Informatics Publishing Limited

B. Sailaja ¹, K. Hemalatha ¹

Affiliations
1 ComputerScience&Engineering, VJIT, Hyderabad, Telangana, IN

Abstract

Education is the most powerful weapon to change the world. The education in engineering begins with theories and progressing to the application of learnt theories. Different methods exist in engineering teaching and learning process. Teaching can be done in many ways - Generally by giving lectures, demonstrations and deliberations. These ways focuses on principle content, emphasizing memory, applications, and understanding the subject. Learning by a student happens in many ways- by seeing and hearing, reflecting and acting, memorizing and visualizing and drawing analogies and building mathematical models. This paper mainly emphasis on innovative methods of teaching and learning process with multidisciplinary approaches to increase the standards of the engineering education and an illustration on engineering education.

Keywords

Multidisciplinary, Innovation, Illustration, Instructors, Engineering Education, Knowledge, Current Techniques, Modern Tools.

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Sushma G. Murthy ¹, K. Hemalatha ¹

Affiliations
1 Department of Social Work, Christ University, Bangalore, IN

Abstract

The study was conducted among the students of 18-19 years studying in the city of Bangalore. 100 samples were collected in a major educational institutional the students of the institution were the respondents. Simple random sampling was used. The study reveals that about 59% of the adolescents are into one or multiple health risk behaviors and it is parental monitoring, a source of parental influence, which is significantly associated with the overall health risk behavior, (p value <0.05). Parental monitoring is an influence proved to be there deciding the presence or absence of health risk behaviors namely consumption of tobacco, alcohol, drugs and practice of unsafe sex

Keywords

Adolescents, Health Risk Behavior, Parental Monitoring.

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S. Sivarajan ¹, K. S. Chandragupta Mauryan ¹, P. Aiswarya ¹, P. Chitra Devi ¹, K. Hemalatha ¹, J. Sujanth Roy ¹

Affiliations
1 Department of EEE, VLB Janakiammal College of Engineering & Technology, Cbe-42, IN

Abstract

In traditional industrial system there is a possibility of faulty products being produced along with the good products. These may sometimes go unnoticed to the packing sector and they mix up with the good ones. This leads to many controversies from the customers. There is a need for automation to detect these faulty products so that only good products are packed and sent out to the world and the status of the company is maintained. The implementation is done by attaching a video camera over the conveyor where the finished products come out. The implementation also has a compression process to compress and store the captured frame to store it for future reference. H.264 algorithm is used here for compression. This uses discrete cosine transform to do the compression.

Keywords

Sobel Operator, H.264 Algorithm.

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D. Sunitha ¹, K. Hemalatha ², M. Nandha Kishora Chary ¹, Rahamat Unissa ¹

Affiliations
1 Department of Pharmaceutical Chemistry, Malla Reddy College of Pharmacy, Maisammaguda, Secunderabad, Telangana, IN
2 Department of Pharmaceutical Chemistry, Acharya and B M Reddy College of Pharmacy, Bangalore, Karnataka, IN

Abstract

The Zika virus is a mosquito-transmitted infection common in Africa and Asia, it did not begin spreading widely in the Western Hemisphere, when an outbreak occurred in Brazil. Few people with less immunity, showed rapidly spreading with infection. Millions of people in tropical regions of the Americas now have been infected. The infection causes no symptoms and leads to no lasting harm. Scientific concern is focused on women who become infected while pregnant and those who develop a temporary form of paralysis after exposure to the virus. The World Health Organization has declared the Zika virus an international public health emergency, that it causes birth defects. As many as four million people could be infected by the end of the year.

Officials at the Centers for Disease Control and Prevention have urged pregnant women against travel to more than thirty countries, mostly in the Caribbean and Latin America, where the outbreak is growing. Some pregnant women who have been to these regions should be tested for the infection.

The infection appears to be linked to the development of unusually small heads and brain damage in newborns - called microcephaly - as well as other neurological defects. In adults, the virus is linked to a form of temporary paralysis. The vast majority of Zika infections are transmitted by mosquitoes, sexually transmitted in only few cases (around dozen).

Recently Bharat Biotech, a Hyderabad-based vaccines and bio-therapeutic manufacturer, developed a vaccine to fight against the dreaded mosquito-borne Zika virus.

This review gives an idea about the recent advances or developments available for treating Zika infection.

Keywords

Zika Virus, Aedes aegypti Mosquito, Birth Defects, Microcephaly, Paralysis.

