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Studies on Adsorption of Diphtheria Toxoid on Aluminium Phosphate Gel


Affiliations
1 Pasteur Institute of India, Coonoor, Nilgiris-643 103 Tamilnadu, India
 

Aluminium compounds are widely used as an adjuvant in Diphtheria, Tetanus, and Pertussis (DPT) group of vaccines. Diphtheria and tetanus toxoids are adsorbed on aluminium phosphate gel and used in the immunization. Generally a plain vaccine is less immunogenic. After adsorption it will have a repositary action. The present study envisages the adsorption rate of diphtheria toxoid on aluminium phosphate gel at different pH (5.0, 6.0, 6.5, 7.0 and 7.5). The main conclusion drawn from the experiments is that the low pH favours high adsorption rate.

Keywords

Diphtheria Toxoid, Aluminium Phosphate Gel, Adsorption, Vaccine
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  • Studies on Adsorption of Diphtheria Toxoid on Aluminium Phosphate Gel

Abstract Views: 621  |  PDF Views: 129

Authors

N. Sivananda
Pasteur Institute of India, Coonoor, Nilgiris-643 103 Tamilnadu, India
B. Sundaran
Pasteur Institute of India, Coonoor, Nilgiris-643 103 Tamilnadu, India

Abstract


Aluminium compounds are widely used as an adjuvant in Diphtheria, Tetanus, and Pertussis (DPT) group of vaccines. Diphtheria and tetanus toxoids are adsorbed on aluminium phosphate gel and used in the immunization. Generally a plain vaccine is less immunogenic. After adsorption it will have a repositary action. The present study envisages the adsorption rate of diphtheria toxoid on aluminium phosphate gel at different pH (5.0, 6.0, 6.5, 7.0 and 7.5). The main conclusion drawn from the experiments is that the low pH favours high adsorption rate.

Keywords


Diphtheria Toxoid, Aluminium Phosphate Gel, Adsorption, Vaccine

References





DOI: https://doi.org/10.17485/ijst%2F2010%2Fv3i3%2F29691