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Non-Newtonian Behavior Effect on Gas-liquid Mass Transfer using an Anchor Impeller for CSTR Bioreactors:A CFD Approach


Affiliations
1 Department of Chemical Engineering, Universidad de Antioquia. Carrera 53 N.° 61-30. Medellín, Colombia
2 Department of Environment, Universidad Francisco de Paula Santander. Av. Gran Colombia 12E-96, Cúcuta, Colombia
 

Objectives: kLa mass transfer coefficient was predicted using CFD (computational fluid dynamics) for analyzing non-newtonian effects on gas liquid mass transfer in a 10 L bioreactor stirred with an Anchor Impeller. Methods/Statistical Analysis: The set up bioreactor configurations were defined by typical culturing conditions used for fungi organism. Bubble breakage frequency and coalescence rate were simulated using Luo - Colaloglou and Tavlarides models and PBM approaches, respectively. Simulated results from different shear rates due to non-newtonian behaviour are compared by analyzing its influences in bubble size and power input. Findings: A clear relationship between high levels of shear rates and small bubble sizes is found in this work. The later is also associated with the high values of kLa simulated (270 h-1) and compared to levels found at low shear rates (62 h-1). Application/Improvements: Impressed by these findings new design optimizations for non-newtonian bioprocessing applications would be improved using CFD.
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  • Non-Newtonian Behavior Effect on Gas-liquid Mass Transfer using an Anchor Impeller for CSTR Bioreactors:A CFD Approach

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Authors

Lilibeth Nino
Department of Chemical Engineering, Universidad de Antioquia. Carrera 53 N.° 61-30. Medellín, Colombia
Mariana Penuela
Department of Chemical Engineering, Universidad de Antioquia. Carrera 53 N.° 61-30. Medellín, Colombia
Germán Ricardo Gelves
Department of Environment, Universidad Francisco de Paula Santander. Av. Gran Colombia 12E-96, Cúcuta, Colombia

Abstract


Objectives: kLa mass transfer coefficient was predicted using CFD (computational fluid dynamics) for analyzing non-newtonian effects on gas liquid mass transfer in a 10 L bioreactor stirred with an Anchor Impeller. Methods/Statistical Analysis: The set up bioreactor configurations were defined by typical culturing conditions used for fungi organism. Bubble breakage frequency and coalescence rate were simulated using Luo - Colaloglou and Tavlarides models and PBM approaches, respectively. Simulated results from different shear rates due to non-newtonian behaviour are compared by analyzing its influences in bubble size and power input. Findings: A clear relationship between high levels of shear rates and small bubble sizes is found in this work. The later is also associated with the high values of kLa simulated (270 h-1) and compared to levels found at low shear rates (62 h-1). Application/Improvements: Impressed by these findings new design optimizations for non-newtonian bioprocessing applications would be improved using CFD.

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DOI: https://doi.org/10.17485/ijst%2F2018%2Fv11i43%2F129357