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A Pre-clinical Study of Jeerakadi Lepa against Indian Red Scorpion Venom Poisoning


Affiliations
1 Manjushree Research Institute in Ayurvedic Science, Gujarat Ayurved University, Piplaj, Jamnagar, Gandhinagar - 382610, Gujarat, India
2 Dr. J. J. Magdum Ayurvedic Medical College, Maharashtra University of Health Sciences, Jaysingpur – Shirol Rd., Nashik, Jaysingpur - 416101, India
 

Scorpion stings are very common in India, especially in the Konkan region of Maharashtra state. Scorpion stings show various signs and symptoms. A preclinical study to validate the efficacy of an Ayurvedic preparation called Jeerakadi Lepa was done in Swiss albino mice. A total of 18 Swiss albino mice (n = 18) were divided into 3 groups: the control group (n = 6), the standard group (n = 6) and the experimental group (n = 6). Only Indian red scorpion venom was administered by the SC route in the control group. In contrast, the venom was administered by SC in the standard group, followed by an oral tablet. Prazosin, and in the experimental group, the venom was administered by SC route, followed by local Jeerakadi Lepa. Kruskal-Wallis’s test was applied at a 95% confidence interval to assess various toxicity parameters like lacrimation, salivation, etc. The P-value was 0.04433 in toxicity symptoms (P < 0.05), but it was 0.3366 (P > 0.05) in the number of deaths of Swiss albino mice in the above groups. It was concluded that Jeerakadi Lepa effectively eliminated all the signs and symptoms of toxicity due to scorpion venom in Swiss albino mice. Still, it should not be used independently among humans.

Keywords

Cumin Seeds, Indian Red Scorpion Poisoning, Jeerakadi Lepa, Mesobuthus tumulus, Preclinical Study, Vrischikdansha.
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  • A Pre-clinical Study of Jeerakadi Lepa against Indian Red Scorpion Venom Poisoning

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Authors

Pallavi Satyajit Kulkarni
Manjushree Research Institute in Ayurvedic Science, Gujarat Ayurved University, Piplaj, Jamnagar, Gandhinagar - 382610, Gujarat, India
Narayan Gajanan Gramopadhye
Dr. J. J. Magdum Ayurvedic Medical College, Maharashtra University of Health Sciences, Jaysingpur – Shirol Rd., Nashik, Jaysingpur - 416101, India
Satyajit Pandurang Kulkarni
Manjushree Research Institute in Ayurvedic Science, Gujarat Ayurved University, Piplaj, Jamnagar, Gandhinagar - 382610, Gujarat, India

Abstract


Scorpion stings are very common in India, especially in the Konkan region of Maharashtra state. Scorpion stings show various signs and symptoms. A preclinical study to validate the efficacy of an Ayurvedic preparation called Jeerakadi Lepa was done in Swiss albino mice. A total of 18 Swiss albino mice (n = 18) were divided into 3 groups: the control group (n = 6), the standard group (n = 6) and the experimental group (n = 6). Only Indian red scorpion venom was administered by the SC route in the control group. In contrast, the venom was administered by SC in the standard group, followed by an oral tablet. Prazosin, and in the experimental group, the venom was administered by SC route, followed by local Jeerakadi Lepa. Kruskal-Wallis’s test was applied at a 95% confidence interval to assess various toxicity parameters like lacrimation, salivation, etc. The P-value was 0.04433 in toxicity symptoms (P < 0.05), but it was 0.3366 (P > 0.05) in the number of deaths of Swiss albino mice in the above groups. It was concluded that Jeerakadi Lepa effectively eliminated all the signs and symptoms of toxicity due to scorpion venom in Swiss albino mice. Still, it should not be used independently among humans.

Keywords


Cumin Seeds, Indian Red Scorpion Poisoning, Jeerakadi Lepa, Mesobuthus tumulus, Preclinical Study, Vrischikdansha.

References





DOI: https://doi.org/10.18311/jnr%2F2023%2F29361