Research Journal of Pharmacy and Technology

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Formulation and In-Vitro Evaluation of FDC Bilayer Matrix Tablets Containing Telmisartan as Sustained Release and Hydrochlorothiazide as Immediate Release


Affiliations
1 JK College of Pharmacy, Bilaspur, CG, 495001, India
2 Department of Pharmaceutics, Jamia Hamdard, New Delhi, 110062, India
     

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The aim of the presented work was formulation and in-vitro evaluation of bilayer tablets containing telmisartan as sustained release (SR) and hydrochlorothiazide as immediate release (IR) using HPMC. Tablets were evaluated via various quality control tests and in-vitro drug release studies. Drug release study was carried out hydrochloric acid buffer of pH 1.2 (0.1N) using USP paddle apparatus. The validated HPLC-UV method was applied to determine the amount of drugs released at different time intervals. Prepared tablets showed extended sustain release of telmisartan over a period of 20 h and hydrochlorothiazide as immediate release within 30 min.

Keywords

Bilayer Tablet, Telmisartan, Hydrochlorothiazide, Sustained Release, Immediate Release.
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  • Formulation and In-Vitro Evaluation of FDC Bilayer Matrix Tablets Containing Telmisartan as Sustained Release and Hydrochlorothiazide as Immediate Release

Abstract Views: 156  |  PDF Views: 3

Authors

Hamid Khan
JK College of Pharmacy, Bilaspur, CG, 495001, India
Mushir Ali
Department of Pharmaceutics, Jamia Hamdard, New Delhi, 110062, India
Alka Ahuja
Department of Pharmaceutics, Jamia Hamdard, New Delhi, 110062, India
Javed Ali
Department of Pharmaceutics, Jamia Hamdard, New Delhi, 110062, India

Abstract


The aim of the presented work was formulation and in-vitro evaluation of bilayer tablets containing telmisartan as sustained release (SR) and hydrochlorothiazide as immediate release (IR) using HPMC. Tablets were evaluated via various quality control tests and in-vitro drug release studies. Drug release study was carried out hydrochloric acid buffer of pH 1.2 (0.1N) using USP paddle apparatus. The validated HPLC-UV method was applied to determine the amount of drugs released at different time intervals. Prepared tablets showed extended sustain release of telmisartan over a period of 20 h and hydrochlorothiazide as immediate release within 30 min.

Keywords


Bilayer Tablet, Telmisartan, Hydrochlorothiazide, Sustained Release, Immediate Release.