Research Journal of Pharmacy and Technology

Open Access Open Access  Restricted Access Subscription Access
Open Access Open Access Open Access  Restricted Access Restricted Access Subscription Access

A Review on Significance of Ocimum tenuiflorum and Alpinia galanga and their Combined Effects


Affiliations
1 Department of Bio-Engineering, B. Tech Biotechnology, Vels Institute of Science, Technology and Advanced Studies, Chennai, India
     

   Subscribe/Renew Journal


The plants are one of the common and highly useful medicinal sources that are used since ages. Every single parts of plant like leaves, stem, ischolar_mains, seeds, fruits and flowers has its very own restorative medicinal properties and applications. They are the rich sources of natural phytoconstitutents and have more therapeutic potentials which are used for drug development. Medicinal plants are essential wellspring of organic compounds. The Aromatic plant Ocimum tenuiflorum commonly called as Tulsi and Alpinia galanga commonly as greater Galangal are two of the natural plants that are loaded with more medicinal properties like antimicrobial, anticancer, anti-inflammatory, etc. Tulsi is known as ‘Queen of Herbs’ and its eugenol a phenolic phytoconstituent which is responsible for therapeutic actions against skin infections, diabetes, neuralgia, cancer, respiratory, gastric, cardiac and genitourinary disorders, digestion issues and so on. Galangal mainly the rhizome part is famous for food spices and its fragrance. It has more potency to fight against different kinds of cancer; it is a good anti-inflammatory agent and antimicrobial agent and a perfect free radical scavenger. The both ayurvedic plant species have a predominant solution to modern lifestyle health related issues. Their activities get more enhanced when their extract are combined as both the benefits act for a single cause. This paper summaries the pharmacological activity of both Ocimum tenuiflorum and Alpinia galanga and their combined effects.

Keywords

Medicinal Plants, Ocimum tenuiflorum, Alpinia galanga, Phytoconstituents, Combined Effects.
Subscription Login to verify subscription
User
Notifications
Font Size


  • Abdullah F, Subramanian P, Ibrahim H, Malek A, Nurestri S, Lee GS, Hong SL. Chemical composition, antifeedant, repellent, and toxicity activities of the rhizomes of galangal, Alpinia galanga against Asian subterranean termites, Coptotermesgestroi and Coptotermescurvignathus (Isoptera: Rhinotermitidae). Journal of Insect Science. 2015 Jan 1;15(1).

  • Al‐Yahya MA, Rafatullah S, Mossa JS, Ageel AM, Al‐Said MS, Tariq M. Gastric antisecretory, antiulcer and cytoprotective properties of ethanolic extract of Alpinia galangal Willd in rats. Phytotherapy Research. 1990 Jun;4(3):112-4.

  • Angell M, Kassirer JP. Alternative medicine-The risks of untested and unregular remedies. N Engl J Med. 1998;339(12):839-41.

  • Aruna K, Sivaramakrishnan VM. Anti-carcinogenic effects of some Indian plantproducts. Food Chem Toxicol 1992; 30: 953–956.

  • Banerjee S, Prashar R, Kumar A, Rao AR. Modulatory influence of alcoholic extract of Ocimum leaves on carcinogen‐metabolizing enzyme activities and reduced glutathione levels in mouse.

  • Bhat KKP. Medicinal plant information databases. In: Non-Wood Forest Products. Medicinal Plants for Conservation and Health Care, Rome: Food and Agriculture Organization; 1995.

  • Chellaih P, Sivadas G, Chintu S, Vedam VV, Arunachalam R, Sarsu M. Effect of anti-asthmatic drugs on dental health: a comparative study. Journal of pharmacy and bioallied sciences. 2016 Oct;8(Suppl 1): S77.

  • Chouni A, Paul S. A Review on Phytochemical and Pharmacological Potential of Alpinia galanga. Pharmacognosy Journal. 2018;10(1)

  • Chuah CH. Comparative study of volatile compounds from genus Ocimum. American Journal of Applied Sciences. 2009;6(3):523.

  • Cohen MM. Tulsi-Ocimum sanctum: A herb for all reasons. Journal of Ayurveda and integrative medicine. 2014 Oct;5(4):251.

  • Deepa J, Aleykutty NA, Jyoti H. Comparative Evaluation of InvitroAnti-inflammatory Activity of Psidium Guajava And Syzygium Cumini Leaves. International Journal of Ayurveda and Pharma Research. 2017 Nov 8;5(10).

  • Deo B, Nath M, Nayak PK, Dhal Y. Evaluation of antioxidant activity of Ocimum tenuiflorum, an important medicinal herb. Int J Pl An and Env Sci. 2013;3(2):150-4.

