Indian Journal of Drugs and Diseases

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Antioxidant Properties of Ocimum sanctum in Broilers Treated with High Doses of Gentamicin


Affiliations
1 Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal, Tamilnadu, Pin code- 637 002, India
 

The present research work was carried out to study the antioxidant effect of Ocimum sanctum in broilers exposed to high doses of gentamicin, which is common in poultry practice of Tamilnadu. Two hundred and seventy day old broiler chicks of either sex were randomly divided into nine treatment groups of 10 each with three replicates. Different doses of gentamicin (30 mg/kg&50 mg/kg) single intramuscular injection, different inclusion level of Ocimum sanctum crude extract (1%&2 %) in feed and their combinations were tested. The results of the study revealed that gentamicin treatment produced significant increase in the lipid peroxidation level, and significant decrease in the antioxidant enzymes viz. superoxide dismutase and glutathione peroxidase. Ocimum sanctum inclusion showed significant reversal in all the above parameters, which clearly supports its free radical scavenging property when co-administered with high doses of gentamicin.

Keywords

Antioxidant, Broiler Chicks, Ocimum sanctum, Gentamicin
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  • Antioxidant Properties of Ocimum sanctum in Broilers Treated with High Doses of Gentamicin

Abstract Views: 539  |  PDF Views: 551

Authors

A. Arivuchelvan
Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal, Tamilnadu, Pin code- 637 002, India
S. Murugesan
Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal, Tamilnadu, Pin code- 637 002, India
P. Mekala
Department of Veterinary Pharmacology and Toxicology, Veterinary College and Research Institute, Namakkal, Tamilnadu, Pin code- 637 002, India

Abstract


The present research work was carried out to study the antioxidant effect of Ocimum sanctum in broilers exposed to high doses of gentamicin, which is common in poultry practice of Tamilnadu. Two hundred and seventy day old broiler chicks of either sex were randomly divided into nine treatment groups of 10 each with three replicates. Different doses of gentamicin (30 mg/kg&50 mg/kg) single intramuscular injection, different inclusion level of Ocimum sanctum crude extract (1%&2 %) in feed and their combinations were tested. The results of the study revealed that gentamicin treatment produced significant increase in the lipid peroxidation level, and significant decrease in the antioxidant enzymes viz. superoxide dismutase and glutathione peroxidase. Ocimum sanctum inclusion showed significant reversal in all the above parameters, which clearly supports its free radical scavenging property when co-administered with high doses of gentamicin.

Keywords


Antioxidant, Broiler Chicks, Ocimum sanctum, Gentamicin

References