Indian Journal of Science and Technology

Open Access Open Access  Restricted Access Subscription Access

Ocular Findings in Benign Joint Hypermobility Syndrome Patients


Affiliations
1 Rheumatology Unit, Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq
2 Department of Surgery, College of Medicine, University of Baghdad, Baghdad, Iraq
3 Rheumatology Units, Baghdad Teaching Hospital, Baghdad, Iraq
 

Objectives: To evaluate the prevalence and characteristics of ocular findings in a sample of Iraqi patients with (BJHS). Patients and Methods: This cross-sectional study included 100 patients diagnosed with BJHS according to Brieton criteria and another 200 healthy controls matched in age and sex. Demographics were collected, and full ophthalmological examination was done on both groups. Results: Prevalence of refractive errors was 78% of them: myopia was 49%, followed by astigmatism 20%) and hypermetropia 9%. The other identified ocular manifestation was dry eye (15%), while anterior & posterior blepharitis 5% and 4% respectively. Pigment dispersion syndrome was diagnosed in 3% of patients and the cataract was 2% of BJHS patients. All previous findings were statistically significant except cataract not reach to statistically significant level. Conclusions: Ocular findings in BJHS were relatively common. The most common BJHS-related ocular findings were myopia followed by astigmatism and hypermetropia. Dry eye symptoms, anterior and posterior blepharitis, pigment dispersion syndrome and cataract are rare in patients with BJHS.
User

  • Grahame R. Hypermobility and hypermobility syndrome. Keer R, Grahame R. (Editors). Hypermobility Syndrome: Recognition and Management for Physiotherapists. Edinburgh, UK: Butterworth-Heinemann. 2003; p. 1-14. Crossref 1, 2.

  • Grahame R. The revised (Brighton 1998) criteria for the diagnosis of benign joint hypermobility syndrome (BJHS). Journal of Rheumatology. 2000; 27(7):1777-9. PMid:10914867

  • Bravo JF, Wolff C. Clinical study of hereditary disorders of connective tissues in a Chilean population: joint hypermobility syndrome and vascular Ehlers-Danlos syndrome. Arthritis and Rheumatology. 2006; 54(2):515-23. Crossref. PMid:16447226

  • Segev F, H’eon E, Cole WG. Structural abnormalities of the cornea and lid resulting from collagen V mutations. Investigative Ophthalmology & Visual Science. 2006; 47(2):565-73. Crossref. PMid:16431952

  • Whitaker JK, Alexander P, Chau DY. Severe conjunctivochalasis in association with classic type EhlersDanlos syndrome. BMC Ophthalmology. 2012; 12(1):47. Crossref. PMid:22943506 PMCid:PMC3504533

  • Gharbiya M, Moramarco A, Castori M. Ocular features in joint hypermobility syndrome/Ehlers-Danlos syndrome hypermobility type: a clinical and in vivo confocal microscopy study. American Journal of Ophthalmology. 2012; 154(3):593-600. Crossref. PMid:22633352

  • Chikamoto N, Teranishi S, Chikama T. Abnormal retinal blood vessels in Ehlers-Danlos syndrome type VI. Japanese Journal of Ophthalmology. 2007; 51(6):453-5. Crossref. PMid:18158597

  • Puri P, Gupta M, Chan J. Spontaneous perforation of the globe in Ehlers Danlos syndrome. Eye (Lond). 2001; 15(4):553-4. Crossref. PMid:11767041

  • Malfait F, Hakim AJ, De Paepe A. The genetic basis of the joint hypermobility syndromes. Rheumatology. 2006; 45(5):502-07. Crossref. PMid:16418200

  • Chakravarti S, Paul J, Roberts L. Ocular and scleral alterations in gene-targeted lumican-fibromodulin doublenull mice. Investigative Ophthalmology and Visual Science. 2003; 44(6):2422-32. Crossref. PMid:12766039

  • Halfter W, Winzen U, Bishop PN. Regulation of eye size by the retinal basement membrane and vitreous body. Investigative Ophthalmology & Visual Science. 2006; 47(8):3586-94. Crossref. PMid:16877433

  • Wegener A, Holtz FG, Finger R. Characteristics of the anterior eye segment in patients affected by EhlersDanlos-syndrome. Acta Ophthalmologica. 2011; 89(248):1755-3768. Crossref.

  • Lutsevich EE, Plekhova LIU, Borodina NV. Hyperplastic connective tissue syndrome in patients with high myopia. Vestn Oftalmol. 2002; 118(6):33-35. PMid:12506656

  • Gazit Y, Nahir AM, Grahame R. Dysautonomia in the joint hypermobility syndrome. American Journal of Medicine. 2003; 115(1):33-40. Crossref.

  • Schenke-Layland K, Xie J, Angelis E. Increased degradation of extracellular matrix structures of lacrimal glands implicated in the pathogenesis of Sjogren’s syndrome. Matrix Biology. 2008; 27(1):53-66. Crossref. PMid:17689946 PMCid:PMC2394184

  • Jackson WB. Blepharitis: current strategies for diagnosis and management. Canadian journal of ophthalmology. 2008; 43(2):170-79. Crossref. PMid:18347619

  • Bernardes TF, Bonfioli AA. Blepharitis. Seminars in ophthalmology 2010; 25(3):79-83. Crossref. PMid:20590417

  • Veerwal V, Goyal JL, Jain P, Arora R. Pigment dispersion syndrome associated with spontaneous subluxation of crystalline lens. Oman Journal of Ophthalmology. 2017; 10(1):52-53. Crossref. PMid:28298869 PMCid:PMC5338057


Abstract Views: 199

PDF Views: 0




  • Ocular Findings in Benign Joint Hypermobility Syndrome Patients

Abstract Views: 199  |  PDF Views: 0

Authors

Mohammed H. M. Al-Osami
Rheumatology Unit, Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq
Najah K. Mohammad
Department of Surgery, College of Medicine, University of Baghdad, Baghdad, Iraq
Faiq I. Gorial
Rheumatology Unit, Department of Medicine, College of Medicine, University of Baghdad, Baghdad, Iraq
Enas Adnan Majeed
Rheumatology Units, Baghdad Teaching Hospital, Baghdad, Iraq

Abstract


Objectives: To evaluate the prevalence and characteristics of ocular findings in a sample of Iraqi patients with (BJHS). Patients and Methods: This cross-sectional study included 100 patients diagnosed with BJHS according to Brieton criteria and another 200 healthy controls matched in age and sex. Demographics were collected, and full ophthalmological examination was done on both groups. Results: Prevalence of refractive errors was 78% of them: myopia was 49%, followed by astigmatism 20%) and hypermetropia 9%. The other identified ocular manifestation was dry eye (15%), while anterior & posterior blepharitis 5% and 4% respectively. Pigment dispersion syndrome was diagnosed in 3% of patients and the cataract was 2% of BJHS patients. All previous findings were statistically significant except cataract not reach to statistically significant level. Conclusions: Ocular findings in BJHS were relatively common. The most common BJHS-related ocular findings were myopia followed by astigmatism and hypermetropia. Dry eye symptoms, anterior and posterior blepharitis, pigment dispersion syndrome and cataract are rare in patients with BJHS.

References





DOI: https://doi.org/10.17485/ijst%2F2018%2Fv11i26%2F127432