Preliminary Analysis of the Antidiabetic Activity of Indonesian Polyherbal Formulation

This study aims to prepare polyherbal formulations and also analyze the antidiabetic potentials of the prepared polyherbal in animals. The ethanol extracts of the leaves of Smallanthus sonchifolius, Stevia rebaudiana, Syzygium polyanthum, and Camellia sinensis were used in this study. The extracts of the aforementioned plants were prepared in the ratio of 2:1:1:1. The formulation was tested for antidiabetic activity in vitro through the inhibition of alpha-glucosidase and in vivo using alloxan-induced diabetes in mice. The polyherbal has an inhibitory effect with the IC₅₀ value of 26.23 μg/mL compared to acarbose (control) was 17.02 μg/mL. The diabetic animals were observed to show an obvious decline in glucose level when compared with control (P< 0.001) after treatment.