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Studies on Antivenom Activity of Andrographis paniculata and Aristolochia indica Plant Extracts against Daboia russelli Venom by in Vivo and in Vitro Methods


Affiliations
1 Dept. of Microbiol., Nehru Arts & Science College, India
2 PSG College of Arts and Science, Coimbatore, India
 

Methanolic extracts of Andrographis paniculata and Aristolochia indica plants were tested for antivenom activity against Daboia russelli venom. Both plant extracts effectively neutralized the D. russelli venom induced lethal activity. About 0.15 mg of A. paniculata and 0.14 mg of A. indica plant extracts were able to completely neutralize the lethal activity of 2LD50 of D. russelli venom. Various pharmacological activities including edema, haemorrhagic, coagulant, fibrinolytic and phospholipase activities were studied and these pharmacological activities were significantly neutralized by both the plant extracts. The above observations confirmed that A. paniculata and A. indica plant extracts possess potent snake venom neutralizing capacity and could potentially be used for therapeutic purposes in case of snakebite envenomation.

Keywords

Antivenom, Plant Extracts, Snake Bite
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  • Studies on Antivenom Activity of Andrographis paniculata and Aristolochia indica Plant Extracts against Daboia russelli Venom by in Vivo and in Vitro Methods

Abstract Views: 713  |  PDF Views: 281

Authors

S. Meenatchisundaram
Dept. of Microbiol., Nehru Arts & Science College, India
G. Parameswari
PSG College of Arts and Science, Coimbatore, India
A. Michael
PSG College of Arts and Science, Coimbatore, India

Abstract


Methanolic extracts of Andrographis paniculata and Aristolochia indica plants were tested for antivenom activity against Daboia russelli venom. Both plant extracts effectively neutralized the D. russelli venom induced lethal activity. About 0.15 mg of A. paniculata and 0.14 mg of A. indica plant extracts were able to completely neutralize the lethal activity of 2LD50 of D. russelli venom. Various pharmacological activities including edema, haemorrhagic, coagulant, fibrinolytic and phospholipase activities were studied and these pharmacological activities were significantly neutralized by both the plant extracts. The above observations confirmed that A. paniculata and A. indica plant extracts possess potent snake venom neutralizing capacity and could potentially be used for therapeutic purposes in case of snakebite envenomation.

Keywords


Antivenom, Plant Extracts, Snake Bite

References





DOI: https://doi.org/10.17485/ijst%2F2009%2Fv2i4%2F29436