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Mild Antihyperglycaemic Activity in Eclipta alba, Berberis aristata, Betula utilis, Cedrus deodara, Myristica fragrans and Terminalia chebula


Affiliations
1 Divisions of Biochemistry, Central Drug Research Institute, Lucknow-226001, India
2 Divisions of Biochemistry, Central Drug Research Institute, Lucknow-226001
3 Medicinal Chemistry, Central Drug Research Institute, Lucknow-226001, India
4 Botany, Central Drug Research Institute, Lucknow-226001, India
 

The ethanolic extracts of different parts of the following plants viz. Eclipta alba Hassk (Asteraceae) whole plant, ischolar_mains of Berberis aristata DC (Berbidaceae), stem wood of Betula utilis D. Don (Betulaceae), stem wood of Cedrus deodara (Pinaceae), and fruits of Myristica fragrans Houtt. (Myristcaceae) exhibited 7.5, 8.3, 9.2, 6.0, and 8.7% significant fall in blood glucose profile in a single dose experiment on Streptozotocin-induced diabetic rats. In single dose experiment nearly 8.0% decline in blood glucose profile of Streptozotocininduced diabetic rats was observed with a known antidiabetic ethanolic extract of the fruits of Terminalia chebula (Gaertn.) Retz. (Combretaceae).

Keywords

Antidiabetic Plants, Antihyperglycaemic Activity, Streptozotocin, Diabetes, Animal Models
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  • Mild Antihyperglycaemic Activity in Eclipta alba, Berberis aristata, Betula utilis, Cedrus deodara, Myristica fragrans and Terminalia chebula

Abstract Views: 717  |  PDF Views: 146

Authors

Rehan Ahmad
Divisions of Biochemistry, Central Drug Research Institute, Lucknow-226001, India
Swayam Prakash Srivastava
Divisions of Biochemistry, Central Drug Research Institute, Lucknow-226001
Rakesh Maurya
Medicinal Chemistry, Central Drug Research Institute, Lucknow-226001, India
S. M. Rajendran
Botany, Central Drug Research Institute, Lucknow-226001, India
K. R. Arya
Botany, Central Drug Research Institute, Lucknow-226001, India
Arvind K. Srivastava
Divisions of Biochemistry, Central Drug Research Institute, Lucknow-226001, India

Abstract


The ethanolic extracts of different parts of the following plants viz. Eclipta alba Hassk (Asteraceae) whole plant, ischolar_mains of Berberis aristata DC (Berbidaceae), stem wood of Betula utilis D. Don (Betulaceae), stem wood of Cedrus deodara (Pinaceae), and fruits of Myristica fragrans Houtt. (Myristcaceae) exhibited 7.5, 8.3, 9.2, 6.0, and 8.7% significant fall in blood glucose profile in a single dose experiment on Streptozotocin-induced diabetic rats. In single dose experiment nearly 8.0% decline in blood glucose profile of Streptozotocininduced diabetic rats was observed with a known antidiabetic ethanolic extract of the fruits of Terminalia chebula (Gaertn.) Retz. (Combretaceae).

Keywords


Antidiabetic Plants, Antihyperglycaemic Activity, Streptozotocin, Diabetes, Animal Models

References





DOI: https://doi.org/10.17485/ijst%2F2008%2Fv1i5%2F29348