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Ashok, Purnima
- Anti-inflammatory and Anti-ulcer Effects of Calotropis gigantea R.Br Flowers in Rodent
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Journal of Natural Remedies, Vol 8, No 2 (2008), Pagination: 183-190Abstract
Objective: To evaluate the chloroform extract of Calotropis gigantea flowers (CCGF) and ethanol extract of Calotropis gigantea flowers (ECGF) for their possible anti-inflammatory (AI) and anti-ulcer (AU) activities. Method: The anti-inflammatory effect of CCGF and ECGF (200mg/kg; p.o.) was investigated in carrageenan induced rat paw edema and cotton pellet induced granuloma model. The AU activity studied in pylorus ligation and aspirin induced gastric ulcers model. The aspirin and ranitidine were used as standards for AI and AU studies respectively. Results: The CCGF and ECGF significantly reduced rat paw edema (p > 0.05 to > 0.01) and dry weight granuloma (p > 0.01). Similarly, both extracts treated group were significantly (p > 0.01) protected from pyloric ligation and aspirin induced gastric ulcers. These effects were statistically significant. Conclusion: The results suggest that the CCGF and ECGF possess significant AI and AU activities. The observed effect may be due to the presence of protease like bioactive constituent.Keywords
Calotropis gigantea Flower, Anti-inflammatory, Anti-ulcer, Aspirin- Comparative Food Intake Inhibitory Activity of Sida cordifolia L. and Withania somnifera L. in Rats
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Journal of Natural Remedies, Vol 7, No 2 (2007), Pagination: 289-293Abstract
Objective: The purpose of the present study was to evaluate food intake inhibitory activity of aqueous extract of Sida cordifolia (AESC) and alcoholic extract of Withania somnifera (AEWS). Both Sida cordifolia Linn. (Malvaceae) and Withania somnifera Linn. (Solanaceae) are widely growing medicinal plants and have been reported to possess number of medicinal properties. Materials and methods: The food intake inhibitory activity of different concentrations of AESC and AEWS (0.5% w/w, 1% w/w and 1.5% w/w) were evaluated by supplementing them with normal feed of rats for seven days, measuring their body weight and food intake daily and compared with the control. Results: There was a significant decrease in food intake (P<0.001) and body weight (P<0.01) with 1 % w/w and 1.5 % w/w of AESC while decrease in food intake and body weight with 0.5 % w/w of AESC was not significant. AEWS showed a significant (P<0.05) decrease in food intake only, but no significant decrease in body weight was observed with AEWS at any dose level. Conclusion: Both extracts were found to have significant food intake inhibitory activity. However when compared to AEWS, AESC was found to be more effective in reducing the food intake and bodyweight.- Hepatoprotective and Antioxidant Potential of Calotropis gigantea in Cyclosporine-An Induced Hepatotoxicity
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Authors
Ajay Kshirsagar
1,
Deepa Ingawale
2,
Purnima Ashok
3,
Vrushali Thorve
2,
Tanmay Dodal
2,
Anurag Dodal
2,
Mahesh Kahane
2,
Bharat Zope
2
Affiliations
1 Pad. Dr. D. Y. Patil Institute of Pharmaceutical sciences and research, Pimpari, Pune-411 018, India, IN
2 AISSMS College of Pharmacy, Near RTO, Kennedy road, Pune-411 001, IN
3 Department of Pharmacology, K.L.E.S's College of Pharmacy, Bangalore-560010, IN
1 Pad. Dr. D. Y. Patil Institute of Pharmaceutical sciences and research, Pimpari, Pune-411 018, India, IN
2 AISSMS College of Pharmacy, Near RTO, Kennedy road, Pune-411 001, IN
3 Department of Pharmacology, K.L.E.S's College of Pharmacy, Bangalore-560010, IN
Source
Research Journal of Pharmacology and Pharmacodynamics, Vol 2, No 5 (2010), Pagination: 343-347Abstract
The ethanolic fraction of Calotropis gigantea flowers (CGFE) was evaluated for its possible hepatoprotective potential in Wistar rats. The CGFE (250mg/kg and 500mg/kg, bw p.o.) showed a remarkable hepatoprotective activity against cyclosporine-A induced hepatotoxicity as judged from the level of serum markers for liver damage. Cyclosporine-A induced a significant rise in serum glutamate oxaloacetate transaminase (SGOT), serum glutamate pyruvate transaminase (SGPT), alkaline phosphatase (ALP) and lipid profile levels. The cotreatment of animals with CGFE (250mg/kg and 500mg/kg, p.o.) significantly decreased the elevated serum marker enzyme and lipid profile levels near to normal. The activity of the CGFE was comparable to the standard drug, silymarin (100mg/kg, p.o.). Further histopathological studies support the above finding.Keywords
Antioxidant, Calotropis gigantea, Cyclosporine-A, Hepatotoxicity.References
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