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Kumar, Anil
- Anti-convulsant Activity of Benincasa hispida Fruit Methanol Extract
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Journal of Natural Remedies, Vol 4, No 2 (2004), Pagination: 195-198Abstract
Objective: To study the effect of methanol extract of Benincasa hispida fruit in various convulsive models in mice. Methods: Methanol extract of B. hispida was evaluated using chemo-convulsive agents such as pentylenetetrazole, strychnine and picrotoxin, and maximal electro seizures (MES) model in mice at dose levels ranging from 0.2 - 1g/kg, i.p. Results: The extract at 0.2-0.6 g/kg significantly (p<0.001) inhibited the hind limb extension induced by MES and at 0.4 and 0.6 g/kg, the extract significantly (p<0.01) increased the latency of convulsion and death induced by pentylenetetrazole and strychnine. However even at 1 g/kg, the extract failed to protect the convulsion induced by picrotoxin. Conclusion: On the basis of the present finding, we can conclude that the fruit B. hispida possess potential anticonvulsant activity.Keywords
Benincasa hispida, Pentylenetetrazole, Picrotoxin, Strychnine, Mes, Anticonvulsant Activity- Screening of Fruit of Diospyros montana for Anti-filarial Activity
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PDF Views:417
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Journal of Natural Remedies, Vol 9, No 1 (2009), Pagination: 56-61Abstract
Objective: To screen the potential antifilarial activity of petroleum and alcoholic extracts prepared from fruit of Diospyros montana. Materials and Methods: In vitro study was carried out to see the effect of extracts on both the whole worm(w.w). preparation and nerve muscle (n.m) preparation of Setaria cervi, on the survival of microfilariae. Results: Petroleum extract produced initial stimulation followed by reversible paralysis in whole worm The initial stimulation is not seen with petroleum extract on nerve muscle preparation. The alcoholic extract caused reversible paralysis in whole worm whereas irreversible in nerve muscle preparation. Conclusion: Fruit of D. montana was found to possess potential antifilarial activity.Keywords
Antifilarial, Screening, Diospyros Montana, Setaria- Effect of Cuminum Cyminum L. Seed Extracts on Pain and Inflammation
Abstract Views :298 |
PDF Views:188
Authors
Affiliations
1 Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh-202002, IN
1 Department of Pharmacology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh-202002, IN