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Sultana, Mazher
- Studies on Serum Lipids, Lipoproteins and High Sensitive C-reactive Protein in Type 2 Diabetes
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Indian Journal of Science and Technology, Vol 4, No 3 (2011), Pagination: 185-191Abstract
The aim of the study was to determine the association of lipid profile with high sensitivity C-reactive protein (hs-CRP), obese, hypertensive in type 2 diabetes in north Chennai area, Tamil Nadu, India. Nearly 300 blood sample were collected from patients in JPM diagnostic centre, north Chennai, Tamil Nadu and grouped them into diabetic (n=150) and non diabetic (n=150). Behavioral characters were calculated by using the data from the questionnaire like age, sex, height, weight, food habits, obesity, blood pressure (BP), family history, alcohol and smoking habits were correlated for interpretation. The systolic and diastolic blood pressure was measured by using standard mercury sphygmomanometer. Hypertension was diagnosed as per the criteria provided by the WHO (1959&1978). The body weight was calculated by taking weight in kg and height was measured in cms. The body mass index was calculated from the formula BMI = weight in kg/(height in meters)2 Patients were taken as obese if their body mass index was 29.9. All biochemical analyses were done on a semi autoanalyser (RA 50). hs-CRP levels were measured with Elisa reader (Star Fax 325). The lipid concentration level was significantly higher in diabetic patients compared with non diabetic patients, serum total cholesterol mean ± SD 209.57±26.56 (P<0.001), serum triglycerides mean ± SD 184.78±49.10 (P<0.001), serum LDL - cholesterol mean ± SD 165.27±29.43,(P<0.001) and decrease in serum HDL-cholesterol levels mean ± SD 42.30±7.12, (P<0.001), and total cholesterol/HDL ratio, mean ± SD 5.13±1.27 (P<.001), Regression analysis revealed obese to be strongly associated with diabetes observed. BMI mean±SD 26.93-3.10 (P<0.001). hs-CRP values increased with increase of obese mean ± SD 6.71±2.78 (ANOVA P<0.001) and HbA1c mean± SD 8.54±1.07 (ANOVA P<0.001). Lipid concentration is elevated in hypertensive with diabetes serum total cholesterol mean ± SD 211.61±26.21 (P<0.001) and compared with hypertensive with non diabetic subjects. Lipid concentration level increased (Total cholesterol, LDL, TGL&VLDL) and decreased (HDL) in diabetes subjects. Lipoprotein particles significantly higher in diabetic female, compared to diabetic male. hs-CRP, increased in obese diabetes when compared with non obese diabetics, and obese non diabetics. hs-CRP strongly associated in obese with diabetes. Lipid concentration elevated in hypertensive with diabetes. The risk factors such as obesity, smoking, alcohol consumption, hypertension, food habits and family history were found to promote the development of type 2 diabetes.Keywords
Lipid Profile, Lipoprotein C-reactive Protein, Type 2 Diabetes, Obese, Hypertension, HyperlipidaemiaFull Text
- Collagenolytic Activity of Serine Protease of Perionyx excavatus
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PDF Views:108
Authors
Affiliations
1 Dravidian University, Kuppam, AP, IN
2 Dept. of Advanced Zoology and Animal Biotechnology, Presidency College, Chennai, IN
3 Central Leather Research Institute, Adyar, Chennai
1 Dravidian University, Kuppam, AP, IN
2 Dept. of Advanced Zoology and Animal Biotechnology, Presidency College, Chennai, IN
3 Central Leather Research Institute, Adyar, Chennai
Source
Indian Journal of Science and Technology, Vol 4, No 3 (2011), Pagination: 197-200Abstract
A serine collagenolytic protease was purified from the earthworm Perionyx excavates by DEAE-Sephadex A-50 and DEAE-Sephadex A-50 column. The molecular mass of the earthworm serine protease was estimated to be 35 kDa. The purified serine protease was optimally active at pH 6.8-7.8 and 55°C. In vitro studies on collagenolytic activity of this enzyme was also carried out using type I collagen. Hydrolysis of collagen using serine protease was characterized by the collagenolytic activity. The amount of hydroxyproline released (μg/ml) on untanned and tanned leather was monitored. Zymographic analysis was carried out using Collagen as substrate.Keywords
Serine Protease, Collagen, Perionyx excavates, Earthworm, HydroxyprolineFull Text
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- Study of Dust Pollution Caused by Traffic in Thiruvanmiyur Area of Chennai City
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Authors
Affiliations
1 Unit of Environmental Health and Biotechnology, P. G. and Research Department of Zoology, Presidency College, Chennai-600 005, T. N, IN
2 Unit of Environmental Health and Biotechnology, P. G. and Research Department of Zoology, Loyola College, Chennai-600 034, T. N, IN
1 Unit of Environmental Health and Biotechnology, P. G. and Research Department of Zoology, Presidency College, Chennai-600 005, T. N, IN
2 Unit of Environmental Health and Biotechnology, P. G. and Research Department of Zoology, Loyola College, Chennai-600 034, T. N, IN
Source
Nature Environment and Pollution Technology, Vol 7, No 4 (2008), Pagination: 643-646Abstract
The present study deals with the dust pollution caused by vehicles in Thiruvanmiyur area of Chennai city. Four important roads viz., East Coast road, Adayar road, Tidal Park road and Lattice Bridge road of Chennai city were selected. Data revealed that East Coast road was the busiest on which maximum number of vehicles (4221) were passed followed by Adayar road (3668), Lattice Bridge road (2208) and Tidal Park road (2138). On the whole, heavy vehicles were recorded to be in maximum number at all the points on all the roads. Dust fall rate on Tidal Park road (11.14 g/ m2/month) and East Coast road (11.15 g/m2/month) was found to be less, as the condition of the two roads was good and they were used by tourists, software company officers and industrialists etc. The roads were also well maintained by the Corporation of Chennai. The dust fall rate at Adayar road (12.95g/m2/month) and Lattice Bridge road (12.98 g/m2/month) was found to be highest, because these road were thickly populated and in very bad condition.Keywords
Dust Pollution, Dust Fall Rate, Vehicular Traffic, Chennai City.Full Text