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Synthesis and Characterization of Halocobaloximes and its Derivatives for Antimicrobial Activity


Affiliations
1 Department of Chemistry, Loyola College (Autonomous), Chennai-600 034, India
 

Cobaloximes of the types Trans- BH2[Co(dmgH)2X], where dmgH- = Dimethylglyoximate, X- = Cl- or Br- and Trans-[Co(dmgH)2(H2O)I].B where, B = Piperazine (Pp) or 2-(N-Tert-butylamido)piperazine (t- Bu-PpAM) were prepared and characterized by TG/DTA, FABMS UV-visible, IR, NMR spectra and XRD studies. All the cobaloximes were screened against microorganisms for their antimicrobial activity and compared with streptomycin as standard. The free ligands viz., Pp&t- Bu-PpAM, showed antimicrobial activity in the order: Pp < t-Bu-PpAM. Most of the cobaloximes were found to be more active than the corresponding ligands such that the antimicrobial activity order for the axial halides was found to be Cl- > Br- > I - for cobaloximes having piperazine where as in the case of cobaloximes having 2-(N-Tertbutylamido) piperazine the antimicrobial activity order was found to be reversed as Br - > Cl- >I- .

Keywords

Cobalt(III) Complexes, Cobaloximes, Antimicrobial Activity of Cobalt (III) Complexes
User

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  • Synthesis and Characterization of Halocobaloximes and its Derivatives for Antimicrobial Activity

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Authors

S. Martin
Department of Chemistry, Loyola College (Autonomous), Chennai-600 034, India
A. Dayalan
Department of Chemistry, Loyola College (Autonomous), Chennai-600 034, India

Abstract


Cobaloximes of the types Trans- BH2[Co(dmgH)2X], where dmgH- = Dimethylglyoximate, X- = Cl- or Br- and Trans-[Co(dmgH)2(H2O)I].B where, B = Piperazine (Pp) or 2-(N-Tert-butylamido)piperazine (t- Bu-PpAM) were prepared and characterized by TG/DTA, FABMS UV-visible, IR, NMR spectra and XRD studies. All the cobaloximes were screened against microorganisms for their antimicrobial activity and compared with streptomycin as standard. The free ligands viz., Pp&t- Bu-PpAM, showed antimicrobial activity in the order: Pp < t-Bu-PpAM. Most of the cobaloximes were found to be more active than the corresponding ligands such that the antimicrobial activity order for the axial halides was found to be Cl- > Br- > I - for cobaloximes having piperazine where as in the case of cobaloximes having 2-(N-Tertbutylamido) piperazine the antimicrobial activity order was found to be reversed as Br - > Cl- >I- .

Keywords


Cobalt(III) Complexes, Cobaloximes, Antimicrobial Activity of Cobalt (III) Complexes

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DOI: https://doi.org/10.17485/ijst%2F2009%2Fv2i9%2F29523