Porang Glucomannan Supplementation Improves Lipid Profile in Metabolic Syndrome Induced Rats

Background: Porang glucomanan has been shown to have a potential properties for the prevention of Metabolic Syndrome (MetS). This study aimed to confirm that porang glucomannan supplementation can improve lipid profile in metabolic syndrome induced rats. Methods: Thirty male Sprague-Dawley rats were randomly divided into 5 groups consisting a contol group standard diet (Normal); Metabolic Syndrome group (SM), metabolic syndrome group+25 mg/200 gBW Porang Glucomannan (GMP25), metabolic syndrome group+50 mg/200 gBW Porang Glucomannan (GMP50), and metabolic syndrome group+100 mg/200 gBW Porang Glucomannan (GMP100). The lipid profile before and after induction with high-fat and high-carbohydrate diet, and after 28 days of porang treatment were evaluated. Data were analyzed using One Way Anova followed by LSD post hoc test. Results: GMP100 rats showed the highest reversal of diet-induced changes, with decreased total cholesterol (TC), triglycerides (TG), and LDL, and also increased HDL level. The mean levels of TC, TG, and LDL in GMP100, GMP50 and GMP25 was significantly lower than those of in MS (p=0.000), and was significantly higher than those of normal (p=0.000). While the levels of HDL in GMP 100, GMP50, and GMP25 was significantly higher than those of MS (p=0.000), but significantly lower than those of normal (p = 0.000). Conclusion: Porang glucomannan supplementation improve lipid profile in metabolic syndrome diet rats, with best dose at 100 mg/200 gBW.