  • Elsamma T, Shanmugam J, Rafi MM. Antibacterial activity of plant belonging to Zingiberaceae family (Alpinia galanga). Biomedicine. 1996;16(2/3):15-20.

  • Ghotkar MN, Kharade SS, Chavan RS, Jadhav RS, Jagtap NM, Vambhurkar GB. Formulation and Evaluation of Herbal Facewash for Acne. Asian Journal of Pharmaceutical Analysis. 2018 Dec 1;8(4):183-5.

  • H. Haraguchi, Y. Kuwata, K. Inada, K. Shingu, K. Miyahara, M. Nagao, A. Yagi, Planta Medica, 1996, 62 (4), 308-313.

  • http://www.yourarticlelibrary.com/biology/plants/tulsi-sources-macroscopicalcharacters-and-uses/49961.

  • Jamshidi N, Cohen MM. The clinical efficacy and safety of Tulsi in humans: a systematic review of the literature. Evidence-Based Complementary and Alternative Medicine. 2017;2017.

  • Jayati BA, Kumar A, Goel A, Gupta S, Rahal A. In vitro antiviral potential of Ocimum sanctum leaves extract against Newcastle disease virus of poultry. Int J MicrobiolImmunol Res. 2013;2(7):51

  • Jeba WC. A Comparative Study on Phytochemical Antimicrobial and Immunomodulatory Activity of Ocimum Species.)

  • Juntachote T, Berghofer E. Antioxidative properties and stability of ethanolic extracts of Holy basil and Galangal. Food Chemistry. 2005 Sep 1;92(2):193-202.

  • Kaushik D, Yadav J, Kaushik P, Sacher D, Rani R. Current pharmacological and phytochemical studies of the plant Alpinia galanga. Zhong Xi Yi Jie He XueBao. 2011 Oct;9(10):1061-5

  • Kaushik D et al, Current pharmacological and phytochemical studies of the plant Alpinia galanga. Zhong Xi Yi JieHeXueBao. 2011 Oct;9(10):1061-5.

  • Kayastha BL. Queen of herbs tulsi (Ocimum sanctum) removes impurities from water and plays disinfectant role. J Med Plants Stud. 2014;2(2).

  • Kelm MA, Nair MG. Mosquitocidal compounds and a triglyceride, 1, 3-dilinoleneoyl-2-palmitin, from Ocimum sanctum. Journal of agricultural and food chemistry. 1998 Aug 17;46(8):3092-4.

  • Konno K, Sawamura R, Sun Y, Yasukawa K, Shimizu T, Watanabe W, Kato M, Yamamoto R, Kurokawa M. Antiviral activities of diarylheptanoids isolated from Alpiniaofficinarum against respiratory syncytial virus, poliovirus, measles virus, and herpes simplex virus type 1 in vitro. Natural product communications. 2011 Dec;6(12):1881-4.

  • Kumar M, Chayadevi A, Poornachandra Rao K, Nateshan A. Studies on The De Fluoridation Efficacy of Chrysopogon Zizaniodides, Ocimum tenuiflorum And Their Combinational Use.

  • Lee YS, Kang OH, Choi JG, Oh YC, Chae HS, Kim JH, Park H, Sohn DH, Wang ZT, Kwon DY. Synergistic effects of the combination of galangin with gentamicin against methicillin-resistant Staphylococcus aureus. The Journal of Microbiology. 2008 Jun 1;46(3):283-8.)

  • Madan NV, Sahu MS, Jambhulkar YT, Mamidwar AS, Hingawe NT, Maliye AN. A Review on Euphorbiaceae plants for peptic ulcer. Research Journal of Pharmacognosy and Phytochemistry. 2018;10(4):336-9.

  • Manikandan P, Vidjaya Letchoumy P, Prathiba D, Nagini S. Combinatorial chemopreventive effect of Azadirachtaindica and Ocimum sanctum on oxidantantioxidant status, cell proliferation, apoptosis and angiogenesis in a rat forestomach carcinogenesis model. Singapore medical journal. 2008 Oct 1;49(10):814.)

  • Mirje MM, Zaman SU, Ramabhimaiah S. Evaluation of the anti-inflammatory activity of Ocimum sanctum Linn (Tulsi) in albino rats. Int. J. Curr. Microbiol. App. Sci. 2014;3(1):198-205.

  • Mondal S, Mirdha BR, Mahapatra SC. The science behind sacredness of Tulsi (Ocimum sanctum Linn.). Indian J Physiol Pharmacol. 2009 Oct;53(4):291-306.

