Journal of Natural Remedies

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A Review on the Possible Therapeutic Intervention by Herbal Remedies on Antipsychotic Drugs Induced Metabolic Disorder


Affiliations
1 Sumandeep Nursing College, Sumandeep Vidyapeeth Deemed to be University, Pipariya, Vadodara - 391760, India
2 Department of General Medicine, S.B.K.S. MI & RC, Sumandeep Vidyapeeth Deemed to be University, Pipariya, Vadodara - 391760, India
3 Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Pipariya, Vadodara - 391760, India
 

This review is the compilation of some of the natural products which are effective in treating diabetes, lipid abnormalities and cardiovascular diseases. We also discussed metabolic disorder associated with antipsychotic drugs. Currently, there are no equivocal evidence to demonstrate the effectiveness of herbal drugs in treating metabolic disorders induced by antipsychotic drugs. Therefore, there is a need of extensive research work to be carried out to explore the possibilities of therapeutic intervention of herbal drugs in antipsychotics induced metabolic disorders.


Keywords

Antipsychotic Drugs, Disorder, Herbal Drugs, Metabolism
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  • Expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. summary of the second report of the National Cholesterol Education Program (NCEP) Expert Panel on Detection, Evaluation, and Treatment of High Blood Cholesterol in Adults (Adult Treatment Panel II). JAMA.1993; 269:3015–23. https://doi.org/10.1001/ jama.1993.03500230097036

  • Balaraman R, Parmar G, Maheshwari RA, Anuj SD. A review on the biological effects of some natural products. J. Nat. Remedies. 2020; 20(3):117–27. https://doi.org/10.18311/ jnr/2020/25581

  • Huang TH, Kota BP, Razmovski V, Roufogalis BD. Herbalor natural medicines as modulators of peroxisome proliferator activated receptors and related nuclear receptors for ther- apy of metabolic syndrome. Basic Clin. Pharmacol. Toxicol. 2005; 96(1):3–14. https://doi.org/10.1111/j.1742-7843.2005. pto960102.x. PMid:15667590

  • Razavi BM, Hosseinzadeh H. A review of the effects of Nigella sativa L. and its constituent, thymoquinone, in metabolic syndrome. J. Endocrinol. Invest. 2014; 37(11):1031–40. https://doi.org/10.1007/s40618-014-0150- 1. PMid:25125023

  • Vogler BK, Ernst E. Aloe vera: A systematic review of its clinical effectiveness. Br. J. Gen. Pract. 1999; 49(447):823–8.

  • Pothuraju R, Sharma RK, Onteru SK, Singh S, Hussain SA. Hypoglycemic and hypolipidemic effects of Aloe vera extract preparations: A review. Phytother Res. 2016; 30(2):200–7. https://doi.org/10.1002/ptr.5532. PMid:26666199

  • Saleem R, Faizi S, Siddiqui BS, Ahmed M, Hussain SA, Qazi A, Hasnain SN. Hypotensive effect of chemical constituents from Aloe barbadensis. Planta Medica. 2001; 67(8):757–60. https://doi.org/10.1055/s-2001-18348. PMid:11731923

  • Misawa E, Tanaka M, Nabeshima K, Nomaguchi K, Yamada M, Toida T, et al. Administration of dried Aloe vera gel pow- der reduced body fat mass in Diet‐induced Obesity (DIO) rats. J. Nutr. Sci. Vitaminol. 2012; 58(3):195–201. https:// doi.org/10.3177/jnsv.58.195. PMid:22878390

  • Pugh N, Ross SA, El Sohly MA, Pasco DS. Characterization of aloeride, a new high molecular weight polysaccharide from Aloe vera with potent immunostimulatory activ- ity. J. Agric. Food Chem. 2001; 49(2):1030–4. https://doi. org/10.1021/jf001036d. PMid:11262067

  • Sharma P, Kharkwal A, Kharkwal H, Abdin M, Varma A. A review on pharmacological properties of Aloe vera. Int. J. Pharm. Sci. Rev. Res. 2014; 29(2):31–7.

