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Ethnopharmacology of Genus Rubus: Modern Science from Ancient Science


Affiliations
1 Department of Pharmacology, Noida Institute of Engineering & Technology (Pharmacy Institute), 19, Knowledge Park-II, Institutional Area, Greater Noida - 201306, Uttar Pradesh, India
2 Gautam Buddha College of Pharmacy, Bijnour Road, Lucknow - 226008, Uttar Pradesh, India
3 Orlean College of Pharmacy, Knowledge Park-III, Institutional Area, Greater Noida - 201308, Uttar Pradesh, India
 

From the prehistoric, ancient age to the modern-day, genus Rubus species are already known for their healing properties such as in neurodegenerative and psychological disorders, cancer, diarrhoea, colic pain, diabetes, nephrological, and inflammatory disorders. Based on their phytochemistry and pharmacology it is an attempt to achieve a greater knowledge of the biological significance of these herbal medicinal plants. The ultimate aim of this review is to deliver the magnification of research at the cellular and molecular level in the management of nervous breakdowns and other diseases. An exhaustive literature search was performed by online databases such as Springer, Scopus, and Elsevier. In this review, the different novel medicinal plants belong to the genus Rubus, used to treat enormous ailments based on traditional and literature search, their potential bioactive species belong to the same genus.

 

Keywords

Ethnomedicine, Pharmacological Properties, Phytochemistry, Rubus, Traditional Uses, Translational Value.
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  • Perumal Samy R, Ignacimuthu S. Antibacterial activity of some folklore medicinal plants used by tribals in Western Ghats of India. J. Ethnopharmacol. 2000; 69(1):63-71. https://doi.org/10.1016/S0378-8741(98)00156-1 DOI: https://doi.org/10.1016/S0378-8741(98)00156-1

  • Fabricant DS, Farnsworth NR. The value of plants used in traditional medicine for drug discovery. Environ Health Perspect. 2001; 109(1):69-75. https://doi.org/10.1289/ ehp.01109s169 DOI: https://doi.org/10.1289/ehp.01109s169

  • Williamson G. Possible effects of dietary polyphenols on sugar absorption and digestion. Molecular Nutrition and Food Research, Mol Nutr Food Res. 2013; 57:48-57. https:// doi.org/10.1002/mnfr.201200511 DOI: https://doi.org/10.1002/mnfr.201200511

  • Krishna G, Ying Z, Gomez-Pinilla F. Blueberry Supplementation Mitigates Altered Brain Plasticity and Behavior after Traumatic Brain Injury in Rats. Mol Nutr Food Res. 2019; 63(15):23-32. https://doi.org/10.1002/ mnfr.201801055 DOI: https://doi.org/10.1002/mnfr.201801055

  • Kalt W, Blumberg JB, McDonald JE, Vinqvist-Tymchuk MR, Fillmore SAE, Graf BA, Leary JMO, Milbury PE. Identification of anthocyanins in the liver, eye, and brain of blueberry-fed pigs. J. Agric. Food Chem. 2008; 53(3):705- 12. https://doi.org/10.1021/jf071998l DOI: https://doi.org/10.1021/jf071998l

  • Casadesus G, Shukitt-Hale B, Stellwagen HM, Zhu X, Lee HG, Smith MA. Modulation of hippocampal plasticity and cognitive behavior by short-term blueberry supplementation in aged rats. Nutr Neurosci. 2004; 7(5-6):309-16. https://doi.org/10.1080/10284150400020482 DOI: https://doi.org/10.1080/10284150400020482

  • Sangiovanni E, Vrhovsek U, Rossoni G, Colombo E, Brunelli C, Brembati L, et al. Ellagitannins from Rubus Berries for the Control of Gastric Inflammation: In vitro and In vivo Studies. Bassaganya-Riera J, editor. PLoS One. 2013; 8(8):1- 12. https://doi.org/10.1371/journal.pone.0071762 DOI: https://doi.org/10.1371/journal.pone.0071762

