Research Journal of Pharmacy and Technology

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New Simple Spectrophotometric Method for the Simultaneous Estimation of the Mixtures of Sildenafil and some Serotonin Reuptake Inhibitors


Affiliations
1 Analytical and Food Chemistry Department, University of Aleppo, Syrian Arab Republic
     

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This work presents a simple, reproducible, sensitive, generic and efficient method for simultaneous estimation. Vierordt’s method or simultaneous equation method was developed and validated for simultaneous estimation of two mixtures: Sildenafil and Duloxetine, Sildenafil and Fluoxetine, in the pure and pharmaceutical dosage form. The method was based on the measurement of absorbance at two wavelengths for each mixture in methanol. Calibration curves of all drugs were found to be linear. With good correlation coefficient values more than 0.99. The RSD values were found within limits and the recoveries ranging between 98 to 102% that confirms that the proposed method is accurate. This method for simultaneous estimation of these four mixtures is simple and economical and can be applied successfully for the simultaneous estimation of PDEs inhibitors and their combinations with some serotonin reuptake inhibitors in the pure and pharmaceuticals dosage forms.

Keywords

Simultaneous Estimation, Spectrophotometric, Vierordt’s Method, Sildenafil, Serotonin Reuptake Inhibitors.
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  • Hatzimouratidis K, Amar E, Eardley I, Giuliano F, Hatzichristou D, Montorsi F, Vardi Y, Wespes E. Guidelines on male sexual dysfunction: erectile dysfunction and premature ejaculation. European urology. 2010 May 1;57(5):804-14.

  • Mohee A, Eardley I. Medical therapy for premature ejaculation. Therapeutic advances in urology. 2011 Oct;3(5):211-22.

  • Waldinger MD. Ejaculation premature: Definition and drug treatment. Drugs. 2007;67:547-68.

  • Kendirci M, Salem E, Hellstrom WJ. Dapoxetine, a novel selective serotonin transport inhibitor for the treatment of premature ejaculation. Therapeutics and clinical risk management. 2007 Jun;3(2):277.

  • McMahon CG. Dapoxetine: a new option in the medical management of premature ejaculation. Therapeutic advances in urology. 2012 Oct;4(5):233-51.

  • Burton TD, Liday C. The comparison of combination SSRI and PDE-5 inhibitor therapy to SSRI monotherapy in men with premature ejaculation. Annals of Pharmacotherapy. 2011 Jul;45(7-8):1000-4. combined dosage form. World J. Pharm. Pharm. Sci. 2015 Jul 28;4(10):120-33.

  • Baker MM, Belal TS, Mahrous MS, Ahmed HM, Daabees HG. High‐performance liquid chromatography with diode array detection method for the simultaneous determination of seven selected phosphodiesterase‐5 inhibitors and serotonin reuptake inhibitors used as male sexual enhancers. Journal of separation science. 2016 May 1;39(9):1656-65.

  • Dudhrejiya A, Gandhi K, Maru M, Sheth N. Development and validation of stability indicating RP-HPLC method for simultaneous estimation of Sildenafil citrate and Fluoxetine in bulk and tablet dosage form. International Bulletin of Drug Research.; 20144(6):92-105.

  • Beckett A. H., Stenlake J. B.; Practical Pharmaceutical Chemistry, 4th Edition, Volume II, CBS, New Delhi, 1997; 278.

  • Kamal AH, El-Malla SF, Hammad SF. A Review on UV Spectrophotometric Methods for Simultaneous Multicomponent Analysis. European Journal of Pharmaceutical and Medical Research. 2016;3(2):348-60.


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  • New Simple Spectrophotometric Method for the Simultaneous Estimation of the Mixtures of Sildenafil and some Serotonin Reuptake Inhibitors

Abstract Views: 216  |  PDF Views: 0

Authors

Shaza Affas
Analytical and Food Chemistry Department, University of Aleppo, Syrian Arab Republic
Amir Alhaj Sakur
Analytical and Food Chemistry Department, University of Aleppo, Syrian Arab Republic

Abstract


This work presents a simple, reproducible, sensitive, generic and efficient method for simultaneous estimation. Vierordt’s method or simultaneous equation method was developed and validated for simultaneous estimation of two mixtures: Sildenafil and Duloxetine, Sildenafil and Fluoxetine, in the pure and pharmaceutical dosage form. The method was based on the measurement of absorbance at two wavelengths for each mixture in methanol. Calibration curves of all drugs were found to be linear. With good correlation coefficient values more than 0.99. The RSD values were found within limits and the recoveries ranging between 98 to 102% that confirms that the proposed method is accurate. This method for simultaneous estimation of these four mixtures is simple and economical and can be applied successfully for the simultaneous estimation of PDEs inhibitors and their combinations with some serotonin reuptake inhibitors in the pure and pharmaceuticals dosage forms.

Keywords


Simultaneous Estimation, Spectrophotometric, Vierordt’s Method, Sildenafil, Serotonin Reuptake Inhibitors.

References