  • Parihar MS, Chaudhary M, Shetty R, Hemnani T. Susceptibility of hippocampus and cerebral cortex to oxi- dative damage in streptozotocin treated mice: Prevention by extracts of Withania somnifera and Aloe vera. J. Clin. Neurosci. 2004; 11(4):397–402. https://doi.org/10.1016/j. jocn.2003.09.008. PMid:15080956

  • Yagi A, Hegazy S, Kabbash A, Wahab EAE. Possible hypo- glycemic effect of Aloe vera L. high molecular weight fractions on type 2 diabetic patients. Saudi Pharm. J. 2009; 17(3):209–15. https://doi.org/10.1016/j.jsps.2009.08.007. PMid:23964163. PMCid:PMC3731013

  • Kim K, Chung MH, Park S, Cha J, Baek JH, Lee SY, et al. ER Stress attenuation by Aloe‐derived polysaccha- rides in the protection of pancreatic beta‐cells from free fatty acid‐induced lipotoxicity. Biochem. Biophys. Res. Commun. 2018; 500(3):797–803. https://doi.org/10.1016/j. bbrc.2018.04.162. PMid:29684344

  • Misawa E, Tanaka M, Nomaguchi K, Yamada M, Toida T, Takase M, Kawada T. Administration of phytosterols isolated from Aloe vera gel reduce visceral fat mass and improve hyperglycemia in Zucker Diabetic Fatty (ZDF) rats. Obes. Res. Clin. Pract. 2008; 2(4):239–45. https://doi. org/10.1016/j.orcp.2008.06.002. PMid:24351850

  • Saito M, Tanaka M, Misawa E, Yamada M, Yamauchi K, Iwatsuki. Aloe vera gel extract attenuates ethanol‐induced hepatic lipid accumulation by suppressing the expression of lipogenic genes in mice. Biosci. Biotechnol. Biochem. 2012; 76(11):2049–54. https://doi.org/10.1271/bbb.120393. PMid:23132591

  • Alinejad‐Mofrad S, Foadoddini M, Saadatjoo SA, Shayesteh M. Improvement of glucose and lipid profile status with Aloe vera in prediabetic subjects: A randomized con- trolled‐trial. J. Diabetes Metab. Disord. 2015; 14:22. https:// doi.org/10.1186/s40200-015-0137-2. PMid:25883909. PMCid:PMC4399423

  • Yongchaiyudha S, Rungpitarangsi V, Bunyapraphatsara N, Chokechaijaroenporn O. Antidiabetic activity of Aloe vera L. juice. I. Clinical trial in new cases of diabetes mellitus. Phytomedicine. 1996; 3(3):241–3. https://doi.org/10.1016/ S0944-7113(96)80060-2

  • Choudhary M, Kochhar A, Sangha J. Hypoglycemic and hypolipidemic effect of Aloe vera L. in non-insulin dependent diabetics. J. Food Sci. Technol. 2014; 51(1):90–6. https://doi. org/10.1007/s13197-011-0459-0. PMid:24426052. PMCid: PMC3857397

  • Choi HC, Kim SJ, Son KY, Oh BJ, Cho BL. Metabolic effects of aloe vera gel complex in obese prediabetes and early nontreated diabetic patients: Randomized controlled trial. Nutrition (Burbank, Los Angeles County, Calif). 2013; 29(9):1110–14. https://doi.org/10.1016/j.nut.2013.02.015. PMid:23735317

  • Crawford P. Effectiveness of cinnamon for lowering hemo- globin A1c in patients with type 2 diabetes: A randomized, controlled trial. J. Am. Board Fam. Med. 2009; 22(5):507– 12. https://doi.org/10.3122/jabfm.2009.05.080093. PMid: 19734396

  • Khan A, Safdar M, Ali Khan MM, Khattak KN, Anderson RA. Cinnamon improves glucose and lipids of people with type 2 diabetes. Diabetes Care. 2003; 26(12):3215–18. https://doi.org/10.2337/diacare.26.12.3215. PMid:14633804

