Research Journal of Pharmacy and Technology

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Extraction, Characterization and Functionalization of Tamarind Gum


Affiliations
1 Department of Pharmaceutics, YSPM’S Yashoda Technical Campus, Faculty of Pharmacy, Wadhephata, Satara 415011, Maharashtra, India
2 Department of Pharmacology, School of Pharmacy, SRTM University, Nanded, 431606, Maharashtra, India
3 Department of Pharmacy, Government Polytechnic, National Highway No 6, Jalgaon 425002, Maharashtra, India
     

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The aim of present work was to extract, modify and characterize tamarind gum (TG), and explore its pharmaceutical applications. TG was extracted from tamarind kernel powder and tamarind seeds, and modified to carboxymethyl tamarind gum (CMTG) by using monochloroacetic acid. TG and CMTG were evaluated for pH, solubility, viscosity, swelling and powder characteristics, and characterized by Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, solid state 13C-nuclear magnetic resonance (13C-NMR) spectroscopy, differential scanning calorimeter (DSC) and X-ray diffractometer. TG was successfully extracted with yield more than 50%. Extracted gum was free from impurities like proteins and fats. Carboxymethylation of TG was confirmed by ATR-FTIR, solid state 13C-NMR and DSC study. The result of XRD study indicates that the amorphous nature of CMTG. Functionalization of TG into carboxymethyl derivative improved physicochemical properties of TG. CMTG showed high solubility, viscosity and swelling than TG. Results of the study revealed that carboxymethyl derivative can be potentially used for development of various drug delivery systems. It can be concluded that the CMTG has great potential as an excipient in pharmaceutical industry.

Keywords

Extraction, Characterization, Tamarind Gum, Carboxymethyl Tamarind Gum, Functionalization of Tamarind Gum.
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  • Laurienzo P, Fernandes JC, Colliec-Jouault S, Fitton JH. The Use of Natural Polysaccharides as Biomaterials. Biomed Res Int. 2015; 2015: 1–2.

  • Gupta S, Jain S, Rao G, Gupta V, Puri R. Tamarind kernel gum: An upcoming natural polysaccharide. Syst Rev Pharm. 2010;1(1):50–4.

  • Garner J, Park K. Chemically Modified Natural Polysaccharides to Form Gels. In: Polysaccharides. Cham: Springer International Publishing; 2015. p. 1555–82.

  • Singh R, Malviya R, Kumar Sharma P. Extraction and Characterization of Tamarind Seed Polysaccharide as a Pharmaceutical Excipient. Pharmacogn J. 2011;3(20):17–9.

  • Nayak AK, Pal D. Functionalization of Tamarind Gum for Drug Delivery. In: Functional Biopolymers. 2018. p. 25–56.

  • Prabhanjan H. Studies on Modified Tamarind Kernel Powder Part I: Preparation and Physicochemical Properties of Sodium Salt of Carboxymethyl Derivatives. Starke. 1989;11(S):409–14.

  • Rao P, Beri R. Acetylation of Tamarind Seed Jellose. Proc Indian Acad Sci - Sect A. 1955;42(4):199–203.

  • Prabhanjan H, Ali SZ. Studies on rheological properties of tamarind kernel powder, its derivatives and their blends with maize starch. Carbohydr Polym. 1995;28(3):245–53.

  • Kaur G, Mahajan M, Bassi P. Derivatized Polysaccharides: Preparation, Characterization, and Application as Bioadhesive Polymer for Drug Delivery. Int J Polym Mater. 2013;62(9):475–81.

  • Lang P, Masci G, Dentini M, Crescenzi V, Cooke D, Gidley MJ, et al. Tamarind seed polysaccharide: preparation, characterisation and solution properties of carboxylated, sulphated and alkylaminated derivatives. Carbohydr Polym. 1992;17(3):185–98.

  • Mali KK, Dhawale SC, Dias R, Havaldar V, Ghorpade V, Salunkhe N. Nasal Mucoadhesive In Situ Gel of Granisetron Hydrochloride using Natural Polymers. J Appl Pharm Sci. 2015;5(07):084–93.

  • Mali KK, Dhawale SC. Design and Optimization of Modified Tamarind Gum-based Floating-bioadhesive Tablets of Verapamil Hydrochloride. Asian J Pharm. 2016;10(4):2–8.

  • Mali KK, Dhawale SC, Dias RJ, Havaldar VD, Kavitake PR. Interpenetrating networks of carboxymethyl tamarind gum and chitosan for sustained delivery of aceclofenac. Marmara Pharm J. 2017 Oct 3;21(4):771–82.

