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Amelioration of Trichosanthes lobata in Paracetamol-Induced Hepatic Damage in Rats:A Biochemical and Histopathological Evaluation


Affiliations
1 Department of Pharmacognosy, KLE University’s College of Pharmacy, Belagavi - 590010, Karnataka, India
 

The aim of the present work is to investigate the possible therapeutic potential of Trichosanthes lobata in paracetamol induced hepatic damage in rats. The hepatotoxicity was induced in rats by administration of paracetamol at higher dose (2 gm/kg) reflected in term of increase lipid peroxidation, impairment in antioxidants [Superoxide Dismutase (SOD), Catalase (CAT) and Reduced Glutathione (GSH)] along with elevation of serum marker enzymes. The possible ameliorative effect of Trichosanthes lobata Leaf extracts mainly Aqueous (TLAQ) and Alcoholic (TLAL) were administered at various doses for 7days and found to restored the depleted antioxidants (SOD, GSH, CAT) attenuated lipid peroxidation (MDA formation) and prevented elevated marker enzymes significantly. Further, histopathological alterations were also improved with TLAQ and TLAL in dose dependent manner. Thus, the hepatoprotective activity of TLAQ and TLAL may be correlated with amelioration of oxidative stress by improving endogenous antioxidant defence ability of hepatocytes and histopathological alterations in rats. The ameliorative effect of Trichosanthes lobata in paracetamol-induced hepatic damage in rats was studied.

Keywords

Flavonoids, Hepatic Damage, Paracetamol, Trichosanthes lobata.
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  • Amelioration of Trichosanthes lobata in Paracetamol-Induced Hepatic Damage in Rats:A Biochemical and Histopathological Evaluation

Abstract Views: 340  |  PDF Views: 157

Authors

Patil Kalpana
Department of Pharmacognosy, KLE University’s College of Pharmacy, Belagavi - 590010, Karnataka, India
Wadekar Raju
Department of Pharmacognosy, KLE University’s College of Pharmacy, Belagavi - 590010, Karnataka, India

Abstract


The aim of the present work is to investigate the possible therapeutic potential of Trichosanthes lobata in paracetamol induced hepatic damage in rats. The hepatotoxicity was induced in rats by administration of paracetamol at higher dose (2 gm/kg) reflected in term of increase lipid peroxidation, impairment in antioxidants [Superoxide Dismutase (SOD), Catalase (CAT) and Reduced Glutathione (GSH)] along with elevation of serum marker enzymes. The possible ameliorative effect of Trichosanthes lobata Leaf extracts mainly Aqueous (TLAQ) and Alcoholic (TLAL) were administered at various doses for 7days and found to restored the depleted antioxidants (SOD, GSH, CAT) attenuated lipid peroxidation (MDA formation) and prevented elevated marker enzymes significantly. Further, histopathological alterations were also improved with TLAQ and TLAL in dose dependent manner. Thus, the hepatoprotective activity of TLAQ and TLAL may be correlated with amelioration of oxidative stress by improving endogenous antioxidant defence ability of hepatocytes and histopathological alterations in rats. The ameliorative effect of Trichosanthes lobata in paracetamol-induced hepatic damage in rats was studied.

Keywords


Flavonoids, Hepatic Damage, Paracetamol, Trichosanthes lobata.

References