  • Anderson RA. Chromium and polyphenols from cin- namon improve insulin sensitivity. Proc. Nutr. Soc. 2008; 67(1):48–53. https://doi.org/10.1017/S0029665108006010. PMid:18234131

  • Ziegenfuss TN, Hofheins JE, Mendel RW, Landis J, Anderson RA. Effects of a water-soluble cinnamon extract on body composition and features of the metabolic syn- drome in pre-diabetic men and women. J. Int. Soc. Sports Nutr. 2006; 3:45–53. https://doi.org/10.1186/1550-2783-3- 2-45. PMid:18500972. PMCid:PMC2129164

  • Cefalu WT. Inflammation, insulin resistance, and type 2 diabetes: Back to the future? Diabetes. 2009; 58(2):307–8. https://doi.org/10.2337/db08-1656. PMid:19171748. PMCid:PMC2628602

  • Ribnicky DM, Poulev A, O’Neal J, Wnorowski G, Malek DE, Jager R, et al. Toxicological evaluation of the ethanolic extract of Artemisia dracunculus L. for use as a dietary sup- plement and in functional foods. Food Chem. Toxicol. 2004; 42(4):585–98. https://doi.org/10.1016/j.fct.2003.11.002. PMid:15019182

  • Cefalu WT, Ye J, Wang ZQ. Efficacy of dietary supplementa- tion with botanicals on carbohydrate metabolism in humans. Endocr. Metab. Immune. Disord. Drug Targets. 2008;8:78–81. https://doi.org/10.2174/187153008784534376. PMid:18537692

  • Cousens G. There is a cure for diabetes: The tree of life 21 day program. California: North Atlantic Books; 2008. p. 191–2.

  • Wehash FE, Abpo-Ghanema II, Saleh RM. Some physi- ological effects of Momordica charantia and Trigonella foenum-graecum extracts in diabetic rats as compared with cidophage®. World Acad. Eng. Tech. 2012; 64:1206–14.

  • Fuangchana A, Sonthisombata P, Seubnukarnb T, Chanouanc R, Chotchaisuwatd P, Sirigulsatiene V, et al. Hypoglycemic effect of bitter melon compared with metformin in diag- nosed type 2 diabetes patients. J. Ethnopharmacol. 2011; 134:422–8 https://doi.org/10.1016/j.jep.2010.12.045. PMid:21211558

  • Ogbonnia SO, Odimegu JI, Enwuru VN. Evaluation of hypo- glycemic and hypolipidemic effects of ethanolic extracts of Treculia africana Decne and Bryopyllum pinnatum Lam. and their mixture on streptozotocin (STZ)- induced dia- betic rats. Afr. J. Biotech. 2008; 7(15):2535–9.

  • Lee SY, Eom SH, Kim YK, Park NI, Park SU. Cucurbitane- type triterpenoids in Momordica charantia Linn. J. Med. Plants Res. 2009; 3(13):1264–9.

  • Tsi C, Chen EC, Tsay H, Huang C. Wild bitter gourd improves metabolic syndrome: A preliminary dietary supplementation trial. Nutr. J. 2012; 11:4. https://doi.org/10.1186/1475-2891-11- 4. PMid:22243626. PMCid: PMC3311063

  • Hasan I, Khatoon S. Effect of Momordica charantia (bit- ter gourd) tablets in diabetes mellitus: Type 1 and Type 2. Prime Res. Med. (PROM). 2012; 2(2):72–4.

  • Wehash FE, Abpo-Ghanema II, Saleh RM. Some physi- ological effects of Momordica charantia and Trigonella foenum-graecum extracts in diabetic rats as compared with cidophage®. World Acad. Eng. Tech 2012; 64:1206–14.

  • Dans AM, Villarruz MV, Jimeno CA, Anthony M, Javelosab U, Chuaa J, et al. The effect of Momordica charantia cap- sule preparation on glycemic control in type 2 diabetes mellitus needs further studies. J. Clin. Epidemiol. 2007; 60:554–9. https://doi.org/10.1016/j.jclinepi.2006.07.009. PMid:17493509

  • Tongia A, Tongia SK, Dave M. Phytochemical determina- tion and extraction of Momordica charantia fruit and its hypoglycemic potentiation of oral hypoglycemic drugs in diabetes mellitus (NIDDM). Indian J. Physiol. Pharmacol. 2004; 48:241–4.

