Indian Journal of Science and Technology

Open Access Open Access  Restricted Access Subscription Access

Phytochemical Study of Leaves of Muntingia calabura (Muntingiaceae) from Colombia


Affiliations
1 Research Group in Natural Plant Products, Curricular Project of Degree in Chemistry, University Distrital Francisco Jose de Caldas, Carrera 4 # 26 D - 54, Bogotá, Colombia
 

Objectives: Contribute to the phytochemical study of the leaves of the plant species Muntingia calabura (Muntingiaceae) distributed in Colombia. Methods: The leaves of Muntingia calabura, collected in the municipality of Honda, Tolima -Colombia (Geographic coordinates: 5 ° 11 ′28′ ′N, 74 ° 44′ 34 ″ W) were extracted by cold maceration with 96% ethanol; this extract was fractionated by liquid /liquid partition and chromatographic methods. The structural elucidation of the isolated compounds was carried out by CG-MS and NMR techniques (experiments 1H, 13C, COSY, J-MOD and HSQC). Findings: The phytochemical work developed in Muntingia calabura leaves allowed the isolation and identification of a mixture composed of an oxygenated sesquiterpene and a lignan (α-eudesmol and sesamin), hexatriacontane, scopolin and flavonoid 3, 5, 7, 3′, 4′ Pentahidroxiflavona (quercetin) which are identified for the first time for this species.
User

  • LauraVA, Alvarenga AA, Arrigoni MF. Effects of growth regulators, temperature, light, storage and other factors on the Muntingia calabura L. seed germination. Seed Science and Technology. 1994; 22(3):573–9.

  • Zakaria ZA, Kumar GH, Mohd Zaid SNH, Abdul Ghani M, Hassan MH, Mohd Nor Hazalin NA, Khamis MM, Devi RG. Analgesic and antipyretic actions od Muntingia calabura leaves chloroform extract in animal models. Oriental Pharmacy and Experimental Medicine. 2007; 7(1):34–40. https://doi.org/10.3742/OPEM.2007.7.1.034

  • Pisos Termicos en Colombia. Available from: http://www.todacolombia.com/geografia-colombia/pisos-termicos.html

  • Hernandez RM, Carrillo ML, Reyes A. Potencial antioxidante Y antimicrobiano. Revista Academica de Investigación; 2011.

  • Marquez RL, Mendoza D, Parejo MS, Hernández R, Martínez A, Vanegas AM. Evaluacion quimica del extracto total etanolico de las hojas y corteza de Muntingia calabura (Elaeocarpaceae). Scientia et Technical; 2007. p. 455–6.

  • Chen JJ, Lee H, Duh CH, Chen I. Cytotoxic Chalcones and Flavonoids from the Leaves of Muntingia Calabura. Planta Medical. 2005; 71(10):970–3. https://doi.org/10.1055/s-2005-871223 PMid:16254834

  • Bilbao, M. Análisis fitoquímico preliminar. Armenia: Oficina de publicaciones Universidad del Quindío; 1997.

  • Sanabria A. Análisis fitoquímico preliminar. Bogotá: Universidad Nacional de Colombia; 1983.

  • De Vega KA, Aska AR, Guada JA. Utilidad Del Hexatriacontano (C36) Como Marcador De Tránsito Digestivo, Y Efecto Del Procedimiento Analítico Sobre La Utilidad Del Cr-Edta Y Del Ybcl3 Como Marcadores De Flujo. 13 Jornadas Sobre Producción Animal. 2009; 1:313–5.

  • Osuna TL, Tapia ME. Plantas medicinales de la medicina tradicional mexicana para tratar afecciones gastrointestinales. Barcelona: Universitat de Barcelona; 2005. p. 1–173. PMid:16309833

  • Bianco EM, Santos CAM. Substâncias isoladas das folhas de Bauhinia microstachya (Raddi) Macbr. (Caesalpiniaceae). Revista Brasileira de Farmacognosia. 2003; 13(2):93–9. https://doi.org/10.1590/S0102-695X2003000200005

  • García D, Soto H. Alcaloides como una alternativa en la obtención de principios activos. Bioactividad de Productos Naturales. 2001; 6:1–9.

  • Yasunori A, Yoshitaka A, Toshiro K. Stereoselective total synthesis of (-)-α-eudesmol, a P/Q-type calcium channel blocker. Synlett. 2001; 9:1452–4.