  • Acosta-Montoya O, Vaillant F, Cozzano S, Mertz C, Perez AM, Castro M V. Phenolic content and antioxidant capacity of tropical highland blackberry (Rubus adenotrichus Schltdl.) during three edible maturity stages. Food Chem. 2010; 119(4):1497-501. https://doi.org/10.1016/j.foodchem. 2009.09.032 DOI: https://doi.org/10.1016/j.foodchem.2009.09.032

  • Bolson M, Hefler SR, Dall’Oglio Chaves EI, Gasparotto Junior A, Cardozo Junior EL. Ethno-medicinal study of plants used for treatment of human ailments, with residents of the surrounding region of forest fragments of Parana, Brazil. J Ethnopharmacol. 2015; 23:161, 1-10. https://doi. org/10.1016/j.jep.2014.11.045 DOI: https://doi.org/10.1016/j.jep.2014.11.045

  • Hussein SAM, Ayoub NA, Nawwar MAM. Caffeoyl sugar esters and an ellagitannin from Rubus sanctus. Phytochemistry. 2003; 63(8):905-11. https://doi. org/10.1016/S0031-9422(03)00331-5 DOI: https://doi.org/10.1016/S0031-9422(03)00331-5

  • Meng XL, Yang JY, Chen GL, Zhang LJ, Wang LH, Li J, Wang JM, Wu CF. RV09, a novel resveratrol analogue, inhibits NO and TNF-α production by LPS-activated microglia. Int Immunopharmacol. 2008; 8(8):1074-82. https://doi. org/10.1016/j.intimp.2008.03.011 DOI: https://doi.org/10.1016/j.intimp.2008.03.011

  • Branquinho Andrade P, Grosso C, Valentao P, Bernardo J. Flavonoids in Neurodegeneration: Limitations and Strategies to Cross CNS Barriers. Curr Med Chem. 2016; 23(36):4151-74. https://doi.org/10.2174/092986732366616 0809094934 DOI: https://doi.org/10.2174/0929867323666160809094934

  • Fernandez-Demeneghi R, Rodriguez-Landa JF, Guzman- Geronimo RI, Acosta-Mesa HG, Meza-Alvarado E, Vargas-Moreno I, et al. Effect of blackberry juice (Rubus fruticosus L.) on anxiety-like behaviour in Wistar rats. Int J Food Sci Nutr. 2019; 70(7):856-67. https://doi.org/10.1080/ 09637486.2019.1580680 DOI: https://doi.org/10.1080/09637486.2019.1580680

  • Tsuda T, Horio F, Osawa T. Dietary cyanidin 3-O-β-dglucoside increases ex vivo oxidation resistance of serum in rats. Lipids. 1998; 33(6):583-8. https://doi.org/10.1007/ s11745-998-0243-5 DOI: https://doi.org/10.1007/s11745-998-0243-5

  • Galli RL, Shukitt-Hale B, Youdim KA, Joseph JA. Fruit Polyphenolics and Brain Aging Nutritional Interventions Targeting Age-related Neuronal and Behavioral Deficits. Ann. N.Y. Acad. Sci. 2002; 9(59):32-34. https://doi. org/10.1111/j.1749-6632.2002.tb02089.x

  • Patel A, Rojas-Vera J, Dacke C. Therapeutic Constituents and Actions of Rubus Species. Curr Med Chem. 2012; 11(11):1501-12. https://doi.org/10.2174/0929867043365143 DOI: https://doi.org/10.2174/0929867043365143

  • Zia-Ul-Haq M, Riaz M, De Feo V, Jaafar HZ, Moga M. Rubus fruticosus L.: Constituents, biological activities and health related uses. Molecules. 2014; 19(8):10998-1029. https://doi.org/10.3390/molecules190810998 DOI: https://doi.org/10.3390/molecules190810998

  • Akkol EK, Suntar I, Koca U, Keleş H. Wound healing activity of Rubus sanctus Schreber (Rosaceae): Preclinical study in animal models. Evidence-based Complement Altern Med. 2011; 2011:1-6. https://doi.org/10.1093/ecam/nep137 DOI: https://doi.org/10.1093/ecam/nep137

  • Kumar PR, Vaidhyalingam V. Characterization and Evaluation of Anti-Convulsant Activity of Rubus racemosus. Int J of Pharmacog and Phytochemical Res. 2010; 2(3): 26-29.