  • Ahmad N, Hassan MR, Halder H, Bennoor KS. Effect of Momordica charantia (Karolla) extracts on fasting and post- prandial serum glucose in NIDDM patients. Bangladesh Med. Res. Council Bull. 1999; 25:11–13.

  • Grover JK, Gupta SR. Hypoglycemic activity of seeds of Momordica charantia. Eur. J. Pharmacol.1990; 183:1026–7. https://doi.org/10.1016/0014-2999(90)92880-R

  • Welihinda J, Arvidson G, Gyfle E, Hellman B, Karlsson E. The insulin-releasing activity of the tropical plant Momordica charantia. Acta Biol. Med. Germ. 1982; 41:1229–40.

  • Akhtar MS. Trial of Momordica charantia Linn (Karela) powder in patients with maturity-onset diabetes. J. Pakistan Med. Assoc. 1982; 32:106–7.

  • Leatherdale BA, Panesar RK, Singh G, Atkins TW, Bailey CJ, Bignell AH. Improvement in glucose tolerance due to Momordica charantia (karela). Br. Med. J. 1981; 282:1823–4. https://doi.org/10.1136/bmj.282.6279.1823. PMid:6786635. PMCid:PMC1506397

  • Khanna P, Jain SC, Panagariya A, Dixt VP. Hypoglycaemic activity of polypeptide-p from a plant source. J. Nat. Prod. 1981; 44:648–55. https://doi.org/10.1021/np50018a002. PMid:7334382

  • Cummings E, Hundal HS, Wackerhage H, Hope M, Belle M, Adeghate E, et al. Momordica charantia fruit juice stimu- lates glucose and amino acid uptakes in L6 myotubes. Mol. Cell. Biochem. 2004; 261:99–1046. https://doi.org/10.1023/ B:MCBI.0000028743.75669.ab. PMid:15362491

  • Akhtar N, Khan BA, Majid A, Khan S, Mahmood T, Gulfishan, et al. Pharmaceutical and biopharmaceutical evaluation of extracts from different plant parts of indig- enous origin for their hypoglycemic responses in rabbits. Acta Pol. Pharm. 2011; 68(6):919–25.

  • Uebanso T, Arai H, Taketani Y, Fukaya M, Yamamoto H, Mizuno A, et al. Extracts of Momordica charantia supress postprandial hyperglycemia in rats. J. Nutr. Sci. Vitaminol (Tokyo). 2007; 53(6):482–6. https://doi.org/10.3177/ jnsv.53.482. PMid:18202535

  • Jeong J, Lee S, Hue J, Lee K, Nam SY, Yun YW, et al. Effect of bittermelon (Momordica charantia) on antidiabetic activity in C57BL/6J db/db mice. Korean J. Vet. Res. 2008; 48(3):327–36.

  • Abdollah M, Zuki ABZ, Goh YM, Rezaeizadeh A, Noordin MM. The effects of Momordica charantia on the liver in streptozotoc in induced diabetes in neonatal rats. Afr. J. Biotechnol. 2010; 9(31):5004–12.

  • Shibib BA, Khan LA, Rahman R. Hypoglycaemic activity enzymes glucose-6-phosphatase and fructose-1,6-bispho- sphatase and elevation of both liver and red-cell shunt enzyme glucose-6- phosphate dehydrogenase. Biochem. J. 1993; 292:267–70. https://doi.org/10.1042/bj2920267. PMid:8389127. PMCid:PMC1134299

  • Singh J, Cumming E, Manoharan G, Kalasz H, Adeghate E. Medicinal chemistry of the anti-diabetic effects of Momordica charantia: Active constituents and modes of actions. Open Med. Chem. J. 2011; 5: 70–7. https://doi. org/10.2174/1874104501105010070. PMid:21966327. PMCid:PMC3174519

