Indian Journal of Public Health Research & Development

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A Review on Visfatin/Nicotinamide Phosphoribosyltransferase/Pre-B Cell Colony-Enhancing Factor


Affiliations
1 Professor, Department of Biochemistry, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, India
2 MDS Department of Periodontics, Thai Mookambihai Dental College and Hospital, MGR University, Maduravoyal, India
3 Professor, Department of Prosthodontics, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, (BIHER), Pallikaranai, India
4 Associate Professor, Department of Microbiology, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, India
5 Senior Lecturer in Public Health Dentistry, Sree Balaji Dental College & Hospital, Bharath institute of Higher education and Research, Pallikaaranai, Chennai, India
     

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Adipocytokines are mainly adipocyte-derived cytokines regulating metabolism and are key regulators of insulin resistance. Visfatin is a newly discovered adipocyte hormone with a direct relationship type 2 diabetes mellitus. Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is a protein with diverse functions. Although the first discovery of this molecule as a pre-B-cell colony-enhancing factor suggested primarily a cytokine function, its rediscovery as the key enzyme in nicotinamide adenine dinucleotide generation has considerably widened its potential biological activities. Its broad spectrum of effects is being regarded as a potential approach to prevent and treat various pathological conditions.

Keywords

Adipose Tissue, Adipokines, Quinolinc Acid, Insulin Resistance.
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  • A Review on Visfatin/Nicotinamide Phosphoribosyltransferase/Pre-B Cell Colony-Enhancing Factor

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Authors

Jayamathi Govindaraj
Professor, Department of Biochemistry, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, India
Keerthidaa Govindaraj
MDS Department of Periodontics, Thai Mookambihai Dental College and Hospital, MGR University, Maduravoyal, India
S. Raghavendra Jayesh
Professor, Department of Prosthodontics, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, (BIHER), Pallikaranai, India
Padmavathy Kesavaram
Associate Professor, Department of Microbiology, Sree Balaji Dental College & Hospital, Bharath Institute of Higher Education and Research, Pallikaranai, India
U. Vidyarekha
Senior Lecturer in Public Health Dentistry, Sree Balaji Dental College & Hospital, Bharath institute of Higher education and Research, Pallikaaranai, Chennai, India

Abstract


Adipocytokines are mainly adipocyte-derived cytokines regulating metabolism and are key regulators of insulin resistance. Visfatin is a newly discovered adipocyte hormone with a direct relationship type 2 diabetes mellitus. Visfatin/NAMPT (nicotinamide phosphoribosyltransferase) is a protein with diverse functions. Although the first discovery of this molecule as a pre-B-cell colony-enhancing factor suggested primarily a cytokine function, its rediscovery as the key enzyme in nicotinamide adenine dinucleotide generation has considerably widened its potential biological activities. Its broad spectrum of effects is being regarded as a potential approach to prevent and treat various pathological conditions.

Keywords


Adipose Tissue, Adipokines, Quinolinc Acid, Insulin Resistance.