  • Shankar Sharma U. Nephroprotective evaluation of Rubus ellipticus (smith) fruits extracts against cisplatin and gentamicin induced renal-toxicity in rats. J Pharm Res. 2010; 4(1):285-7.

  • Ilic NM, Dey M, Poulev AA, Logendra S, Kuhn PE, Raskin I. Anti-inflammatory activity of grains of paradise (Aframomum melegueta Schum) extract. J Agric Food Chem. 2014; 62(43):10452-7. https://doi.org/10.1021/ jf5026086 DOI: https://doi.org/10.1021/jf5026086

  • Zhang Y, Wang L, Jiang Z, Xu L. Antioxidant activities and main active compounds of solvent extracts from Rubus pungens var. oldhamii. J Biobased Mater Bioenergy. 2016; 10(5):354-61. https://doi.org/10.1166/jbmb.2016.1611 DOI: https://doi.org/10.1166/jbmb.2016.1611

  • Andres-Lacueva C, Shukitt-Hale B, Galli RL, Jauregui O, Lamuela-Raventos RM, Joseph JA. Anthocyanins in aged blueberry-fed rats are found centrally and may enhance memory. Nutr Neurosci. 2005; 8(2):111-20. https://doi. org/10.1080/10284150500078117 DOI: https://doi.org/10.1080/10284150500078117

  • Aviram M, Volkova N, Coleman R, Dreher M, Reddy MK, Ferreira D, Rosenblat M. Pomegranate phenolics from the peels, arils and flowers are antiatherogenic: studies in vivo in atherosclerotic apolipoprotein E-deficient (E0) mice and in vitro in cultured macrophages and lipoproteins. J. Agric. Food Chem. 2008; 56(3):1148-57. https://doi.org/10.1021/ jf071811q DOI: https://doi.org/10.1021/jf071811q

  • Sleight P, La Rovere MT, Mortara A, Pinna G, Maestri R, Leuzzi S, Bianchini B, Tavazzi L, Bernardi L. Physiology and pathophysiology of heart rate and blood pressure variability in humans: is power spectral analysis largely an index of baroreflex gain? Clin Sci (Lond). 1995; 88(1):103-9. https:// doi.org/10.1042/cs0880103 DOI: https://doi.org/10.1042/cs0880103

  • Ajagbonna OP, Mojiminiyi FB, Sofola OA. Relaxant effects of the aqueous leaf extract of Cassia occidentalis on rat aortic rings. Afr. J. Biomed. Res. 2001; 4(3):127-129. https:// doi.org/10.4314/ajbr.v4i3.53893 DOI: https://doi.org/10.4314/ajbr.v4i3.53893

  • Su XH, Duan R, Sun YY, Wen JF, Kang DG, Lee HS, Cho KW, Jin SN. Cardiovascular effects of ethanol extract of Rubus chingii Hu (Rosaceae) in rats: an in vivo and in vitro approach. J Physiol Pharmacol. 2014; 65(3):417-24.

  • Zeng H jin, Liu Z, Wang Y ping, Yang D, Yang R, Qu L bo. Studies on the anti-aging activity of a glycoprotein isolated from Fupenzi (Rubus chingii Hu.) and its regulation on klotho gene expression in mice kidney. Int J Biol Macromol. 2018; 119:470-6. https://doi.org/10.1016/j. ijbiomac.2018.07.157 DOI: https://doi.org/10.1016/j.ijbiomac.2018.07.157

  • Grochowski DM, Paduch R, Wiater A, Dudek A, Pleszczyńska M, Tomczykowa M, Granica S, Polak P, Tomczyk M. In vitro anti-proliferative and antioxidant effects of extracts from Rubus caesius leaves and their quality evaluation. Evidence-based Complement Altern. Med. 2016; 1-8:45-7. https://doi.org/10.1155/2016/5698685 DOI: https://doi.org/10.1155/2016/5698685

  • Rajendran P, Ho E, Williams DE, Dashwood RH. Dietary phytochemicals, HDAC inhibition, and DNA damage/ repair defects in cancer cells. Clin Epigenetics. 2011; 3(1):4-9.https://doi.org/10.1186/1868-7083-3-4 DOI: https://doi.org/10.1186/1868-7083-3-4