  • Gadang V, Gilbert W, Hettiararchchy N, Horax R, Katwa L, Devareddy L. Dietary bitter melon seed increases per- oxisome proliferator-activated receptor-γ gene expression in adipose tissue, down-regulates the nuclear factor-κB expression, and alleviates the symptoms associated with metabolic syndrome. J. Med. Food. 2011; 14: 86–93. https:// doi.org/10.1089/jmf.2010.0010. PMid:21128828

  • Kim K, Kim HY. Bitter melon (Momordica charantia) extract suppresses cytokine induced activation of MAPK and NF-κB in pancreatic β-cells. Food Sci. Biotechnol. 2011; 20(2):531–5. https://doi.org/10.1007/s10068-011-0074-x

  • Srinivasan K. Fenugreek (Trigonella foenum-grae- cum): A review of health beneficial physiological effects. Food. Rev. Intl. 2006; 22(2):203–24. https://doi. org/10.1080/87559120600586315

  • Gopalpura PB, Jayanthi C, Dubey S. Effect of Trigonella foe- num-graecum seeds on the glycemic index of food: A clinical evaluation. Int. J. Diab. Dev. Countries. 2009; 27(2):41–5. https://doi.org/10.4103/0973-3930.37033

  • Kassaian N, Azadbakht L, Forghani B, Amini M. Effect of fenugreek seeds on blood glucose and lipid profiles in type 2 diabetic patients. Int. J. Vitam. Nutr. Res. 2009; 79(1):34–9. https://doi.org/10.1024/0300-9831.79.1.34. PMid:19839001

  • Gopalpura PB, Jayanthi C, Dubey S. Effect of Trigonella foe- num-graecum seeds on the glycemic index of food: A clinical evaluation. Int. J. Diab. Dev. Countries. 2009; 27(2):41–5. https://doi.org/10.4103/0973-3930.37033

  • Yousefi E. Fenugreek: A therapeutic complement for patientswithborderlinehyperlipidemia:Arandomised, double-blind, placebo-controlled, clinical trial [Internet]. Adv. Integr. Med. 2021 [cited 17 September 2021]. Available from: https://www.researchgate.net/publica- tion/312664275_Fenugreek_A_therapeutic_complement_ for_patients_with_borderline_hyperlipidemia_A_ran- domised_double-blind_placebo-controlled_clinical_trial

  • Johnson SA, Figueroa A, Navaei N, Wong A, Kalfon R, Ormsbee LT, et al. Daily blueberry consumption improves blood pressure and arterial stiffness in postmenopausal women with pre- and stage 1-hypertension: A random- ized, double-blind, placebo-controlled clinical trial. J. Acad. Nutr. Diet. 2015; 115:369–77. https://doi.org/10.1016/j. jand.2014.11.001. PMid:25578927

  • Stull AJ, Cash KC, Champagne CM, Gupta AK, Boston R, Beyl RA, et al. Blueberries improve endo- thelial function, but not blood pressure, in adults with metabolic syndrome: A randomized, double-blind, pla- cebo-controlled clinical trial. Nutrients. 2015; 7:4107–23. https://doi.org/10.3390/nu7064107. PMid:26024297. PMCid:PMC4488775

  • Riso P, Klimis-Zacas D, del Bo’ C, Martini D, Campolo J, Vendrame S, et al. Effect of a wild blueberry (Vaccinium angustifolium) drink intervention on markers of oxidative stress, inflammation and endothelial function in humans with cardiovascular risk factors. Eur. J. Nutr. 2013; 52:949–61. https://doi.org/10.1007/s00394-012-0402-9. PMid:22733001

  • Stull AJ, Cash KC, Johnson WD, Champagne CM, Cefalu WT. Bioactives in blueberries improve insulin sensitiv- ity in obese, insulin-resistant men and women. J. Nutr. 2010; 140:1764–8. https://doi.org/10.3945/jn.110.125336. PMid:20724487. PMCid:PMC3139238

