Indian Journal of Science and Technology

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Nanocomposites Based on Polymer and Hydroxyapatite for Drug Delivery Application


Affiliations
1 Biomedical Engineering, Bharath University, Chennai - 600 073, India
2 R & D Engineer, URILAB Systems-Diagnostics, New Delhi- 110 081
3 Department of ECE, PSNACET, Dindigul – 624 622
4 SMK Fomra Institute of Technology, Chennai – 600 103
 

This research paper tells about sustained delivery of small molecular drug ciprofloxacin using hydroxyapatite hybrid poly (vinyl alcohol) nanocomposites. Hydroxyapatite - poly (vinyl alcohol) nanocomposites are used as a vehicle to carry drug, protein, implantable materials etc. In situ synthesized hydroxyapatite hybrid poly (vinyl alcohol) matrix was characterized using different characterization techniques like XRD, SEM and FTIR. Small molecular drug ciprofloxacin was loaded into hydroxyapatite hybrid poly (vinyl alcohol) nanocomposites. The morphology of drug free and drug loaded hydroxyapatite concoction poly (vinyl alcohol) nanocomposites is observed using SEM. In-vitro drug release is quantified using UV/VIS spectrophotometer.

Keywords

Hydroxyapatite (HAP), Poly (Vinyl Alcohol) (PVA), Ciprofloxacin, Nanocomposites, Sustained Release, Drug Delivery, X-ray Diffraction (XRD), Scanning Electron Microscope (SEM)
User

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  • Nanocomposites Based on Polymer and Hydroxyapatite for Drug Delivery Application

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Authors

M. Sundar Raj
Biomedical Engineering, Bharath University, Chennai - 600 073, India
V. H. Arkin
R & D Engineer, URILAB Systems-Diagnostics, New Delhi- 110 081
Adalarasu
Department of ECE, PSNACET, Dindigul – 624 622
M. Jagannath
SMK Fomra Institute of Technology, Chennai – 600 103

Abstract


This research paper tells about sustained delivery of small molecular drug ciprofloxacin using hydroxyapatite hybrid poly (vinyl alcohol) nanocomposites. Hydroxyapatite - poly (vinyl alcohol) nanocomposites are used as a vehicle to carry drug, protein, implantable materials etc. In situ synthesized hydroxyapatite hybrid poly (vinyl alcohol) matrix was characterized using different characterization techniques like XRD, SEM and FTIR. Small molecular drug ciprofloxacin was loaded into hydroxyapatite hybrid poly (vinyl alcohol) nanocomposites. The morphology of drug free and drug loaded hydroxyapatite concoction poly (vinyl alcohol) nanocomposites is observed using SEM. In-vitro drug release is quantified using UV/VIS spectrophotometer.

Keywords


Hydroxyapatite (HAP), Poly (Vinyl Alcohol) (PVA), Ciprofloxacin, Nanocomposites, Sustained Release, Drug Delivery, X-ray Diffraction (XRD), Scanning Electron Microscope (SEM)

References





DOI: https://doi.org/10.17485/ijst%2F2013%2Fv6iS5%2F33369