  • Mali KK, Dhawale SC, Dias RJ. Synthesis and characterization of hydrogel films of carboxymethyl tamarind gum using citric acid. Int J Biol Macromol. 2017 Dec 11;105(Pt 1):463–70.

  • Mali KK, Dhawale SC, Dias RJ. Microemulsion Based Bioadhesive Gel of Itraconazole Using Tamarind Gum: In-vitro and Ex-vivo Evaluation. Marmara Pharm J. 2017 Jun 24;21(3):688–700.

  • Mali KK, Dhawale SC, Dias RJ, Dhane NS, Ghorpade VS. Citric Acid Crosslinked Carboxymethyl Cellulose-based Composite Hydrogel Films for Drug Delivery. Indian J Pharm Sci. 2018;80(4):657–67.

  • Sumathi S, Ray AR. Release behaviour of drugs from tamarind seed polysaccharide tablets. J Pharm Pharm Sci. 2002;5(1):12–8.

  • Rao P, Srivastava H. Tamarind. In: Whistler R, editor. Industrial Gums. 2nd ed. New York: Academic Press; 1973. p. 369–411.

  • Bansal J, Kumar N. Extraction and Evaluation of Tamarind Seed Polysaccharide as Pharmaceutical In situ Gel Forming System. Am J Sci Res. 2014;9(1):1–5.

  • Goyal P, Kumar V, Sharma P. Carboxymethylation of Tamarind kernel powder. Carbohydr Polym. 2007 Jun;69(2):251–5.

  • Ponnikornkit B, Ngamsalak C, Huanbutta K, Sittikijyothin W. Swelling Behaviour of Carboxymethylated Tamarind Gum. Adv Mater Res. 2015;1060:137–40.

  • Kulkarni R V., Mutalik S, Mangond BS, Nayak UY. Novel interpenetrated polymer network microbeads of natural polysaccharides for modified release of water soluble drug: In-vitro and in-vivo evaluation. J Pharm Pharmacol. 2012;64(4):530–40.

  • Pal S, Sen G, Mishra S, Dey RK, Jha U. Carboxymethyl tamarind: Synthesis, characterization and its application as novel drug-delivery agent. J Appl Polym Sci. 2008;110(1):392–400.

  • Kaur H, Ahuja M, Kumar S, Dilbaghi N. Carboxymethyl tamarind kernel polysaccharide nanoparticles for ophthalmic drug delivery. Int J Biol Macromol. 2012;50(3):833–9.


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  • Extraction, Characterization and Functionalization of Tamarind Gum

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Authors

Kailas K. Mali
Department of Pharmaceutics, YSPM’S Yashoda Technical Campus, Faculty of Pharmacy, Wadhephata, Satara 415011, Maharashtra, India
Shashikant C. Dhawale
Department of Pharmacology, School of Pharmacy, SRTM University, Nanded, 431606, Maharashtra, India
Remeth J. Dias
Department of Pharmacy, Government Polytechnic, National Highway No 6, Jalgaon 425002, Maharashtra, India

Abstract


The aim of present work was to extract, modify and characterize tamarind gum (TG), and explore its pharmaceutical applications. TG was extracted from tamarind kernel powder and tamarind seeds, and modified to carboxymethyl tamarind gum (CMTG) by using monochloroacetic acid. TG and CMTG were evaluated for pH, solubility, viscosity, swelling and powder characteristics, and characterized by Attenuated total reflectance-Fourier transform infrared (ATR-FTIR) spectroscopy, solid state 13C-nuclear magnetic resonance (13C-NMR) spectroscopy, differential scanning calorimeter (DSC) and X-ray diffractometer. TG was successfully extracted with yield more than 50%. Extracted gum was free from impurities like proteins and fats. Carboxymethylation of TG was confirmed by ATR-FTIR, solid state 13C-NMR and DSC study. The result of XRD study indicates that the amorphous nature of CMTG. Functionalization of TG into carboxymethyl derivative improved physicochemical properties of TG. CMTG showed high solubility, viscosity and swelling than TG. Results of the study revealed that carboxymethyl derivative can be potentially used for development of various drug delivery systems. It can be concluded that the CMTG has great potential as an excipient in pharmaceutical industry.

Keywords


Extraction, Characterization, Tamarind Gum, Carboxymethyl Tamarind Gum, Functionalization of Tamarind Gum.

References