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Saraswathi, D.
- Visible Spectrophotometric Estimation of Acebrophylline in Bulk and Capsule Formulation
Abstract Views :188 |
PDF Views:74
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Madras Medical College, Chennai-600003, IN
1 Department of Pharmaceutical Chemistry, Madras Medical College, Chennai-600003, IN
Source
Journal of Pharmaceutical Research, Vol 9, No 1 (2010), Pagination: 29-30Abstract
Two simple, sensitive and accurate spectrophotometric methods have been developed for the estimation of Acebrophylline in bulk and in pharmaceutical formulations (Method A&Method B). Method A is based on the formation of orange red colored chromgen with ferric chloride in the presence of 2,22-bipyridyl which obeys beer's law in the concentration range of 10-100 μg/ml exhibiting maximum absorption at 522nm. Method B is based on the diazotization of Acebrophylline with nitrous acid. The diazonium salt formed was then coupled with â-naphthol which shows maximum absorption at 456nm (yellow colored chromogen). It obeys Beer's law in the concentration ranging from 50-300 μg/ml. The methods were extended to capsule formulation and there was no interference from excipients and diluents. These methods have been statistically validated and are found to be precise and accurate.Keywords
Acebrophylline (ACE), Ferric chloride, 2,22-Bipyridyl, Diazotization, α-Naphthol.- Estimation of Acebrophylline in Pharmaceutical Oral Solid Dosage form by RP-HPLC
Abstract Views :168 |
PDF Views:71
Authors
Affiliations
1 Department of Pharmaceutical Chemistry, Madras Medical College, Chennai-600 003, IN
1 Department of Pharmaceutical Chemistry, Madras Medical College, Chennai-600 003, IN
Source
Journal of Pharmaceutical Research, Vol 9, No 3 (2010), Pagination: 115-116Abstract
A simple, specific and accurate reverse phase high performance liquid chromatographic method was developed for the estimation of acebrophylline in capsule dosage form. A phenomenex Gemini C18, 5μm column having 250×4.6mm i.d. in isocratic mode with mobile phase containing diammonium phosphate buffer (pH 4):methanol (60:40) was used. The flow rate was 1mL/minute and effluents were monitored at 273nm. The retention time was found to be 4.54 minutes. The linearity was in the range of 80-120 μg/mL. The proposed method was validated and successfully applied for the estimation of acebrophylline in capsule dosage form.Keywords
Acebrophylline(ACE), RP-HPLC.- An Eminent Tool to Determine Quality of E-Books
Abstract Views :171 |
PDF Views:3
Authors
Affiliations
1 K.S. Rangasamy College of Arts & Science, Tiruchengode-637215, Namakkal, TN, IN
2 Government Arts College, Salem-07, TN, IN
1 K.S. Rangasamy College of Arts & Science, Tiruchengode-637215, Namakkal, TN, IN
2 Government Arts College, Salem-07, TN, IN