Indian Journal of Public Health Research & Development

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Significance of PD-L1 Expression and Tumor Infiltrating Lymphocytes in High Grade Serous Ovarian Cancer:Egyptian Experience


Affiliations
1 Assistant Lecturer, Department of surgical Pathology, National Cancer Institute, Cairo University, Egypt
2 Professor, Author, National Cancer Institute, Surgical Pathology Department, Cairo University, Egypt
3 Lecturer, Author, Biostatistics and Cancer Epidemiology Department National Cancer Institute, Cairo University, Egypt
4 Professor, Medical Oncology Department, National Cancer Institute, Cairo University, Egypt
5 Lecturer, Surgical Oncology Department, National Cancer Institute, Cairo University, Egypt
6 Assistant Professor, Clinical Oncology Department (NEMROCK), Faculty of Medicine, Cairo University, Egypt
7 Lecturer, National Cancer Institute, Surgical Pathology Department, Cairo University, Egypt
     

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We aimed in this study to detect the correlation between PD-L1 and TILs, and their relationship with clinical outcome and survival in Egyptian patients with HGSOC.

Immunohistochemical expression of PD-L1, CD4 and CD8 was investigated in 94 HGSOC Egyptian patients. PD-L1 immunoreactivity was detected in 24% of the cases. The lack of tumor PD-L1 expression proved to be an independent predictive factor for better overall survival (OS) (p=0.01). Moreover, high stromal CD8 + TILs density had a significant impact on better disease-free survival (p=0.007). Patients who showed negative expression of PD-L1 and high intraepithelial CD8+ TILs density lived significantly longer than other patients (p=0.021).


Keywords

PD-L1, HGSOC, TILS, CD4, CD8, Survival, Egypt.
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  • Significance of PD-L1 Expression and Tumor Infiltrating Lymphocytes in High Grade Serous Ovarian Cancer:Egyptian Experience

Abstract Views: 287  |  PDF Views: 0

Authors

Mai Gad
Assistant Lecturer, Department of surgical Pathology, National Cancer Institute, Cairo University, Egypt
Amany Abou-Bakr
Professor, Author, National Cancer Institute, Surgical Pathology Department, Cairo University, Egypt
Rasha Mahmoud Allam
Lecturer, Author, Biostatistics and Cancer Epidemiology Department National Cancer Institute, Cairo University, Egypt
Hanan Ramdan Nassar
Professor, Medical Oncology Department, National Cancer Institute, Cairo University, Egypt
Maher H. Ibraheem
Lecturer, Surgical Oncology Department, National Cancer Institute, Cairo University, Egypt
Soha Talima
Assistant Professor, Clinical Oncology Department (NEMROCK), Faculty of Medicine, Cairo University, Egypt
Ghada Mohamed
Lecturer, National Cancer Institute, Surgical Pathology Department, Cairo University, Egypt

Abstract


We aimed in this study to detect the correlation between PD-L1 and TILs, and their relationship with clinical outcome and survival in Egyptian patients with HGSOC.

Immunohistochemical expression of PD-L1, CD4 and CD8 was investigated in 94 HGSOC Egyptian patients. PD-L1 immunoreactivity was detected in 24% of the cases. The lack of tumor PD-L1 expression proved to be an independent predictive factor for better overall survival (OS) (p=0.01). Moreover, high stromal CD8 + TILs density had a significant impact on better disease-free survival (p=0.007). Patients who showed negative expression of PD-L1 and high intraepithelial CD8+ TILs density lived significantly longer than other patients (p=0.021).


Keywords


PD-L1, HGSOC, TILS, CD4, CD8, Survival, Egypt.



DOI: https://doi.org/10.37506/v11%2Fi1%2F2020%2Fijphrd%2F194098