A Study on the Anti-hyperglycaemic Effect of Premna corymbosa Rottl. Roots

Objective: To study the antihyperglycaemic activity of the ethanol (50% v/v) ischolar_main extract of Premna corymbosa Rottl. on albino rats. Materials and methods: Antihyperglycaemic activity of the ischolar_main extract was evaluated by using both normoglycaemic and alloxan induced hyperglycaemic rats at dose levels of 200 and 400 mg/kg respectively through oral route. Results: The extract was found to produce marked reduction in blood glucose concentration at tested dose levels in a dose dependant manner in both the models. However, in normoglycaemic animals, the extract at 400 mg/kg dose level produced significant reduction of blood glucose at the 8^th hour of administration. Conclusion: The results of the present study justify the use of the ischolar_mains of the plant for treating diabetes as suggested in folklore remedies.