  • Kamaliroosta Z, Kamaliroosta L, Elhamirad A. Isolation and Identification of Ginger Essential Oil. Journal of Food Biosciences and Technology. 2013; 73–80.

  • Valtcho D, Astatkie T, Jeliazkova A, Schlegel V. Distillation time alters essential oil yield, composition, and antioxidant activity of male Juniperus scopulorumtres. JournalofOleoSciencie. 2012; 61(10):537–46. https://doi.org/10.5650/jos.61.537

  • Hirose N, Inoue T, Nishihara K, Sugano M, Akimoto K, Shimizu S, Yamada H. Inhibition of cholesterol absorption and synthesis in rats by sesamin. Journal of Lipid Research. 1991; 32(4):629–38. PMid:1856608

  • Alvarez JC. Aislamiento, purificación e identificación de Sesamina a partir de lodos de microfiltrado en la fabricación del aceite virgen de Sesamun indicum L. (ajonjoli). Revista Colombiana de ciencias Quimico-Farmaceuticas. 2007; 36(1).

  • Shaifali MM, Gupta AK, Sushil K. Sesamin a potent antifeedant principle from. Phytotherapy Research; 2001. p. 70–2.

  • Gonzalez CJ. Gicosidos de mussatia sp. y lignanos de Zanthoxylum sp. Química de Plantas Medicinales del Perú; 1988.

  • Ah Jung H, Nurul Islam M, Yong Soo K, Seong Eun J. Extraction and identification of three major aldose reductase inhibitors from Artemisia montana. Food and Chemical Toxicology. 2011; 49:376–84. https://doi.org/10.1016/j.fct.2010.11.012 PMid:21092751

  • Rickard JER. Biochemical changes involved in the postharvest deterioration of cassava ischolar_mains. Tropical Science. 1981; 235–7.

  • Silvan Sen AM. Principios antiinflamatorios de santolina oblongifolia boiss. Madrid: Tesis de la Universidad Complutense de Madrid, Facultad de Farmacia, Departamento de Farmacología; 2002.

  • Gobbo-Neto L, Lopes N. Plantas medicinais: fatores de influência no conteúdo de metabólitos secundários. Química Nova. 2007; 30(2):374–81. https://doi.org/10.1590/S0100-40422007000200026

  • Toso RE, Skliar M. Aislamiento, identificación y cuantificación de compuestos con actividad gastroprotectora presentes en Centaurea solstitialis. Ciencia Veterinaria. 2002; 17–27.


Abstract Views: 197

PDF Views: 0




  • Phytochemical Study of Leaves of Muntingia calabura (Muntingiaceae) from Colombia

Abstract Views: 197  |  PDF Views: 0

Authors

Javier A. Matulevich Pelaez
Research Group in Natural Plant Products, Curricular Project of Degree in Chemistry, University Distrital Francisco Jose de Caldas, Carrera 4 # 26 D - 54, Bogotá, Colombia
William F. Castrillon Cardona
Research Group in Natural Plant Products, Curricular Project of Degree in Chemistry, University Distrital Francisco Jose de Caldas, Carrera 4 # 26 D - 54, Bogotá, Colombia
Karen D. Torres Torres
Research Group in Natural Plant Products, Curricular Project of Degree in Chemistry, University Distrital Francisco Jose de Caldas, Carrera 4 # 26 D - 54, Bogotá, Colombia

Abstract


Objectives: Contribute to the phytochemical study of the leaves of the plant species Muntingia calabura (Muntingiaceae) distributed in Colombia. Methods: The leaves of Muntingia calabura, collected in the municipality of Honda, Tolima -Colombia (Geographic coordinates: 5 ° 11 ′28′ ′N, 74 ° 44′ 34 ″ W) were extracted by cold maceration with 96% ethanol; this extract was fractionated by liquid /liquid partition and chromatographic methods. The structural elucidation of the isolated compounds was carried out by CG-MS and NMR techniques (experiments 1H, 13C, COSY, J-MOD and HSQC). Findings: The phytochemical work developed in Muntingia calabura leaves allowed the isolation and identification of a mixture composed of an oxygenated sesquiterpene and a lignan (α-eudesmol and sesamin), hexatriacontane, scopolin and flavonoid 3, 5, 7, 3′, 4′ Pentahidroxiflavona (quercetin) which are identified for the first time for this species.

References





DOI: https://doi.org/10.17485/ijst%2F2018%2Fv11i31%2F126163