  • Basu A, Du M, Leyva MJ, Sanchez K, Betts NM, Wu M, et al. Blueberries decrease cardiovascular risk factors in obese men and women with metabolic syndrome. J. Nutr. 2010; 140:1582–7. https://doi.org/10.3945/jn.110.124701. PMid:20660279. PMCid:PMC2924596

  • Karlsen A, Paur I, Bøhn SK, Sakhi AK, Borge GI, Serafini M, et al. Bilberry juice modulates plasma concentration of NF-kB related inflammatory markers in subjects at increased risk of CVD. Eur. J. Nutr. 2010; 49:345–55. https:// doi.org/10.1007/s00394-010-0092-0. PMid:20119859

  • Peng N, Clark JT, Prasain J, Kim H, White CR, Wyss JM. Antihypertensive and cognitive effects of grape poly- phenols in estrogen-depleted, female, spontaneously hypertensive rats. Am. J. Physiol. Regul Integr. Comp. Physiol. 2005; 289(3):R771–75. https://doi.org/10.1152/ajp- regu.00147.2005. PMid:16105821

  • Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F, Kappagoda T. Effect of grape seed extract on blood pres- sure in subjects with the metabolic syndrome. Metabolism. 2009; 58(12):1743–6. https://doi.org/10.1016/j. metabol.2009.05.030 PMid:19608210

  • Aldini G, Carini M, Piccoli A, Rossoni G, Facino RM. Procyanidins from grape seeds protect endothelial cells from peroxynitrite damage and enhance endothelium- dependent relaxation in human artery: New evidences for cardioprotection. Life Sci. 2003; 73(22):2883–98. https:// doi.org/10.1016/S0024-3205(03)00697-0

  • Quesada H, del Bas JM, Pajuelo D, Díaz S, Fernandez-Larrea J, Pinent M, et al. Grape seed proanthocyanidins correct dyslipidemia associated with a high-fat diet in rats and repress genes controlling lipogenesis and VLDL assembling in liver. Int J Obes (Lond). 2009; 33(9):1007–12. https://doi. org/10.1038/ijo.2009.136. PMid:19581912

  • Sivaprakasapillai B, Edirisinghe I, Randolph J, Steinberg F, Kappagoda T. Effect of grape seed extract on blood pressure in subjects with the metabolic syndrome. Metabolism. 2009; 58:1743–6. https://doi.org/10.1016/j.metabol.2009.05.030. PMid:19608210

  • Sano A, Uchida R, Saito M, Shioya N, Komori Y, Tho, Y, et al. Beneficial effects of grape seed extract on malondialdehyde- modified, LDL. J. Nutr. Sci. Vitaminol. 2007; 53:174–82. https://doi.org/10.3177/jnsv.53.174. PMid:17616006

  • Wilson PW, Anderson KM, Castelli WP. Twelve-year inci- dence of coronary heart disease in middle-aged adults during the era of hypertensive therapy: The Framingham offspring study. Am. J. Med. 1991; 90:11–16. https://doi. org/10.1016/0002-9343(91)90500-W

  • Bopanna KN, Balaraman R, Kannan J, Gadgil S. Antidiabetic and antihyperlipidemic effect of neem seed kernel powder on alloxan induced diabetic rabbits. Indian J. Pharmacol. 1997; 29(3):162–7.

  • Rojo LE, Gaspar PA, Silva H, Risco L, Arena P, Cubillos- Robles K, et al. Metabolic syndrome and obesity among users of second generation antipsychotics: A global challenge for modern psychopharmacology. Pharmacol. Res. 2015; 101:74–85. https://doi.org/10.1016/j.phrs.2015.07.022. PMid:26218604

  • Albaugh VL, et al. Hormonal and metabolic effects of olanzapine and clozapine related to body weight in rodents. Obesity (Silver Spring). 2006; 14:36–51. https://doi.org/10.1038/oby.2006.6. PMid:16493121. PMCid:PMC2761763

