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Association of TNF-308 Gene Polymorphism with Cervix Cancer Susceptibility among Women of Chhattisgarh


Affiliations
1 School of Studies in Anthropology, Pt. Ravishankar Shukla University, Raipur (C.G.), India
2 Department of Gynaecology, Dr. B.R. Ambedkar Memorial Hospital, Raipur (C.G.), India
     

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Tumour Necrosis Factor (TNF), being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumourigenesis. TNF has been shown to mediate carcinogenesis through induction of proliferation, invasion, and metastasis of tumour cells. Polymorphisms within TNF genes can result in pathogenesis and promoting malignant progression of cervix cancer. In the present hospital based case-control study, 230 cervix cancer patients (cases) and 230 controls were studied to determine the association of TNF-308 gene polymorphism with cervical cancer. TNF-308 null genotype showed significance distribution among cases and control (χ2=18.759, df =2, p = 0.00008). Women carrying the heterozygous A allele had a two-fold increased risk of developing cervix cancer (OR=1.775; 95% CI [1.178-2.674]) while the risk of cervix cancer raises to three-fold when A allele is preset in homozygous condition (OR=3.186; 95% CI [1.775-5.719]). These findings indicate that TNF-308 polymorphisms play crucial role in the development of cervix cancer.

Keywords

Cervix Cancer (CC), Case-Control Study, TNF-308 Gene Polymorphism, Homozygous and Heterozygous Alleles, Chhattisgarh.
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  • Association of TNF-308 Gene Polymorphism with Cervix Cancer Susceptibility among Women of Chhattisgarh

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Authors

Tulsi Rani Thakre
School of Studies in Anthropology, Pt. Ravishankar Shukla University, Raipur (C.G.), India
Abha Singh
Department of Gynaecology, Dr. B.R. Ambedkar Memorial Hospital, Raipur (C.G.), India
Mitashree Mitra
School of Studies in Anthropology, Pt. Ravishankar Shukla University, Raipur (C.G.), India

Abstract


Tumour Necrosis Factor (TNF), being an endogenous pyrogen, is able to induce fever, apoptotic cell death, cachexia, inflammation and to inhibit tumourigenesis. TNF has been shown to mediate carcinogenesis through induction of proliferation, invasion, and metastasis of tumour cells. Polymorphisms within TNF genes can result in pathogenesis and promoting malignant progression of cervix cancer. In the present hospital based case-control study, 230 cervix cancer patients (cases) and 230 controls were studied to determine the association of TNF-308 gene polymorphism with cervical cancer. TNF-308 null genotype showed significance distribution among cases and control (χ2=18.759, df =2, p = 0.00008). Women carrying the heterozygous A allele had a two-fold increased risk of developing cervix cancer (OR=1.775; 95% CI [1.178-2.674]) while the risk of cervix cancer raises to three-fold when A allele is preset in homozygous condition (OR=3.186; 95% CI [1.775-5.719]). These findings indicate that TNF-308 polymorphisms play crucial role in the development of cervix cancer.

Keywords


Cervix Cancer (CC), Case-Control Study, TNF-308 Gene Polymorphism, Homozygous and Heterozygous Alleles, Chhattisgarh.

References