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Search for Antihyperglycemic Activity in few Marine Flora and Fauna


Affiliations
1 Divisions of Biochemistry, ,Central Drug Research Institute, Lucknow-226001, India
2 Medicinal and Process Development Chemistry, Central Drug Research Institute, Lucknow-226001, India
3 Botany, Central Drug Research Institute, Lucknow-226001, India
4 Pharmacology, Central Drug Research Institute, Lucknow-226001, India
 

Evaluation and identification of some new natural molecules with antidiabetic property have become one of the major preludes of present day diabetic research. Although few marine natural products are currently in the market or in the clinical trials, marine organisms still remains the greatest unexploited source of potential pharmaceuticals. Because of the unusual diversity of chemical structures isolated from marine organisms, there is intense interest in screening marine natural products for their biomedical potential. Over 300 marine organisms including flora and fauna were collected at the Institute and extracted with methanol. Their extracts were evaluated for blood glucose lowering effect. The present study reports activity profile of 30marine flora/fauna evaluated in sucrose loaded rat model. Among the marine flora , extracts of Dolichandrone, Amoora cuculata, Chaetomorpha torta, Lumnitzera racemosa, Barringtonia racemosa and Excoecaria agallocha Microciona aceratoobtusa and mollusc Scapharca inaequivalvis at 250 mg/kg body weight dose showed slight but insignificant lowering in the blood glucose post sucrose load in normal rats, whereas, the extract of Cynometra ramiflora showed significant inhibition at the same dose . Among the marine fauna the extracts of soft coral Lobophytum pauciflorum, Sarcophyton glaucum and the extracts of sponge Sigmadocia pumila, showed a little but insignificant lowering in blood glucose post sucrose load in normal rats at 250 mg/kg body weight dose.

Keywords

Antihyperglycaemic Activity, Marine Flora, Marine Fauna, Oral Glucose Tolerance Test
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  • Alam N et al., (2001) Cytotoxic diacetylenes from the stony coral Montipora species. J. Nat. Prod. 64(8), 1059-1063.

  • Alam M et al., (1998) Isolation and structure of a cytotoxic epoxy sterol from the marine mollusc Planaxis sulcatus. Steroids. 52 (1-2), 45-50.

  • Azuma H et al., (2002) Floral scent chemistry of mangrove plants. J. Plant Res., 115 (1117), 47-53.

  • Badria F A et al., (1998) Sarcophytolide: a new neuroprotective compound from the soft coral Sarcophyton glaucum. Toxicology. 131 (2-3), 133-143.

  • Balaji Raghavendra Rao H et al., (2004) Antihepatotoxic nature of Ulva reticulate (Chlorophyceae) on acetaminophen induced hepatoxicity in experimental rats. J. Med. Food. 70(4), 495-497.

  • Brad K Carte (1996) Biomedical potential of Marine Natural Products. BioSciences. 46 (4), 271-286.

  • Deraniyagala S A et al., (2003) Antinociceptive effect and toxicological study of the aqueous bark extract of Barringtonia racemosa on rats. J. Ethanopharmacol. 86 (1), 21-26.

  • Edrada R A et al., (1998) Four new bioactives lobane diterpenes of the soft coral Lobophytum pauciflorum from Mindoro, Philippines. J. Nat. Prod. 61(3), 358-361.

  • Ghosh S et al., (2001) Effect of Vinca rosea extracts in treatment of alloxan diabetes in male albino rats. Ind. J. Exp. Biol. 39(8), 748- 759.

  • Khan S et al., (2001) Antibacterial activity of Barringtonia racemosa. Fitoterapia, 72 (2), 162-164.

  • Knott N A et al., (2006) Growth of the encrusting sponge Tedania anhelans (Lieberkuhn) on vertical and on horizontal surfaces of temperate subtidal reefs. Marine Freshwater Res. 57, 95-104.

  • Konishi T et al., (2003) Three diterpenoids (excoecarins VI-V3) and a flavone glycoside from the fresh stem of Excoecaria agallocha. Chem. Pharm. Bull. (Tokyo), 51(10), 1142- 1146.

  • Konoshima T et al., (2001) Antitumor promoting activity of the diterpene from Excoecaria agallocha. II. Biol. Pharm. Bul. 24(12), 1440-1442.

  • Kumaran R and Rajagopal S (1996) Antibacterial activity in the ink of sea hare Aplysia benedictii (Eliol). Poll.Res. 15 (3), 251- 252.

  • Muralidhar P et al., (1998) New sphingolipids and a sterol from a Lobophytum pauciflorum from Mindoro, Philippines. J. Nat. Prod. 61(3), 358-361.

  • Oku H et al., (2003) Lipid composition of mangrove and its relevance to salt tolerance. J. Plant Res. 116 (1), 37-45.

  • Premanathan M et al., (1999) Antiviral properties of a mangrove plant , Rhizophora apiculata Blime, against human immunodeficiency virus. Antiviral Res. 44 (2), 113-122.

