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Study of Growth Hormone Response to Clonidine Stimulation in Short Stature with Growth Hormone Deficiency (GHD)


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1 Baqubaa-Technical institute Middle Technical University (MTU), Iraq
     

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Background and Objective: Short stature is a condition when a person height is less two or more (standard deviations) (SD) than average height for persons of the same gender and chronologic age. There are different causations of "short stature" which extent from familial (genetic), "endocrine disorders, and chronic illnesses to idiopathic. Detecting and tending of curative disorders such anemia, nourished, disturbance of endocrine glands like hypothyroidism and shortage of growth hormone can cause attainability of predicted height. This study aimed to detect reasons of "short stature" in children and teenagers and to estimate the clonidine effectiveness on growth hormone level. Patients and Methods: In this study, 50 children and adolescent (1-18 years old) with symptoms of short stature where attended Al-Batool Teaching Obstetric Hospital at the period from March to September 2016, heights of all patients were estimated, growth hormone levels were evaluated before and after clonidine therapy using ELISA technique. Results: this study showed that all patients had height lower than normal (2 standard deviation below the mean). Growth hormone deficiency) was the main cause of "short stature" (44, 88 %) and there was significant differences in growth hormone level before and after clonidine intake (p ˂ 0.00). Conclusions: (Growth hormone deficiency) was the major cause of "short stature". Clonidine was effective therapy in stimulation and support the level of growth hormone.

Keywords

Short Stature, Growth Hormone, Clonidine.
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  • Hogler W and Shaw N. Childhood Growth Hormone Deficiency, Bone Density, Structures and Fractures: Scrutinizing the Evidence. Clin. Endocrinol. 2010; 72, 281-289

  • Lam WF, Hau WL and Lam TS. Evaluation of referrals for genetic investigation of short stature in Hong Kong. Chinese Med J. 2002, 115(4):607–611.

  • Soliman AT and Sanctis VD. An approach to constitutional delay of growth and puberty. Indian J Endocrinol Metabol. 2012, 16(5): 698–705.

  • Ranke MB, Grauer ML, Kistner K, Blum WF and Wollmann HA. Spontaneous adult height in idiopathic short stature. Hormone Res. 1995, 44(4):152–157.

  • Alatzoglou KS, Webb EA, Le Tissier P, and Dattani M T. Isolated growth hormone deficiency (GHD) in childhood and adolescence: recent advances,”Endocr. Rev., 2014, 35 (3), 376– 432.

  • The Health Services Human Growth Hormone Committee. Comparison of intravenous insulin and oral clonidine tolerance tests for growth hormone secretion. Arch Dis Child. 1981, 56: 852-854.

  • Hoffman DJ. Growth retardation and metabolic programming: implications and consequences for adult health and disease risk. J Pediatr (Rio J). 2014, 90(4): 325-8.

  • Moayeri H and Aghighi Y. A prospective study of etiology of short stature in 426 short children and adolescents. Age 2004, 14 (1.7):13–3.

  • Colaco P and Desai M. Identification of a child with short stature. Indian Paediatr 1990, 27(11):1159–64.

  • Ayman A. Zayed Abdallah M, Beano Faris I. Haddadin. Prevalence of short stature, underweight, overweight, and obesity among school children in Jordan. BMC Public Health BMC series 2016;(16):1040.

  • Schroeder DG, Martorell R and Flores R. Infant and child growth and fatness and fat distribution in Guatemalan adults. Am J Epidemiol. 1999;149(2):177–85.

  • Dewey KG and Begum K. Long-term consequences of stunting in early life. Matern Child Nutr. 2011;7 Suppl 3:5–18.

  • Jawa A, Riaz SH, Assir MZK, Afreen B, Riaz A and Akram J. Causes of short stature in Pakistani children found at an Endocrine Center. Pak J Med Sci. 2016;32(6):1321-1325.

  • Waqar Rabbani M, Imran Khan W, Bilal Afzal A and Rabbani W. Causes of short stature identified in children presenting at a tertiary care hospital in Multan Pakistan. Pak J Med Sci 2013;29(1):53–7.

  • Awan TM, Sattar A and Khattak EG. Frequency of growth hormone deficiency in short statured children. J Coll Physicians Surg Pak 2005;15(5):295–8.

  • Mathew J, Ekaterina K, Kanakatte M, Prasanna K, and Harshal C. Challenges in the Diagnosis and Management of Growth Hormone Deficiency in India. International J. Endocrin. 2016; 111.

  • Gil-Ad I, Topper E, Laron Z. Oral clonidine as a GH stimulation test. Lancet 1979; 2, 278-280.

  • Menon P.S.N, Gupta P and Karmarkar MG .High and low dose clonidine tests for the diagnosis of growth hormone deficiency ; Indian Pediat. (31) February 1994;145-151.


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  • Study of Growth Hormone Response to Clonidine Stimulation in Short Stature with Growth Hormone Deficiency (GHD)

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Authors

Hind Salman Jasim
Baqubaa-Technical institute Middle Technical University (MTU), Iraq

Abstract


Background and Objective: Short stature is a condition when a person height is less two or more (standard deviations) (SD) than average height for persons of the same gender and chronologic age. There are different causations of "short stature" which extent from familial (genetic), "endocrine disorders, and chronic illnesses to idiopathic. Detecting and tending of curative disorders such anemia, nourished, disturbance of endocrine glands like hypothyroidism and shortage of growth hormone can cause attainability of predicted height. This study aimed to detect reasons of "short stature" in children and teenagers and to estimate the clonidine effectiveness on growth hormone level. Patients and Methods: In this study, 50 children and adolescent (1-18 years old) with symptoms of short stature where attended Al-Batool Teaching Obstetric Hospital at the period from March to September 2016, heights of all patients were estimated, growth hormone levels were evaluated before and after clonidine therapy using ELISA technique. Results: this study showed that all patients had height lower than normal (2 standard deviation below the mean). Growth hormone deficiency) was the main cause of "short stature" (44, 88 %) and there was significant differences in growth hormone level before and after clonidine intake (p ˂ 0.00). Conclusions: (Growth hormone deficiency) was the major cause of "short stature". Clonidine was effective therapy in stimulation and support the level of growth hormone.

Keywords


Short Stature, Growth Hormone, Clonidine.

References