  • Cetojevic-Simin DD, Ranitovic AS, Cvetkovic DD, Markov SL, Vincic MN, Djilas SM. Bioactivity of blackberry (Rubus fruticosus L.) pomace: Polyphenol content, radical scavenging, antimicrobial and antitumor activity. Acta Period Technol. 2017; 48:63-76. https://doi.org/10.2298/ APT1748063C DOI: https://doi.org/10.2298/APT1748063C

  • Ceci C, Tentori L, Atzori M, Lacal P, Bonanno E, Scimeca M, et al. Ellagic Acid Inhibits Bladder Cancer Invasiveness and in vivo Tumor Growth. Nutrients. 2016; 8(11):74-4. https://doi.org/10.3390/nu8110744 DOI: https://doi.org/10.3390/nu8110744

  • Borges G, Degeneve A, Mullen W, Crozier A. Identification of Flavonoid and Phenolic Antioxidants in Black Currants, Blueberries, Raspberries, Red Currants, and Cranberries. 2010; 58(7):3901-9.https://doi.org/10.1021/jf902263n DOI: https://doi.org/10.1021/jf902263n

  • Klewicka E, Sojka M, Klewicki R, Kołodziejczyk K, Lipinska L, Nowak A. Ellagitannins from Raspberry (Rubus idaeus L.) Fruit as Natural Inhibitors of Geotrichum candidum. Molecules. 2016; 21(7):90-8. https://doi.org/10.3390/molecules21070908 DOI: https://doi.org/10.3390/molecules21070908


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  • Ethnopharmacology of Genus Rubus: Modern Science from Ancient Science

Abstract Views: 93  |  PDF Views: 73

Authors

Saumya Das
Department of Pharmacology, Noida Institute of Engineering & Technology (Pharmacy Institute), 19, Knowledge Park-II, Institutional Area, Greater Noida - 201306, Uttar Pradesh, India
Avijit Mazumder
Department of Pharmacology, Noida Institute of Engineering & Technology (Pharmacy Institute), 19, Knowledge Park-II, Institutional Area, Greater Noida - 201306, Uttar Pradesh, India
Neha Sahu
Gautam Buddha College of Pharmacy, Bijnour Road, Lucknow - 226008, Uttar Pradesh, India
Manas Kumar Das
Orlean College of Pharmacy, Knowledge Park-III, Institutional Area, Greater Noida - 201308, Uttar Pradesh, India
Suniti Chand
Department of Pharmacology, Noida Institute of Engineering & Technology (Pharmacy Institute), 19, Knowledge Park-II, Institutional Area, Greater Noida - 201306, Uttar Pradesh, India
Hrithik Gupta
Department of Pharmacology, Noida Institute of Engineering & Technology (Pharmacy Institute), 19, Knowledge Park-II, Institutional Area, Greater Noida - 201306, Uttar Pradesh, India
Ankit Kumar
Department of Pharmacology, Noida Institute of Engineering & Technology (Pharmacy Institute), 19, Knowledge Park-II, Institutional Area, Greater Noida - 201306, Uttar Pradesh, India

Abstract


From the prehistoric, ancient age to the modern-day, genus Rubus species are already known for their healing properties such as in neurodegenerative and psychological disorders, cancer, diarrhoea, colic pain, diabetes, nephrological, and inflammatory disorders. Based on their phytochemistry and pharmacology it is an attempt to achieve a greater knowledge of the biological significance of these herbal medicinal plants. The ultimate aim of this review is to deliver the magnification of research at the cellular and molecular level in the management of nervous breakdowns and other diseases. An exhaustive literature search was performed by online databases such as Springer, Scopus, and Elsevier. In this review, the different novel medicinal plants belong to the genus Rubus, used to treat enormous ailments based on traditional and literature search, their potential bioactive species belong to the same genus.

 

Keywords


Ethnomedicine, Pharmacological Properties, Phytochemistry, Rubus, Traditional Uses, Translational Value.

References





DOI: https://doi.org/10.18311/jnr%2F2022%2F29886