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Toxic Effects of Lead Chromate on the Liver of Swiss Albino Mice


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1 Department of Zoology, Patna women's College, PU. Patna-800005.
     

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An oral exposure of mice to Lead Chromate, 75 mg/kg bw/day in a single dose for 15 days changed the normal features of liver to a diseased one. Light and Electron microscopic studies have revealed significant change in treated animals compared to control. It appears that an alteration of the normal features of liver to diseased form by an oral exposure to Lead Chromate possibly could be a reason for liver cell damage.

Keywords

Lead Chromate, Liver, Light Microscope, Electron Microscope, Cell Damage
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  • Bhattacharya, S. and Mukherjee, S., 1975. Toxic effects of eldrin on hepatopancreas of teleosts fish. Indian J. Exp. Biol. 13: 185-186.
  • Cardenas, A., Roels, H., Bernard, A.M., Barbon, R., Buchet, J.P., Lauwerys, R.R., Rosselo, J., Ramis, I., Mutti, A., Franchini, I., Fels, L.M., Stolte, H., de Broe, M.E., Nuyts, G.D., Taylor, S.A., Price, R.G. 1993. Markers of early renal changes induced by industrial pollutants. J. Ind. Med. 50: 28-36.
  • Choie, D.D. and Richter, G.W. 1974. Cell proliferation in mouse kidney induced by lead. Lab invest. 30: 647-651 Arch. Environ. Health.
  • Christensen, G.M. 1977. The effects of methylmercuric chloride, cadmium chloride and lead nitrate on six bio-chemical factors of the brook trout. Toxicol, appl. Pharmacol. 42: 523-530.
  • Cramer, K., Goyer, R.A., Jajenburg, O.R., Wilson, M.H. 1994. Renal ultrastructure, renal function and parameters of lead toxicity in workers with different length if lead exposure. J. Ind. Med. 31: 113-127.
  • Cullen, M.R., Kayne, R.D., Robins, J.M. 1984. Endocrine and reproductive dysfunction in men associated with occupational inorganic lead intoxication. 39: 431-440.
  • Dutta, H.M., Adhikari, S., Singh, N.K.,Roy, P.K., and Munsi, J.S.D., 1993. Histopathological changes in the liver of a fresh water fish. Bull. Environ. Contam.Toxicol. 51:895-900.
  • El-Elaimy, I.A., Sakr, S.A., El-Sadeny, M.M., and Gabr, S.A., 1993. Electron microscopic studies of the liver of Tilapia exposed to neopybuthrin. Bull. Environ. Contam. 50: 682-688.
  • Goyer, R.A., Weinberg, C.R., Victory, W.M., Miller, C.R. 1989. Lead induced nephrotoxicity. Phenum Press. 11-20.
  • Goyer, R.A. 1992. Nephrotoxicity and Carcinogenicity of Lead – An update on exposure and effects of Lead. Fundamental Appl. Toxicol. 18: 1-16.
  • Graziano, J.H., Slavkovic, V., Factor-Litvak, P., Popovac, C.D. 1991. Depressed Serum erythropoietin in pregnant women with elevated blood lead. Arch.Environ Health.46: 349-350.
  • Gupta, M., Mukherjee, S., Gupta, S.D., Dolu, A.K.,Dey, S.N. and Roy, D.K., 1986. Changes of lipid spectrum in different tissues of furadan treated mice. Toxicol. 38: 69-79.
  • Gupta, Y.K., and Saxena, P.N., 2000. Assessment of liver lipid profile of Passer domesticus Indian J. Toxicol. 7: 103-108.
  • Hoffman, D.J., Franson, J.C., Pattee, O.H., Bunck, C.M., Murray, H.C. 1985b. Biochemical and Haematological effects of lead ingestion in nestling. Comp. Biochem. Physiol. 80: 431-439.
  • Johansson Sjobeck, M.L. and Larsson, A. 1979. Effects of inorganic lead on delta-aminolevulinic acid dehydratase activity and haematological variables in the rainbow trout. Arca. Environ. Contam. Toxicol. 8: 419-431.
  • Kazantzis, G. 1989. Lead: ancient metal-modern menace. Kluwer Academic Press. 119-128.
  • Kumar, S., and Singh, M., 2000. Toxicity of dimethoate to a fresh water fish Catla. J.Exp. 3(1): 812-813. Acta. Pharmacol.
  • Lerda, D. 1992. Study of sperm characteristics in persons occupationally exposed to lead. Am. J. Ind. Med. 22: 567-571.
  • Magnusson, G., 1963. The behavior of certain lanthanum in rats. 20.Supp.3
  • Mathur, D.S., 1965. "Histopathological changes in the liver cells induced by dieldrin".Sc.cult. 31: 285-289.
  • Moore, M.R. and Meredith, P.A. 1979. The Carcinogenicity of lead. Arch. Toxicol. 42: 87-94.
  • Niktin, Y.U.P., Kurilwich, S.A., and Devidek, G.S., 1985. Liver and lipid metabolism. Ruussian Nauka Navosibirsk. 8: 7-144.
  • Weeden, R.P., Mallik, D.K., Batumen, V. 1979. Detection and treatment of occupational lead nephropathy. Arch. Inter. Med. 139: 53-58.

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  • Toxic Effects of Lead Chromate on the Liver of Swiss Albino Mice

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Authors

Reshma Sinha
Department of Zoology, Patna women's College, PU. Patna-800005.
Doris D'souza
Department of Zoology, Patna women's College, PU. Patna-800005.

Abstract


An oral exposure of mice to Lead Chromate, 75 mg/kg bw/day in a single dose for 15 days changed the normal features of liver to a diseased one. Light and Electron microscopic studies have revealed significant change in treated animals compared to control. It appears that an alteration of the normal features of liver to diseased form by an oral exposure to Lead Chromate possibly could be a reason for liver cell damage.

Keywords


Lead Chromate, Liver, Light Microscope, Electron Microscope, Cell Damage

References