Journal of Natural Remedies

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Therapeutic Effect of Aloe vera on Croton Oil Induced Hemorrhoids


Affiliations
1 Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Potheri, Chengalpattu – 603203, Tamil Nadu, India
 

Hemorrhoids are vascular structures in the anal canal with swollen veins in the lowest part of the rectum/anus. Till date, there is no specific treatment available for different grades of hemorrhoids. However, it is evident that lesser invasive options are to have opted for at the earliest along with conservative measures such as analgesics and anti-inflammatory agents. The study evaluates the efficacy of gel obtained from Aloe barbadensis Miller in treating hemorrhoids in a croton oil- induced Wistar rat model. Animals were allocated into 5 groups. Group I and II served as the normal and negative control, Group III as standard, and Group IV and V received an oral route and a topical route respectively. Biochemical parameters such as TNF-α and IL-6 were estimated in each group after the therapy of 5 days. Quantitative estimation of edema was done by determining the Evans blue dye concentration in the plasma exudates in recto-anal tissue. The recto-anal coefficient was estimated as a direct measure of inflammation. Histopathological variations among the groups were analyzed. Statistical analysis of the data affirms the curative effect of aloe vera on Hemorrhoids. Results demonstrate that aloe gel is much more effective when compared to Pilex ointment which was used as standard (p<0.05). However, oral preparation was not found to be effective in mitigating the disease as that standard (p>0.05).


Keywords

Aloe barbadensis Miller, Anti-inflammatory, Evans Blue Dye, Hemorrhoids.
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  • Therapeutic Effect of Aloe vera on Croton Oil Induced Hemorrhoids

Abstract Views: 163  |  PDF Views: 91

Authors

Swathi Suresh
Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Potheri, Chengalpattu – 603203, Tamil Nadu, India
Ankul Singh
Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Potheri, Chengalpattu – 603203, Tamil Nadu, India
Chitra Vellapandian
Department of Pharmacology, SRM College of Pharmacy, SRM Institute of Science and Technology, Potheri, Chengalpattu – 603203, Tamil Nadu, India

Abstract


Hemorrhoids are vascular structures in the anal canal with swollen veins in the lowest part of the rectum/anus. Till date, there is no specific treatment available for different grades of hemorrhoids. However, it is evident that lesser invasive options are to have opted for at the earliest along with conservative measures such as analgesics and anti-inflammatory agents. The study evaluates the efficacy of gel obtained from Aloe barbadensis Miller in treating hemorrhoids in a croton oil- induced Wistar rat model. Animals were allocated into 5 groups. Group I and II served as the normal and negative control, Group III as standard, and Group IV and V received an oral route and a topical route respectively. Biochemical parameters such as TNF-α and IL-6 were estimated in each group after the therapy of 5 days. Quantitative estimation of edema was done by determining the Evans blue dye concentration in the plasma exudates in recto-anal tissue. The recto-anal coefficient was estimated as a direct measure of inflammation. Histopathological variations among the groups were analyzed. Statistical analysis of the data affirms the curative effect of aloe vera on Hemorrhoids. Results demonstrate that aloe gel is much more effective when compared to Pilex ointment which was used as standard (p<0.05). However, oral preparation was not found to be effective in mitigating the disease as that standard (p>0.05).


Keywords


Aloe barbadensis Miller, Anti-inflammatory, Evans Blue Dye, Hemorrhoids.

References





DOI: https://doi.org/10.18311/jnr%2F2022%2F29777