Indian Journal of Science and Technology

Open Access Open Access  Restricted Access Subscription Access

Influence of Parental Consanguinity on the Prevalence of Coronary Artery Disease in the Progeny


Affiliations
1 Department of Cardiology, KLE University's J.N. Medical College, Belgaum-590010, Karnataka, India
 

Over the last decade, cardiovascular disease especially coronary heart disease has become the largest cause of death worldwide. This study was taken to determine the effects of parental consanguinity on the coronary artery disease (CAD) risk in the progeny. Over a period of one year from April 2010 to March 2011, 1000 patients of CAD who underwent cardiac catheterization were included in the study. Among these patients the presence of parental consanguinity and family history of CAD was noted and their impact on CAD risk was determined, controlling for diabetes mellitus, hyperlipidemia, hypertension and smoking. Parental consanguinity was present in 1.5 % (15 patients) of the total CAD patients studied. 1% (10 patients) had both parental consanguinity and family history of CAD. While consanguinity did not promote risk of CAD, but along with family history of CAD it did affect age of disease diagnosis. When both consanguinity and family history of CAD were considered as risk factors for CAD, the mean age of at CAD diagnosis was 51.2 years, compared to 62.2 years for the no-risk factor patient category. Parental consanguinity and family history of CAD is an additional risk factor and lowers the age of diagnosis for CAD. Given the extremely high prevalence of premature CAD in South Asian population, an investigation of recessive genes as predisposing factors for CAD would appear to be warranted.

Keywords

Coronary Heart Disease, Consanguinity
User

  • Abu-Amero KK, Al-Boudari OM, Mohamed GH, et al. (2006) The Glu27 genotypes of the beta2-adrenergic receptor are predictors for severe coronary artery disease. BMC Med. Genet.7, 31.

  • Bittles AH and Black ML (2010) Evolution in health and medicine sackler colloquium: consanguinity, human evolution, and complex diseases. Proc. Natl. Acad. Sci. USA.107 (Suppl. 1),1779–1786.

  • Ghaffar A, Reddy KS and Singhi M (2004) Burden of non-communicable diseases in South Asia.BMJ. 328, 807.

  • Hartl DL and Clark AG (2007) Principles of population genetics. 4thed. Sunderland, MA: Sinauer Associates.

  • Nordlie MA, Wold LE and Kloner RA (2005) Genetic contributors toward increased risk for ischemic heart disease. J.Mol.Cell. Cardiol .39(4), 667–679.

  • Robert O Bonow, Douglas L Mann, FACC, Douglas P Zipes and Peter Libby (2012) Braunwalds’ heart disease: A textbook of cardiovascular medicine, 9th ed. Elsevier Saunders. pp: 1-2048.

  • Scheuner MT (2004) Clinical application of genetic risk assessment strategies for coronary artery disease: genotypes, phenotypes, and family history. Primary Care. 31(3), 711–737.

  • Scheuner MT, Wang SJ, Raffel LJ, et al. (1997) Family history: a comprehensive genetic risk assessment method for the chronic conditions of adulthood. Am. J. Med. Genet. 71(3), 315–324.

  • Youhanna S, Platt DE, Rebeiz A, Lauridsen M, Deeb ME, Nasrallah A, Alam S, Puzantian H, Kabbani S, Ghoul M, Zreik TG, Bayeh H, Abchee A and Zalloua P (2010) FGNETCARD consortium. Parental consanguinity and family history of coronary artery disease strongly predict early stenosis. Atherosclerosis. 212, 559–563.


Abstract Views: 396

PDF Views: 101




  • Influence of Parental Consanguinity on the Prevalence of Coronary Artery Disease in the Progeny

Abstract Views: 396  |  PDF Views: 101

Authors

Prashanth Kulkarni
Department of Cardiology, KLE University's J.N. Medical College, Belgaum-590010, Karnataka, India
Prabhu Halkati
Department of Cardiology, KLE University's J.N. Medical College, Belgaum-590010, Karnataka, India
Suresh Patted
Department of Cardiology, KLE University's J.N. Medical College, Belgaum-590010, Karnataka, India
Sameer Ambar
Department of Cardiology, KLE University's J.N. Medical College, Belgaum-590010, Karnataka, India
Ameet Sattur
Department of Cardiology, KLE University's J.N. Medical College, Belgaum-590010, Karnataka, India
S. T Yavagal
Department of Cardiology, KLE University's J.N. Medical College, Belgaum-590010, Karnataka, India

Abstract


Over the last decade, cardiovascular disease especially coronary heart disease has become the largest cause of death worldwide. This study was taken to determine the effects of parental consanguinity on the coronary artery disease (CAD) risk in the progeny. Over a period of one year from April 2010 to March 2011, 1000 patients of CAD who underwent cardiac catheterization were included in the study. Among these patients the presence of parental consanguinity and family history of CAD was noted and their impact on CAD risk was determined, controlling for diabetes mellitus, hyperlipidemia, hypertension and smoking. Parental consanguinity was present in 1.5 % (15 patients) of the total CAD patients studied. 1% (10 patients) had both parental consanguinity and family history of CAD. While consanguinity did not promote risk of CAD, but along with family history of CAD it did affect age of disease diagnosis. When both consanguinity and family history of CAD were considered as risk factors for CAD, the mean age of at CAD diagnosis was 51.2 years, compared to 62.2 years for the no-risk factor patient category. Parental consanguinity and family history of CAD is an additional risk factor and lowers the age of diagnosis for CAD. Given the extremely high prevalence of premature CAD in South Asian population, an investigation of recessive genes as predisposing factors for CAD would appear to be warranted.

Keywords


Coronary Heart Disease, Consanguinity

References





DOI: https://doi.org/10.17485/ijst%2F2012%2Fv5i5%2F30457