Indian Journal of Drugs and Diseases

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The present research work was carried out to study the antioxidant effect of Ocimum sanctum in broilers exposed to high doses of gentamicin, which is common in poultry practice of Tamilnadu. Two hundred and seventy day old broiler chicks of either sex were randomly divided into nine treatment groups of 10 each with three replicates. Different doses of gentamicin (30 mg/kg&50 mg/kg) single intramuscular injection, different inclusion level of Ocimum sanctum crude extract (1%&2 %) in feed and their combinations were tested. The results of the study revealed that gentamicin treatment produced significant increase in the lipid peroxidation level, and significant decrease in the antioxidant enzymes viz. superoxide dismutase and glutathione peroxidase. Ocimum sanctum inclusion showed significant reversal in all the above parameters, which clearly supports its free radical scavenging property when co-administered with high doses of gentamicin.

Keywords

Antioxidant, Broiler Chicks, Ocimum sanctum, Gentamicin
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