Indian Journal of Science and Technology

Open Access Open Access  Restricted Access Subscription Access

Recent Advances in Biophysical Stimulation of MSC for Bone Regeneration


Affiliations
1 Department of Agroindustrial Engineering, University of Sucre, Cra. 28 #5-267, Puerta Roja, Sincelejo, Colombia
2 Department of Biomedical, Industrial & Human Factors Engineering, Wright State University Dayton, OH. United States of America
3 Department of Civil Engineering, University of Sucre, Cra. 28 #5-267, Puerta Roja, Sincelejo, Colombia
 

Objectives: The purpose of this work was to review the recent advances in biophysical stimulation of MSC for bone regeneration with particular relevance in the tissue engineering field. Methods/Statistical Analysis: The review process had three steps: First, by the use of databases available, the principal findings published related to the different types of biophysical stimulation applied to Mesenchymal Stem cells (MSC) for bone tissue regeneration were compiled. Second, the principal characteristics such as historical relevance, conditions of operation, signaling, and principal results were obtained from each study. And third, considering the above characteristics, a description of each study was realized. Findings: This review highlighted the following findings: a) The capacity of MSC for differentiating to multiple lineages have attracted attention in regenerative medicine applications; b) Biophysical stimulation is an alternative in order to promote the osteodifferentiation of MSC; c) During the process of application of this type of stimulation, the generation of biochemical signals which is related to the changes in the environment of the cell (i.e., cell attachment, proliferation, and differentiation) are generated; and d) Despite a large number of studies published in this area, these do not explain clearly the mechanisms related to the generation of these signaling produced by the biophysical effects (i.e., mechanical, electrical, and electromagnetic). Furthermore, in this review, a compilation of the last five years was done, which emphasize in the aspect historical, conditions of operation, and biochemical signaling generated of each type of biophysical stimulation of MSC for osteodifferentiation. Application/ Improvements: Biophysical stimulation causes multiple effects on the cell environment, producing changes in its morphology, proliferation, and differentiation. The above is important in the biophysical stimulation of MSC for bone regeneration.

Keywords

Biophysical Stimulation, Bone Regeneration, Osteodifferentiation, Stem Cells, Tissue Engineering
User

Abstract Views: 212

PDF Views: 0




  • Recent Advances in Biophysical Stimulation of MSC for Bone Regeneration

Abstract Views: 212  |  PDF Views: 0

Authors

Liliana Polo-Corrales
Department of Agroindustrial Engineering, University of Sucre, Cra. 28 #5-267, Puerta Roja, Sincelejo, Colombia
Jaime Ramirez-Vick
Department of Biomedical, Industrial & Human Factors Engineering, Wright State University Dayton, OH. United States of America
Jhon Jairo Feria-Diaz
Department of Civil Engineering, University of Sucre, Cra. 28 #5-267, Puerta Roja, Sincelejo, Colombia

Abstract


Objectives: The purpose of this work was to review the recent advances in biophysical stimulation of MSC for bone regeneration with particular relevance in the tissue engineering field. Methods/Statistical Analysis: The review process had three steps: First, by the use of databases available, the principal findings published related to the different types of biophysical stimulation applied to Mesenchymal Stem cells (MSC) for bone tissue regeneration were compiled. Second, the principal characteristics such as historical relevance, conditions of operation, signaling, and principal results were obtained from each study. And third, considering the above characteristics, a description of each study was realized. Findings: This review highlighted the following findings: a) The capacity of MSC for differentiating to multiple lineages have attracted attention in regenerative medicine applications; b) Biophysical stimulation is an alternative in order to promote the osteodifferentiation of MSC; c) During the process of application of this type of stimulation, the generation of biochemical signals which is related to the changes in the environment of the cell (i.e., cell attachment, proliferation, and differentiation) are generated; and d) Despite a large number of studies published in this area, these do not explain clearly the mechanisms related to the generation of these signaling produced by the biophysical effects (i.e., mechanical, electrical, and electromagnetic). Furthermore, in this review, a compilation of the last five years was done, which emphasize in the aspect historical, conditions of operation, and biochemical signaling generated of each type of biophysical stimulation of MSC for osteodifferentiation. Application/ Improvements: Biophysical stimulation causes multiple effects on the cell environment, producing changes in its morphology, proliferation, and differentiation. The above is important in the biophysical stimulation of MSC for bone regeneration.

Keywords


Biophysical Stimulation, Bone Regeneration, Osteodifferentiation, Stem Cells, Tissue Engineering



DOI: https://doi.org/10.17485/ijst%2F2018%2Fv11i15%2F172582