  • Kaur G, Kulkarni SK. Studies on modulation of feeding behavior by atypical antipsychotics in female mice. Prog. Neuropsycho pharmacol. Biol. Psychiatry. 2002; 26:277–85. https://doi.org/10.1016/S0278-5846(01)00266-4

  • Vancampfort D, Correll CU, Galling B, Probst M, De Hert M, Ward PB, et al. Diabetes mellitus in people with schizo- phrenia, bipolar disorder and major depressive disorder: A systematic review and large scale meta-analysis. World Psychiatry. 2016; 15(2):166–74. https://doi.org/10.1002/ wps.20309. PMid:27265707. PMCid:PMC4911762

  • Cohen D, Batstra MR, Gispen-de Wied CC. Immunological characteristics of diabetes in schizophrenia. Diabetologia.2005; 48(9):1941–2. https://doi.org/10.1007/s00125-005-1879-z. PMid:16052326

  • Stahl S, Mignon L, Meyer J. Which comes first: A typi-

  • cal antipsychotic treatment or cardiometabolic risk? Acta Psychiatr. Scand. 2009; 119:171–9. https://doi.org/10.1111/ j.1600-0447.2008.01334.x. PMid:19178394

  • Kabinoff GS, Toalson PA, Healey KM, McGuire HC, Hay DP. Metabolic issues with atypical antipsychotics in pri- mary care: dispelling the myths. Prim. Care Companion. J. Clin. Psychiatry. 2003; 5–14. https://doi.org/10.4088/PCC. v05n0103. PMid:15156241. PMCid:PMC353028

  • Xiang SY, Zhao J, Lu Y, Chen RM, Wang Y, Chen Y, et al. Network pharmacology-based identification for therapeutic mechanism of Ling-Gui-Zhu-Gan decoction in the meta- bolic syndrome induced by antipsychotic drugs. Comput. Biol. Med. 2019 Jul; 110:1–7. https://doi.org/10.1016/j. compbiomed.2019.05.007. PMid:31085379

  • Suresh V, Lakhani JD, Shah R, Kataria L, Balaraman R. The prevalence of metabolic syndrome of patients on treatment with haloperidol and risperidone or olanzapine. J. Pharm. Res. Int. 2021; 33(44A):320–7. https://doi.org/10.9734/ jpri/2021/v33i44A32618

  • Sareddy P, Pandya HB, Sumple RS, Lakhani JD. Diabetic CAD versus non diabetic CAD: A comparative study of clini- cal features, risk factors and angiographic profile. Int. J. Adv. Med. 2021; 8(7):927–33. https://doi.org/10.18203/2349- 3933.ijam20212403

  • Pandya H, Lakhani JD, Patel N. Obesity is becoming syn- onym for diabetes in rural areas of India also an alarming situation, Int. J. Biol. Med. Res. 2011; 2(2):556–60


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  • A Review on the Possible Therapeutic Intervention by Herbal Remedies on Antipsychotic Drugs Induced Metabolic Disorder

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Authors

Velumani Suresh
Sumandeep Nursing College, Sumandeep Vidyapeeth Deemed to be University, Pipariya, Vadodara - 391760, India
J. D Lakhani
Department of General Medicine, S.B.K.S. MI & RC, Sumandeep Vidyapeeth Deemed to be University, Pipariya, Vadodara - 391760, India
Ramachandran Balaraman
Department of Pharmacy, Sumandeep Vidyapeeth Deemed to be University, Pipariya, Vadodara - 391760, India

Abstract


This review is the compilation of some of the natural products which are effective in treating diabetes, lipid abnormalities and cardiovascular diseases. We also discussed metabolic disorder associated with antipsychotic drugs. Currently, there are no equivocal evidence to demonstrate the effectiveness of herbal drugs in treating metabolic disorders induced by antipsychotic drugs. Therefore, there is a need of extensive research work to be carried out to explore the possibilities of therapeutic intervention of herbal drugs in antipsychotics induced metabolic disorders.


Keywords


Antipsychotic Drugs, Disorder, Herbal Drugs, Metabolism

References





DOI: https://doi.org/10.18311/jnr%2F2022%2F28665