  • Rabi T et al., (2003) Novel drug Amooranin induces apoptosis through caspase activity in human breast carcinoma cell lines. Breast Cancer Res. Treatment. 80 (3), 321-330.

  • Rao E V and Ramana K S (1991) Structural studies of a polysaccharide isolated from the green seaweed Chaetomorpha antennia. Carbohydr. Res. 217, 163-170.

  • Reddy A V et al., (2006) New anticancer bastadin alkaloids from the sponge Dendrilla cactos. Bioiog. Med. Chem. 14 (13), 4452- 4457.

  • Shaker K H et al., (2001) Iridoids from Avicennia marina. Z. Naturforsch., C:Biosci , 56 (11-12),965-958.

  • Sharaf M et al., (2000) New flavonoids from Avicennia marina. Fitoterapia. 71 (3), 274-277.

  • Shi D Y et al., (2005) Studies on chemical constitutes of green alga Chaetomorpha basiretorsa and their bioactivity. Zhongguo Zhong Yao Za Zhi. 30 (15), 1162-1165.

  • Srivastava R et al., (1991) Structure of pescaproside E, a fatty acid glycoside from Ipomoea pescaprae. Carbohydr. Res. 212, 169-176.

  • Thomas T J et al., (2002) Antitumor property and toxicity of Barringtonia racemosa Roxb seed extract in mice. J. Ethanopharmacol., 82 (2-3), 223-227.

  • Tiwari A K et al., (2002) Diabetes mellitus and multiple therapeutic approaches of phytochemicals: Present status and future prospects. Curr. Sci., 83 (1), 30-38.

  • Vijayavel K et al., (2006) Free radical scavenging activity of marine mangrove Rhizophora apiculata bark extract with reference to naphthalene induced mitochondrial dysfunction. Chem. Biol. Interact .June 23; ( Epub ahead of print ) PMID: 16860784.

  • Yang S M et al., (2006) Anticanceractivity of tirucallane triterpenoids from Amoora dasyclada. Z. Naturforsch., C: Biosci. 61 (3-4), 193-195.

  • Zou J H et al., (2006) Pentacyclic Triterpenoids from leaves of Excoecaria agallocha. Chem. Pharm. Bull . (Tokya), 54 (6), 920-921.


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  • Search for Antihyperglycemic Activity in few Marine Flora and Fauna

Abstract Views: 541  |  PDF Views: 134

Authors

Priti Tiwari
Divisions of Biochemistry, ,Central Drug Research Institute, Lucknow-226001, India
Neha Rahuja
Divisions of Biochemistry, ,Central Drug Research Institute, Lucknow-226001, India
Rajesh Kumar
Medicinal and Process Development Chemistry, Central Drug Research Institute, Lucknow-226001, India
Vijay Lakshmi
Medicinal and Process Development Chemistry, Central Drug Research Institute, Lucknow-226001, India
Mahendra Nath Srivastava
Botany, Central Drug Research Institute, Lucknow-226001, India
Suresh Chandra Agarwal
Botany, Central Drug Research Institute, Lucknow-226001, India
Ram Raghubir
Pharmacology, Central Drug Research Institute, Lucknow-226001, India
Arvind Kumar Srivastava
Divisions of Biochemistry, ,Central Drug Research Institute, Lucknow-226001, India

Abstract


Evaluation and identification of some new natural molecules with antidiabetic property have become one of the major preludes of present day diabetic research. Although few marine natural products are currently in the market or in the clinical trials, marine organisms still remains the greatest unexploited source of potential pharmaceuticals. Because of the unusual diversity of chemical structures isolated from marine organisms, there is intense interest in screening marine natural products for their biomedical potential. Over 300 marine organisms including flora and fauna were collected at the Institute and extracted with methanol. Their extracts were evaluated for blood glucose lowering effect. The present study reports activity profile of 30marine flora/fauna evaluated in sucrose loaded rat model. Among the marine flora , extracts of Dolichandrone, Amoora cuculata, Chaetomorpha torta, Lumnitzera racemosa, Barringtonia racemosa and Excoecaria agallocha Microciona aceratoobtusa and mollusc Scapharca inaequivalvis at 250 mg/kg body weight dose showed slight but insignificant lowering in the blood glucose post sucrose load in normal rats, whereas, the extract of Cynometra ramiflora showed significant inhibition at the same dose . Among the marine fauna the extracts of soft coral Lobophytum pauciflorum, Sarcophyton glaucum and the extracts of sponge Sigmadocia pumila, showed a little but insignificant lowering in blood glucose post sucrose load in normal rats at 250 mg/kg body weight dose.

Keywords


Antihyperglycaemic Activity, Marine Flora, Marine Fauna, Oral Glucose Tolerance Test

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DOI: https://doi.org/10.17485/ijst%2F2008%2Fv1i5%2F29349