  • Nagarajun S, Jain HC, Aulakh GS. Indigenous plants used in fertility control. Cultivation and utilization of medicinal plants. Editors: Atal CK and Kapoor BM (Published by PID CSIR). 1989;558.)]

  • Nayakal O, Patil P, Bhutkar M, Randive D, Bhinge S. Formulation and Evaluation of Fast Dissolving Tablets containing Clopidogrel bisulfate using holy basil seeds as a natural superdisintegrant. Research Journal of Pharmaceutical Dosage Forms and Technology. 2018 Oct 30;10(4):209-14.

  • Parasuraman S, Balamurugan S, Christapher PV, Petchi RR, Yeng WY, Sujithra J, Vijaya C. Evaluation of antidiabetic and antihyperlipidemic effects of hydroalcoholic extract of leaves of Ocimum tenuiflorum (Lamiaceae) and Prediction of Biological Activity of its Phytoconstituents. Pharmacognosy research. 2015 Apr;7(2):156

  • Patil NS, Patil KB, Patil MR, Ahirrao RA. Antimitotic Activity of Fruits of Momordicadioica by using Allium cepa Root Tip Assay. Asian Journal of Pharmaceutical Research. 2018;8(4):221-4.

  • Pattanayak P, Behera P, Das D, Panda SK. Ocimum sanctum Linn. A reservoir plant for therapeutic applications: An overview. Pharmacognosy reviews. 2010Jan;4(7):95.

  • Prakash P, Gupta N. Therapeutic uses of Ocimum sanctum Linn (Tulsi) with a note on eugenol and its pharmacological actions: a short review. Indian journal of physiology and pharmacology. 2005 Apr;49(2):125.

  • QI SF, YAO QQ. Review on the chemical constituents and pharmacological activities of Alpinia L.[J]. Qilu Pharmaceutical Affairs. 2009; 5:024.

  • Rios JL, Recio MC. Medicinal plants and antimicrobial activity. Journal of ethnopharmacology. 2005 Aug 22;100(1-2):80-4.

  • Roy SK, Pahwa S, Nandanwar H, Jachak SM. Phenylpropanoids of Alpinia galanga as efflux pump inhibitors in Mycobacterium smegmatis mc2 155. Fitoterapia. 2012;83(7):1248-55. doi:https://doi.org/10.1016/j.fitote.2012.06.008.

  • Sagar K, Aneesha S, Uppin P. Phytochemical Studies and Quantification of total content of Phenols, Tannins and Flavonoids in selected endangered plant species. Research Journal of Pharmacognosy and Phytochemistry. 2018;10(4):277-81.

  • Sahu M, Rao SP. In-vitro Inhibitory Activity of Medicinal Plant (Syzygiumcumini Seed) against Carbohydrate Metabolizing Enzymes. Research Journal of Pharmacognosy and Phytochemistry. 2018;10(4):311-9.

  • Samarghandian S, Afshari JT, Hosseini M. Antiproliferative activity and induction of apoptotic by ethanolic extract of Alpinia galangarhizhome in human breast carcinoma cell line. BMC complementary and alternative medicine. 2014 Dec;14(1):192.

  • Samson J, Sheeladevi R, Ravindran R. Oxidative stress in brain and antioxidant activity of Ocimum sanctum in noise exposure. Neurotoxicology. 2007 May 1;28(3):679-85.

  • Sathish R, Nachammai V, Pasupathi G, Senthilkumar M. In-Vitro Antiulcer and Antioxidant Activity of Ethanolic Extract of Ficusracemosa L. latex. Research Journal of Pharmacology and Pharmacodynamics. 2018;10(4):159-62.

  • Sawant R, Baghkar A, Jagtap S, Harad L, Chavan A, Khan NA, Yevale RP, Kale MK. A Review on-Herbs in Anticancer. Asian Journal of Research in Pharmaceutical Science. 2018;8(4):179-84.

  • Sethi J, Yadav M, Sood S, Dahiya K, Singh V. Effect of tulsi (Ocimum Sanctum Linn.) on sperm count and reproductive hormones in male albino rabbits. International journal of Ayurveda research. 2010 Oct;1(4):208.

  • Singh S, Majumdar DK. Analgesic activity of Ocimum sanctum and its possible mechanism of action. International journal of Pharmacognosy. 1995 Jan 1;33(3):188-92.

  • Smet PA. Should herbal medicine-like products be licensed as medicines? BMJ. 1995;310(6986):1023-4.

  • Srivastava B, Singh P, Shukla R, Dubey NK. A novel combination of the essential oils of Cinnamomum camphora and Alpinia galanga in checking aflatoxin B1 production by a toxigenic strain of Aspergillusflavus. World Journal of Microbiology and Biotechnology. 2008 May 1;24(5):693-7.

