proniosomes loaded with doxorubicin HCl. Proniosomes were prepared by slurry method using molar ratios of nonionic surfactant with cholesterol and keeping drug, maltodextrin and DCP constant. The niosomes were prepared by simple hydration and further evaluated for entrapment efficiency, particle size and shape analysis by optical microscopy, in vitro drug release study, kinetic data analysis and model fitting. Stability study by ICH guides lines. The study revels more stable when stored at 4°C. The formulation FD3, which showed entrapment efficiency of 84.88 ± 0.14 and in vitro release over the period of 36h 95.19± 0.20, was found to be best formulation is span 60. The niosomes shows the Korsemayer Peppas exponential n<0.84 indicate the release mechanism was non Ficknian (anomalous transport) i.e. drug released by erosion followed by diffusion mechanism.

Keywords


Doxorubicin HCl, Proniosomes, Niosomes, Surfactants, Cholesterol.

References