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Design and Evaluation of Bigels Containing Flurbiprofen


Affiliations
1 Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore, Karnataka, India
     

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The present study was aimed of design and evaluation of bigel containing flurbiprofen. Bigels are interesting innovative two phase systems that have been recently proposed as structured system for delivery of active ingredients. They possess the advantages of both hydrogel and organogel. Organogel was prepared by pluronic lecithin and hydrogel was prepared using HPMC. Bigels were prepared by mixing of organogel and hydrogel in appropriate ratio. Organogel and hydrogel was evaluated for pH, viscosity, extrudability and spreadabilty. Formulation F3 from organogel and formulation H3 from hydrogel was selected as optimized formulations and was used for the preparation of bigel. The prepared bigel was evaluated for pH, viscosity, extrudability, spread ability, in vitro drug release studies, ex vivo permeation studies, stability studies and skin irritation test. All formulations of bigel showed extended release out of which formulation B3 was selected as the optimized formulation on the basis of evaluation parameters. In vitro permeation release was found to be 89.99% at the end of 8 hrs. The release kinetics of flurbiprofen bigel followed Higuchi model. The bigels were found to be stable and skin irritation studies on Wistar rats showed that the prepared bigels were compatible. Based on the encouraging results bigels containing flurbiprofen can be used as extended release system.

Keywords

Flurbiprofen, Organogel, Hydrogel, Bigel, HPMC.
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  • Tortora GJ, Derrickson B. Anatomy and physiology.1st ed. India edition, 2015, Wiley Publishers, pp. 125-137.

  • Enas Ahmed. Hydrogel: Preparation, characterization and applications: A review. J Adv Res. 6(1); 2015: 105–121.

  • Mahmoud Mokhtar I, Salma Hafez A, Mahmoud Mahdy M. Organogels, hydrogels and bigels as transdermal delivery systems for diltiazem hydrochloride. Asian J Pharma Sci. 8; 2013:48-57.

  • Lupi FR, Ahmed S, Greco V, Rossi CO, Baldino N. A rheological and micro structural characterization of bigels for cosmetic and pharmaceutical uses. Material Sci and Eng. 69; 2016:358-365.

  • Lupi FR, Gentle L, Baldino N. Olive oil and hyper thermal water bigels for cosmetic use. J Colloid and Interface Sci. 4(5); 2015:70-78.

  • Akhtar MF, Hafez SA, Mahdy MM. Organogels, hydrogels and bigels as transdermal delivery of diltiazem hydrochloride. Asian J Pharm Sci. 8; 2013:48-57.

  • Banks SR, Bajwa GS, Timmins P. The influence of substituted phenols on the sol: gel transition of hydroxypropyl methylcellulose (HPMC) aqueous solutions. Carbohydrate Polymers.101; 2014:1198-1204.

  • Makwana SB, Patel VA, Parmer SJ. Development and characterization of in situ gel for ophthalmic formulation containing ciprofloxacin hydrochloride. Res Pharm Sci. 6(1); 2016:1-6.

  • Chandira RM and Pradeep PA. Design, development and formulation of Antiacne Dermatological Gel. J Chem Pharm Res. 2(1); 2010:401-404.

  • Vikrant J, Sonali N. Formulation and evaluation of topical flurbiprofen gel using different gellying agents. World J Pharma Sci. 3(9); 2013:654-663.

  • Khan AW, Kotta S, Ansari SH, Sharma RK, Kumar A. Formulation, development, optimization and evaluation of aloe vera gel for wound healing. Pharmacogn Mag. 9(1); 2013: 6-10.

  • Singh VK, Anis A, Banarjee I. Preparation and characterization of novel carbopol based bigels for topical delivery of metronidazole for the treatment of bacterial vaginosis. Materials Sci and Eng. 44; 2014:151-158.

  • Shaikh IM. et al. Aceclofenac Organogels: In vitro and in vivo Characterization. Curr Drug Deliv. 6(1);2009: 1-7.

  • Sakarkar DM, Shrikande VN, Vyas JV, Mahajan N. Studies on formulation development, characterization and transdermal permeation of nimesulide from emulgel. Int J Pharm Excip. 16(5); 2004: 381-387.

  • Guleri KT, Preet KL. Formulation and evaluation of topical gel of aceclofenac. J Drug Deliv Therapeutics. 3(6); 2013: 51-53.

  • Tazrart A, Bolzinger MA, Moureau A, Molina T, Coudert S. Penetration and decontamination of americium-241 ex vivo using fresh and frozen pig skin. Chem Bio Inter. 267; 2017:40-47.

  • Nava G, Pinon E, Mendosa L, Mendosa N. Formulation and in vitro, ex vivo and in vivo evaluation of elastic liposomes for transdermal delivery of ketorolac tromethamine. Int J Pharm. 3; 2011:954-970.

  • Jain S, Goswami M, Bhandari A. Skin irritation study in transdermal patch of chitosan containing trazodane HCl on rat skin. Int J Res Pharm Bio Sci.2011;2(3)1082-1084.

  • WHO-GMP and ICH stability testing guidelines for drug products. The pharm Sci Pharm Pathway.2.72-2.79.


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  • Design and Evaluation of Bigels Containing Flurbiprofen

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Authors

R. Narayana Charyulu
Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore, Karnataka, India
Arjun Muaralidharan
Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore, Karnataka, India
D. S. Sandeep
Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences, Nitte (Deemed to be University) Paneer, Deralakatte, Mangalore, Karnataka, India

Abstract


The present study was aimed of design and evaluation of bigel containing flurbiprofen. Bigels are interesting innovative two phase systems that have been recently proposed as structured system for delivery of active ingredients. They possess the advantages of both hydrogel and organogel. Organogel was prepared by pluronic lecithin and hydrogel was prepared using HPMC. Bigels were prepared by mixing of organogel and hydrogel in appropriate ratio. Organogel and hydrogel was evaluated for pH, viscosity, extrudability and spreadabilty. Formulation F3 from organogel and formulation H3 from hydrogel was selected as optimized formulations and was used for the preparation of bigel. The prepared bigel was evaluated for pH, viscosity, extrudability, spread ability, in vitro drug release studies, ex vivo permeation studies, stability studies and skin irritation test. All formulations of bigel showed extended release out of which formulation B3 was selected as the optimized formulation on the basis of evaluation parameters. In vitro permeation release was found to be 89.99% at the end of 8 hrs. The release kinetics of flurbiprofen bigel followed Higuchi model. The bigels were found to be stable and skin irritation studies on Wistar rats showed that the prepared bigels were compatible. Based on the encouraging results bigels containing flurbiprofen can be used as extended release system.

Keywords


Flurbiprofen, Organogel, Hydrogel, Bigel, HPMC.

References