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D. Sunitha ¹, K. Hemalatha ², M. Sudhakar ¹

Affiliations
1 Malla Reddy College of Pharmacy (Osmania University), Maisammaguda, Hyderabad, Telangana, IN
2 Acharya B. M. Reddy College of Pharmacy, Bangalore, Karnataka, IN

Abstract

Drugs are made to save lives and not cause deaths. Every drug has some side effect if the dose of the drug is correct, then it can be avoided. Some drugs side/ adverse effects can be reduced by another drug. Hence, doctor prescribed medication is safer then self medication. Banned drugs have more adverse/ side effects. Doctors should stop prescribing banned drugs and due to less demand manufacturer will not produce such drugs. As well as the government should make strict laws against the peoples involved in manufacturing and selling of banned drugs. Government should be ordered to dump these cheap drugs in proper manner. And also, India's pharmacovigilance effort has to be scaled up rapidly. People should say stop selling banned drugs.

Keywords

Banned Drugs, Market, Committee, Chemicals, Illegal Drugs.

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K. Hemalatha ¹, K. Girija ¹

Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry-06, IN

Abstract

A series of mannich bases of 1,2-disubstituted benzimidazole derivatives were designed and optimized with Auto Dock 4.2 to investigate the interaction between the target compounds and the amino acid residues of Biotin Carboxylase. Molecular descriptor properties were predicted by Molinspiration software. The free energies of binding and inhibition constants (Ki) of the docked ligands were calculated by the Lamarckian Genetic Algorithm (LGA).Among all the designed compounds, the compound 4e and 6d showed more binding energy-8.85 and -8.56 kcal/mol respectively when compared with the binding energy of the standard drug Mebendazole (-7.24 kcal/mol). Whereas the remaining compounds showed the binding energy in the range between -3.09 to -6.61 kcal/mol. These values suggested that the designed benzimidazole derivatives 4e and 6d are an excellent inhibitor of Biotin Carboxylase.

Keywords

Benzimidazole, Mannich Base, Auto Dock, Biotin Carboxylase, Molinspiration.

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K. Hemalatha ¹, D. Niranjan Raj ¹, M. Fousia Begam ¹, V. K. Sharanya ¹, K. Girija ¹

Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Government of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry-06, IN

Abstract

A series of some novel mannich bases substituted Benzimidazole derivatives were synthesized by condensing Benzimidazole with various aromatic aldehydes and different amino compounds in the presence of ethanol. The purity of the compounds were checked by thin Layer Chromatography and Melting point determination method. The functional group of the compounds were characterized by FT-IR spectroscopy. The Structures of the synthesized compounds were optimized with Auto Dock 4.0.1 to investigate the interaction between the target ligand and the amino acid residues of Biotin Carboxylase to determine the probable model. The title compounds were subjected to preliminary QSAR study using Molinspiration software. All the newly synthesized benzimidazole derivatives were evaluated for their invitro anti-bacterial activity by disc diffusion method by measuring the zone of inhibition and the results were comparable to standard.

Keywords

Benzimidazole, Mannich Base, Auto Dock, Biotin carboxylase, Anti-Bacterial Activity.

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K. Girija ¹, S. Sathiyaraj ¹, V. Rajendiran ², K. Hemalatha ¹

Affiliations
1 Department of Pharmaceutical Chemistry, College of Pharmacy, Mother Theresa Post Graduate and Research Institute of Health Sciences, (A Govt. of Puducherry Institution), Indira Nagar, Gorimedu, Puducherry-605 006, IN
2 Jawaharlal Nehru Technological University, Ananthapur, IN

Abstract

A series of some novel 2, 3-disubstituted quinazolinone derivatives were synthesized by condensing 2-methyl benzoxazine with various amino acids and further reacted with aromatic aldehyde to yield the title compounds. The structures of the synthesized compounds were confirmed by melting point, Thin Layer Chromatography, IR, H1-NMR, Mass and Elemental Analysis. Lipinski's rule of five and Druglikeness properties were evaluated using molinspiration software. Docking study of the synthesized compound were carried out by Auto Dock software using Dihydofolate Reductase Inhibitor as a target enzyme. Synthesized derivatives were screened for their anti-bacterial and anti-fungal activities.

Keywords

Quinazolinone, Amino Acids, Aromatic Aldehyde, Dihydrofolate Reductase, Anti-Bacterial, Anti-Fungal Activity.

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