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Ayalogu, E. O.
- Effect of Microgynon, Primolut-N and Postinor on Plasma Total Protein of Wistar Albino Rat (Rattus rattus)
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Authors
Affiliations
1 Department of Biochemistry, Faculty of Science, P.M.B 5323, University of Port Harcourt, Rivers State, NG
2 Department of Biochemistry, Faculty of Science, P.M.B 5323, University of Port Harcourt, Rivers State, IN
1 Department of Biochemistry, Faculty of Science, P.M.B 5323, University of Port Harcourt, Rivers State, NG
2 Department of Biochemistry, Faculty of Science, P.M.B 5323, University of Port Harcourt, Rivers State, IN
Source
Indian Journal of Medicine and Healthcare, Vol 1, No 6 (2012), Pagination: 127-131Abstract
Microgynon a combined pill (0.15mg levonorgestrel and 0.03mg ethinylestradiol), Primolut-N a mini pill (5mg norethister-one) and Postinor a post coital pill (0.75mg levonorgestrel) were analysed for their Invivo effects on wistar albino rat, plasma total protein. Plasma total protein is a measure of the total amount of proteins in the blood. Studies showed that plasma total protein was decreased by the drugs with Microgynon having the highest decrease (0.57 ± 0.19 g/l) (P < 0.05) followed by Primulot (0.95 ± 0.19 g/l) and then Postinor (1.14 ± 0.19 g/l). The random use of the drugs in our society today especially as most women abuse these drugs demands for more biochemical research to elucidate the effects of these drugs not only on the hormones but also, on other biochemical parameters like the plasma total protein. The obtained results indicate that women should use these drugs only after physicians advice.Keywords
Microgynon, Primolut-N, Total ProteinFull Text
References
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- Effects of Oral Contraceptives - Microgynon and Primolut-n on Plasma Creatinine of Wistar Albino Rat
Abstract Views :669 |
PDF Views:323
Authors
Affiliations
1 Department of Biochemistry, Faculty of Science, PMB 5323, University of Port Harcourt, Rivers State, NG
1 Department of Biochemistry, Faculty of Science, PMB 5323, University of Port Harcourt, Rivers State, NG
Source
Indian Journal of Medicine and Healthcare, Vol 1, No 7 (2012), Pagination: 168-171Abstract
Oral contraceptives such as Microgynon a combined pill (0.15mg levonorgestrel and 0.03mg ethinylestradiol) and Primolut -N a mini pill (5mg norethisterone) were investigated for their Invivo effects on wistar albino rat plasma creatinine levels. Test results showed that the drugs raised plasma creatinine levels in a concentration dependent manner but the increase in creatinine levels were not time dependent. The highest increase of 300% was observed for Microgynon at the highest concentration of 3.60μg/100g body wt (354 ± 0.00 μmol/l). The highest increase obtained for Primolut-N was 182.75% (236 ± 29.50μmol/l). The differences in dosage were statistically significant on the effect of the drugs on the plasma creatinine levels at 95.0% confidence level (P<0.05). Creatinine is a protein breakdown product and its level is a reflection of the bodies muscle mass, but unlike urea, creatinine is almost independent of diet. Since the blood level reflects the balance between production and excretion, it varies little from day to day if renal function remains constant. This result makes it imperative that kidney function tests are needed for women before using these drugs.Keywords
Oral Contraceptives, Microgynon, Primolut-n, Plasma CreatinineFull Text
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