Indian Journal of Science and Technology

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Preparation and Swelling Behavior of Carrageenan-graft-polymethacrylamide Superabsorbent Hydrogel as a Releasing Drug System


Affiliations
1 Young researchers club, Islamic Azad University, Khorramabad Branch, Khorramabad, Iran, Islamic Republic of
2 Department of Chemistry, Science Faculty, Islamic Azad University, Arak Branch, Arak, Iran, Islamic Republic of
 

The polysaccharide, kappa-carrageenan (κC) was chemically modified to achieve a novel superabsorbent hydrogel via graft copolymerization of acrylamide (AAm) onto the substrate followed by alkaline hydrolysis. Ammonium persulfate (APS) and N,N'-methylene bisacrylamide (MBA) were used as a free-radical initiator and a crosslinker, respectively. The saponification reaction was carried out using sodium hydroxide aqueous solution. Either κC-g-PAAm or hydrolyzed κC-g-PAcA was characterized by FTIR spectroscopy. The effect of media variables such as alkaline hydrolysis conditions (i.e., NaOH concentration, hydrolysis time and temperature) were systematically optimized to achieve a hydrogel with swelling capacity as high as possible. Absorbency of superabsorbing hydrogels was examined in buffer solutions with pH ranged 1-13. Also, the pH reversibility and on-off switching behavior, at pH 2.0 and 9.0, makes the synthesized hydrogels as a good candidate for controlled delivery of bioactive agents. Finally, the κC-g-PAcA hydrogel exhibited a pH-responsiveness character so that a swelling-deswelling pulsatile behavior was recorded at pH 1.2 and 7.4. In addition, the delivery behavior of Acetaminophen from the hydrogel bead was studied.

Keywords

Carrageenan, Hydrogel, Superabsorbent, pH-sensitive, Acetaminophen
User

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  • Preparation and Swelling Behavior of Carrageenan-graft-polymethacrylamide Superabsorbent Hydrogel as a Releasing Drug System

Abstract Views: 564  |  PDF Views: 156

Authors

Fatemeh Soleimani
Young researchers club, Islamic Azad University, Khorramabad Branch, Khorramabad, Iran, Islamic Republic of
Mohammad Sadeghi
Department of Chemistry, Science Faculty, Islamic Azad University, Arak Branch, Arak, Iran, Islamic Republic of
Hadis Shahsavari
Young researchers club, Islamic Azad University, Khorramabad Branch, Khorramabad, Iran, Islamic Republic of

Abstract


The polysaccharide, kappa-carrageenan (κC) was chemically modified to achieve a novel superabsorbent hydrogel via graft copolymerization of acrylamide (AAm) onto the substrate followed by alkaline hydrolysis. Ammonium persulfate (APS) and N,N'-methylene bisacrylamide (MBA) were used as a free-radical initiator and a crosslinker, respectively. The saponification reaction was carried out using sodium hydroxide aqueous solution. Either κC-g-PAAm or hydrolyzed κC-g-PAcA was characterized by FTIR spectroscopy. The effect of media variables such as alkaline hydrolysis conditions (i.e., NaOH concentration, hydrolysis time and temperature) were systematically optimized to achieve a hydrogel with swelling capacity as high as possible. Absorbency of superabsorbing hydrogels was examined in buffer solutions with pH ranged 1-13. Also, the pH reversibility and on-off switching behavior, at pH 2.0 and 9.0, makes the synthesized hydrogels as a good candidate for controlled delivery of bioactive agents. Finally, the κC-g-PAcA hydrogel exhibited a pH-responsiveness character so that a swelling-deswelling pulsatile behavior was recorded at pH 1.2 and 7.4. In addition, the delivery behavior of Acetaminophen from the hydrogel bead was studied.

Keywords


Carrageenan, Hydrogel, Superabsorbent, pH-sensitive, Acetaminophen

References





DOI: https://doi.org/10.17485/ijst%2F2012%2Fv5i2%2F30355