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Effect of Microgynon, Primolut-N and Postinor on Plasma Total Protein of Wistar Albino Rat (Rattus rattus)


Affiliations
1 Department of Biochemistry, Faculty of Science, P.M.B 5323, University of Port Harcourt, Rivers State, Nigeria
2 Department of Biochemistry, Faculty of Science, P.M.B 5323, University of Port Harcourt, Rivers State, India
 

Microgynon a combined pill (0.15mg levonorgestrel and 0.03mg ethinylestradiol), Primolut-N a mini pill (5mg norethister-one) and Postinor a post coital pill (0.75mg levonorgestrel) were analysed for their Invivo effects on wistar albino rat, plasma total protein. Plasma total protein is a measure of the total amount of proteins in the blood. Studies showed that plasma total protein was decreased by the drugs with Microgynon having the highest decrease (0.57 ± 0.19 g/l) (P < 0.05) followed by Primulot (0.95 ± 0.19 g/l) and then Postinor (1.14 ± 0.19 g/l). The random use of the drugs in our society today especially as most women abuse these drugs demands for more biochemical research to elucidate the effects of these drugs not only on the hormones but also, on other biochemical parameters like the plasma total protein. The obtained results indicate that women should use these drugs only after physicians advice.

Keywords

Microgynon, Primolut-N, Total Protein
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  • Briggs M (1976) Biochemical effects of oral contraceptives. Adv. Steroid Biochem. Pharmacol. 5, 65 -160

  • CHPE, Division of Reproductive Health (1984) Family planning methods and practice. US Public Health service. Department of Health and Human Services, Atlanta Georgia 30333. USA.

  • Grimes DA, Mishell DR Jr and Speroff L (1993) Contraceptive choices for women with medical problems. Am. J. Obstet. Gynecol. 198, 625-630.

  • Kay CR, Crombie DL, Kuenssberg EV, Pinsent RJFH, Richards B, Smith A, Crowther CH (1974) Oral contraceptives and health. The Royal college of General Practitioners study. Am. J. Obstet. Gynecol. 10,150.

  • Kuhl H and Goethe JW (1990) Pharmacokinetics of oral contraceptives, steroids and drug interaction. Am. J. Obstet. Gynaecol. 163, 2113.

  • Linman WJ (1975) Haematology Macmillian Publishing Co. Inc. London. pp: 74.

  • Mann JL, Doll R, Thorogood M and Vessey MP (1986) Risk factors for myocardial infarction in young women. Br. J. Prev. Soc. Med. 30, 94.

  • Meade TW, Greenberg G and Thompson SG (1980) Progestogens and cardiovascular reactions associated with oral contraceptives and a comparison of the safety of 50- and 30-ug oestrgen preparations. Br. Med. J. 280, 1157.

  • Skouby SO and Jesperson J (1990) Oral contraceptives in the nineties, metabolic aspects, facts and fiction. Am. J. Obstet. Gynecol. 163, 276.

  • Weichselbaum TE (1946) Photometric colorimetric test for total proteins. Am. J. Clin. Path. 16, 40-48.

  • Wilson ES, Curickshank J and McMaster M (1984) A prospective controlled study of the effect on blood pressure of contraceptive preparations containing different types and dosages and progestogen. Br. J. Obstet. Gynaecol. 91, 1254.


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  • Effect of Microgynon, Primolut-N and Postinor on Plasma Total Protein of Wistar Albino Rat (Rattus rattus)

Abstract Views: 540  |  PDF Views: 517

Authors

N. F. Okoye
Department of Biochemistry, Faculty of Science, P.M.B 5323, University of Port Harcourt, Rivers State, Nigeria
A. A. Uwakwe
Department of Biochemistry, Faculty of Science, P.M.B 5323, University of Port Harcourt, Rivers State, India
E. O. Ayalogu
Department of Biochemistry, Faculty of Science, P.M.B 5323, University of Port Harcourt, Rivers State, India

Abstract


Microgynon a combined pill (0.15mg levonorgestrel and 0.03mg ethinylestradiol), Primolut-N a mini pill (5mg norethister-one) and Postinor a post coital pill (0.75mg levonorgestrel) were analysed for their Invivo effects on wistar albino rat, plasma total protein. Plasma total protein is a measure of the total amount of proteins in the blood. Studies showed that plasma total protein was decreased by the drugs with Microgynon having the highest decrease (0.57 ± 0.19 g/l) (P < 0.05) followed by Primulot (0.95 ± 0.19 g/l) and then Postinor (1.14 ± 0.19 g/l). The random use of the drugs in our society today especially as most women abuse these drugs demands for more biochemical research to elucidate the effects of these drugs not only on the hormones but also, on other biochemical parameters like the plasma total protein. The obtained results indicate that women should use these drugs only after physicians advice.

Keywords


Microgynon, Primolut-N, Total Protein

References