  • Srividya AR, Dhanabal SP, Satish Kumar MN, Parth Kumar HB. Antioxidan Srividya AR, Dhanabal SP, Satish Kumar MN, Parth Kumar HB. Antioxidant and antidiabetic activity of Alpinia galanga. International journal of Pharmacognosy and phytochemical research. 2010;3(1):6-12.

  • Sukhirun N, Pluempanupat W and Bullangpoti V. Impact of Alpinia galanga rhizome extract on Bactrocera dorsalis population. Communications in Agricultural and Applied Biological Sciences. (2010); 75:399-403.

  • The Effect of Mixture of Alpinia galanga, Eurycoma Longifolia Jack and Syzygium Aromaticum Crude Extract on the Growth of Saccharomyces Cerevisiae and Escherichia Coli Nur Jasrina Jaafar1, Kaswandi Md. Ambia1, HingHiang Lian2 and Rahim Md. Noah1.

  • Tripathi S, Saroj BK, Khan MY. Pharmacological Evaluation of Folk Medicinally used Plant by usin Streptozotocin Induced Rat Models. Asian Journal of Pharmacy and Technology. 2018;8(4):231-43.

  • Verma S. Chemical constituents and pharmacological action of Ocimum sanctum (Indian holy basil-Tulsi). J. Phytopharmacol. 2016;5(5):205-7

  • Viswanathan MB, Ananthi JJ, Venkateshan N. Pharmacognostical Studies on the leaves of Jatropha tanjorensis. Research Journal of Pharmacognosy and Phytochemistry. 2018;10(4):291-8.

  • W. Pompimon, J. Jomduang, U. Prawat, S. Mankhetkorn, American Journal of Agricultural and Biological Sciences, 2009, 4 (1), 83-91

  • Wu Y, et al. Composition of the essential oil from Alpinia galanga rhizomes and its bioactivity on Lasiodermaserricorne. Bulletin of Insectology. (2014); 67:247-254.

  • Yamani HA, Pang EC, Mantri N, Deighton MA. Antimicrobial activity of Tulsi (Ocimum tenuiflorum) essential oil and their major constituents against three species of bacteria.Frontiers in microbiology. 2016 May 17; 7:681.

  • Yashoda K, Vivek MM, Prashith KT, Raghavendra HL. Antimicrobial and radical scavenging activity of leaf and rhizome extract of Alpinia galanga (L.) Wild (Zingiberaceae). Int. J. Drug Dev. Res. 2014;6(1):239-47.


Abstract Views: 174

PDF Views: 0




  • A Review on Significance of Ocimum tenuiflorum and Alpinia galanga and their Combined Effects

Abstract Views: 174  |  PDF Views: 0

Authors

P. Brindha Devi
Department of Bio-Engineering, B. Tech Biotechnology, Vels Institute of Science, Technology and Advanced Studies, Chennai, India
K. R. Bagyalakshmi
Department of Bio-Engineering, B. Tech Biotechnology, Vels Institute of Science, Technology and Advanced Studies, Chennai, India
S. Gayathri
Department of Bio-Engineering, B. Tech Biotechnology, Vels Institute of Science, Technology and Advanced Studies, Chennai, India

Abstract


The plants are one of the common and highly useful medicinal sources that are used since ages. Every single parts of plant like leaves, stem, ischolar_mains, seeds, fruits and flowers has its very own restorative medicinal properties and applications. They are the rich sources of natural phytoconstitutents and have more therapeutic potentials which are used for drug development. Medicinal plants are essential wellspring of organic compounds. The Aromatic plant Ocimum tenuiflorum commonly called as Tulsi and Alpinia galanga commonly as greater Galangal are two of the natural plants that are loaded with more medicinal properties like antimicrobial, anticancer, anti-inflammatory, etc. Tulsi is known as ‘Queen of Herbs’ and its eugenol a phenolic phytoconstituent which is responsible for therapeutic actions against skin infections, diabetes, neuralgia, cancer, respiratory, gastric, cardiac and genitourinary disorders, digestion issues and so on. Galangal mainly the rhizome part is famous for food spices and its fragrance. It has more potency to fight against different kinds of cancer; it is a good anti-inflammatory agent and antimicrobial agent and a perfect free radical scavenger. The both ayurvedic plant species have a predominant solution to modern lifestyle health related issues. Their activities get more enhanced when their extract are combined as both the benefits act for a single cause. This paper summaries the pharmacological activity of both Ocimum tenuiflorum and Alpinia galanga and their combined effects.

Keywords


Medicinal Plants, Ocimum tenuiflorum, Alpinia galanga, Phytoconstituents, Combined Effects.

References